ENSG00000105287

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291281 ENSG00000105287 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKD2 protein_coding protein_coding 22.95651 39.4932 12.31565 0.5091182 0.7541513 -1.680305 2.2532455 1.995608 1.9120255 0.2189388 0.2179284 -0.06141213 0.12050417 0.05060000 0.15430000 0.10370000 1.633865e-08 6.988118e-24 FALSE TRUE
ENST00000433867 ENSG00000105287 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKD2 protein_coding protein_coding 22.95651 39.4932 12.31565 0.5091182 0.7541513 -1.680305 2.2559328 4.673631 0.3037650 0.8784487 0.3037650 -3.89987118 0.08369583 0.11820000 0.02673333 -0.09146667 1.284074e-01 6.988118e-24 FALSE TRUE
ENST00000597589 ENSG00000105287 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKD2 protein_coding retained_intron 22.95651 39.4932 12.31565 0.5091182 0.7541513 -1.680305 10.1263887 18.289765 5.2102965 1.1716895 0.4047096 -1.80962147 0.44016667 0.46346667 0.42313333 -0.04033333 7.312208e-01 6.988118e-24 FALSE TRUE
ENST00000602155 ENSG00000105287 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKD2 protein_coding retained_intron 22.95651 39.4932 12.31565 0.5091182 0.7541513 -1.680305 2.7840442 7.602574 0.0000000 1.4837899 0.0000000 -9.57224051 0.07751667 0.19236667 0.00000000 -0.19236667 3.227209e-16 6.988118e-24 FALSE TRUE
MSTRG.17372.4 ENSG00000105287 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKD2 protein_coding   22.95651 39.4932 12.31565 0.5091182 0.7541513 -1.680305 0.2547874 0.000000 0.8789461 0.0000000 0.1010146 6.47402406 0.01894167 0.00000000 0.07140000 0.07140000 6.988118e-24 6.988118e-24 FALSE TRUE
MSTRG.17372.6 ENSG00000105287 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKD2 protein_coding   22.95651 39.4932 12.31565 0.5091182 0.7541513 -1.680305 1.9211087 2.041418 2.5019882 1.0495723 0.1121113 0.29220843 0.10051250 0.05136667 0.20503333 0.15366667 3.694756e-01 6.988118e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105287 E001 3.3161347 0.0048393348 9.325807e-01 9.615416e-01 19 46674275 46674313 39 - 0.575 0.567 -0.035
ENSG00000105287 E002 2.7635737 0.0072656373 3.746525e-01 5.190680e-01 19 46674314 46674315 2 - 0.634 0.493 -0.648
ENSG00000105287 E003 2.7635737 0.0072656373 3.746525e-01 5.190680e-01 19 46674316 46674316 1 - 0.634 0.493 -0.648
ENSG00000105287 E004 5.5207901 0.0032554080 5.341772e-01 6.662827e-01 19 46674317 46674318 2 - 0.814 0.734 -0.320
ENSG00000105287 E005 7.8017023 0.0023405022 5.633128e-01 6.908024e-01 19 46674319 46674319 1 - 0.814 0.898 0.326
ENSG00000105287 E006 13.3185000 0.0013190118 6.764415e-01 7.814204e-01 19 46674320 46674338 19 - 1.038 1.091 0.192
ENSG00000105287 E007 16.2959416 0.0011278217 4.531951e-01 5.939527e-01 19 46674339 46674345 7 - 1.100 1.182 0.296
ENSG00000105287 E008 127.8796359 0.0004546414 3.969859e-05 2.289640e-04 19 46674346 46674507 162 - 1.893 2.065 0.578
ENSG00000105287 E009 284.0193320 0.0035955067 1.698897e-05 1.070802e-04 19 46674508 46674735 228 - 2.235 2.410 0.583
ENSG00000105287 E010 216.7320607 0.0047285146 8.884317e-04 3.573855e-03 19 46675033 46675118 86 - 2.134 2.290 0.523
ENSG00000105287 E011 1.8067887 0.0091009458 5.733366e-01 6.992744e-01 19 46678366 46678395 30 - 0.323 0.436 0.646
ENSG00000105287 E012 257.7172325 0.0033241127 1.305318e-02 3.603582e-02 19 46678396 46678528 133 - 2.250 2.355 0.349
ENSG00000105287 E013 229.2522942 0.0004895187 6.640879e-04 2.767415e-03 19 46678529 46678663 135 - 2.193 2.303 0.367
ENSG00000105287 E014 132.0504489 0.0015785315 4.049793e-02 9.193453e-02 19 46681650 46681682 33 - 1.971 2.065 0.315
ENSG00000105287 E015 162.6453413 0.0008815650 1.997028e-02 5.142114e-02 19 46681683 46681748 66 - 2.061 2.154 0.309
ENSG00000105287 E016 0.2214452 0.0383304772 1.000000e+00   19 46685425 46685521 97 - 0.000 0.077 8.182
ENSG00000105287 E017 0.0000000       19 46685522 46686180 659 -      
ENSG00000105287 E018 259.5241869 0.0001770787 2.756320e-03 9.541305e-03 19 46689537 46689698 162 - 2.265 2.353 0.293
ENSG00000105287 E019 0.0000000       19 46689699 46689709 11 -      
ENSG00000105287 E020 199.1122458 0.0002094350 6.935059e-01 7.945296e-01 19 46690600 46690706 107 - 2.223 2.220 -0.008
ENSG00000105287 E021 140.8593553 0.0002647075 6.299206e-01 7.452154e-01 19 46691735 46691807 73 - 2.075 2.068 -0.026
ENSG00000105287 E022 0.2965864 0.2228955704 7.805694e-01   19 46691808 46691851 44 - 0.000 0.138 8.423
ENSG00000105287 E023 111.5719973 0.0012955734 2.768179e-01 4.162948e-01 19 46691933 46691985 53 - 1.996 1.961 -0.120
ENSG00000105287 E024 260.2991150 0.0007631781 6.158298e-01 7.340046e-01 19 46693875 46694133 259 - 2.338 2.333 -0.014
ENSG00000105287 E025 140.1903408 0.0042597395 9.766760e-01 9.894298e-01 19 46697157 46697234 78 - 2.057 2.070 0.043
ENSG00000105287 E026 32.0062469 0.0006551974 4.909035e-01 6.282226e-01 19 46697235 46697341 107 - 1.393 1.452 0.203
ENSG00000105287 E027 100.0657676 0.0089046995 1.973990e-01 3.229695e-01 19 46697733 46697839 107 - 1.971 1.907 -0.217
ENSG00000105287 E028 53.7105750 0.0039334733 1.132629e-02 3.194478e-02 19 46697840 46697850 11 - 1.762 1.620 -0.482
ENSG00000105287 E029 122.5582340 0.0006611585 2.057198e-02 5.269628e-02 19 46700799 46700952 154 - 2.067 1.990 -0.259
ENSG00000105287 E030 77.8362206 0.0003628853 4.420615e-02 9.877133e-02 19 46701035 46701112 78 - 1.878 1.796 -0.275
ENSG00000105287 E031 111.8239316 0.0014290933 8.842674e-03 2.588897e-02 19 46704169 46704336 168 - 2.042 1.944 -0.328
ENSG00000105287 E032 65.5617299 0.0004157415 2.938720e-04 1.354875e-03 19 46704337 46704391 55 - 1.861 1.697 -0.554
ENSG00000105287 E033 0.0000000       19 46704487 46704494 8 -      
ENSG00000105287 E034 93.7876434 0.0003392309 1.034310e-05 6.852492e-05 19 46704495 46704633 139 - 2.017 1.850 -0.563
ENSG00000105287 E035 47.1938834 0.0005039748 8.912311e-04 3.583519e-03 19 46704634 46704649 16 - 1.732 1.556 -0.598
ENSG00000105287 E036 3.0320343 0.0263292108 2.906550e-01 4.314594e-01 19 46710354 46710906 553 - 0.687 0.517 -0.754
ENSG00000105287 E037 82.7989807 0.0003398155 1.518414e-03 5.695765e-03 19 46710907 46711038 132 - 1.940 1.813 -0.427
ENSG00000105287 E038 69.0871994 0.0003470921 2.025118e-02 5.200868e-02 19 46713863 46714001 139 - 1.841 1.740 -0.340
ENSG00000105287 E039 3.4331087 0.0052921529 8.765236e-02 1.715654e-01 19 46714002 46714324 323 - 0.775 0.519 -1.107
ENSG00000105287 E040 1.5791766 0.0104277834 2.246309e-01 3.559921e-01 19 46714410 46714599 190 - 0.506 0.293 -1.196
ENSG00000105287 E041 34.7051215 0.0039949863 7.367772e-02 1.494163e-01 19 46716131 46716164 34 - 1.560 1.441 -0.408
ENSG00000105287 E042 37.8965324 0.0141570664 2.679399e-01 4.063240e-01 19 46716165 46716220 56 - 1.573 1.489 -0.288
ENSG00000105287 E043 28.1235588 0.0231875237 8.123635e-01 8.809781e-01 19 46716221 46716259 39 - 1.393 1.380 -0.046
ENSG00000105287 E044 60.8480861 0.0093872461 2.267716e-01 3.585325e-01 19 46716260 46716535 276 - 1.762 1.691 -0.240
ENSG00000105287 E045 24.5458417 0.0008143654 6.135717e-08 6.495268e-07 19 46716536 46716814 279 - 1.592 1.214 -1.308
ENSG00000105287 E046 37.6546398 0.0007599753 6.557184e-03 2.007367e-02 19 46716815 46716950 136 - 1.627 1.466 -0.550
ENSG00000105287 E047 28.3562656 0.0008865270 5.648833e-04 2.402466e-03 19 46716951 46717177 227 - 1.560 1.330 -0.793
ENSG00000105287 E048 6.4008832 0.0025561721 3.704861e-12 8.275849e-11 19 46717799 46717976 178 - 1.271 0.436 -3.351
ENSG00000105287 E049 3.0561607 0.0056235550 1.497668e-05 9.561847e-05 19 46718353 46718417 65 - 0.940 0.293 -3.005