ENSG00000105281

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000412532 ENSG00000105281 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC1A5 protein_coding protein_coding 298.1131 417.3377 194.552 14.55122 2.008594 -1.10102 66.67395 147.2958 25.21705 20.76755 2.475584 -2.5457711 0.2073583 0.3538667 0.1298 -0.2240667 0.0004185216 1.615097e-19 FALSE TRUE
ENST00000542575 ENSG00000105281 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC1A5 protein_coding protein_coding 298.1131 417.3377 194.552 14.55122 2.008594 -1.10102 217.03332 252.1922 150.88480 25.19146 3.301217 -0.7410375 0.7405667 0.6032667 0.7754 0.1721333 0.0254924099 1.615097e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105281 E001 21.37419 0.0746814899 9.961493e-06 6.623061e-05 19 46774883 46774884 2 - 0.589 1.423 3.142
ENSG00000105281 E002 121.36460 0.0129433337 4.779164e-01 6.163870e-01 19 46774885 46774923 39 - 1.997 2.055 0.195
ENSG00000105281 E003 178.02908 0.0064356517 1.990434e-01 3.250256e-01 19 46774924 46774925 2 - 2.242 2.189 -0.175
ENSG00000105281 E004 793.70479 0.0051847507 1.610489e-03 5.994741e-03 19 46774926 46774980 55 - 2.749 2.884 0.449
ENSG00000105281 E005 1144.21998 0.0077876921 1.314086e-03 5.024211e-03 19 46774981 46775058 78 - 2.888 3.048 0.531
ENSG00000105281 E006 8630.95527 0.0025402009 2.419043e-05 1.472383e-04 19 46775059 46775747 689 - 3.814 3.911 0.322
ENSG00000105281 E007 3747.48156 0.0008797549 5.342006e-01 6.662938e-01 19 46776975 46777109 135 - 3.508 3.529 0.072
ENSG00000105281 E008 3565.89131 0.0002640299 1.576851e-03 5.883847e-03 19 46777211 46777405 195 - 3.470 3.512 0.138
ENSG00000105281 E009 3484.58356 0.0002494927 1.370263e-03 5.209346e-03 19 46778675 46778908 234 - 3.460 3.502 0.138
ENSG00000105281 E010 1043.89588 0.0001247338 4.056947e-01 5.493460e-01 19 46782383 46782385 3 - 2.968 2.966 -0.006
ENSG00000105281 E011 1482.57090 0.0003354672 5.647943e-01 6.920204e-01 19 46782386 46782435 50 - 3.107 3.125 0.058
ENSG00000105281 E012 2072.02538 0.0007481413 4.592708e-03 1.479870e-02 19 46782436 46782549 114 - 3.289 3.257 -0.106
ENSG00000105281 E013 1511.09265 0.0012376178 4.144457e-09 5.478717e-08 19 46784097 46784144 48 - 3.200 3.098 -0.338
ENSG00000105281 E014 1280.42294 0.0023831711 5.949696e-07 5.187078e-06 19 46784517 46784559 43 - 3.137 3.022 -0.382
ENSG00000105281 E015 72.84512 0.0003770121 3.633069e-19 2.108037e-17 19 46784560 46784594 35 - 2.048 1.680 -1.242
ENSG00000105281 E016 106.40566 0.0002702933 5.085032e-31 9.157263e-29 19 46784595 46784699 105 - 2.227 1.832 -1.326
ENSG00000105281 E017 67.61973 0.0004021664 5.911539e-21 4.240528e-19 19 46784700 46784732 33 - 2.035 1.636 -1.347
ENSG00000105281 E018 81.22206 0.0003108247 1.737352e-16 7.256087e-15 19 46784733 46784949 217 - 2.072 1.751 -1.079
ENSG00000105281 E019 77.08320 0.0073997864 4.402136e-02 9.842811e-02 19 46787239 46787399 161 - 1.919 1.808 -0.374
ENSG00000105281 E020 6285.91015 0.0050145542 1.726521e-03 6.366478e-03 19 46787400 46788594 1195 - 3.804 3.726 -0.258