ENSG00000105186

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306065 ENSG00000105186 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD27 protein_coding protein_coding 15.13089 9.631218 18.40178 0.5966095 0.2478102 0.9333421 11.5031589 7.7674648 14.0169202 0.6612639 0.1247663 0.85082641 0.77012083 0.80513333 0.7619000 -0.04323333 6.559244e-01 3.547559e-17 FALSE TRUE
ENST00000587667 ENSG00000105186 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD27 protein_coding retained_intron 15.13089 9.631218 18.40178 0.5966095 0.2478102 0.9333421 1.2398084 0.7193130 0.7622722 0.2507458 0.1074751 0.08257131 0.08243333 0.07743333 0.0416000 -0.03583333 5.736923e-01 3.547559e-17   FALSE
ENST00000588700 ENSG00000105186 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD27 protein_coding nonsense_mediated_decay 15.13089 9.631218 18.40178 0.5966095 0.2478102 0.9333421 1.4277400 0.0000000 3.2881406 0.0000000 0.4960338 8.36550908 0.07248333 0.00000000 0.1780333 0.17803333 3.547559e-17 3.547559e-17   FALSE
MSTRG.16912.1 ENSG00000105186 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD27 protein_coding   15.13089 9.631218 18.40178 0.5966095 0.2478102 0.9333421 0.4405571 0.9187544 0.0000000 0.2412957 0.0000000 -6.53722524 0.04071250 0.09376667 0.0000000 -0.09376667 8.421222e-14 3.547559e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105186 E001 1.102886 0.0121989077 1.633481e-03 6.068518e-03 19 32596793 32597005 213 - 0.000 0.549 12.663
ENSG00000105186 E002 510.195806 0.0102491445 8.204593e-07 6.940023e-06 19 32597006 32598327 1322 - 2.581 2.832 0.835
ENSG00000105186 E003 81.968530 0.0009914006 1.829068e-02 4.776569e-02 19 32598328 32598378 51 - 1.852 1.985 0.445
ENSG00000105186 E004 99.130051 0.0011675962 4.030644e-02 9.159834e-02 19 32599704 32599776 73 - 1.947 2.062 0.386
ENSG00000105186 E005 91.552929 0.0002888716 5.928179e-02 1.254091e-01 19 32599972 32600050 79 - 1.916 2.023 0.358
ENSG00000105186 E006 6.261566 0.0287711441 2.837160e-01 4.238692e-01 19 32600051 32600286 236 - 0.760 0.939 0.692
ENSG00000105186 E007 88.465275 0.0005425826 3.084220e-01 4.507053e-01 19 32602015 32602126 112 - 1.917 1.994 0.256
ENSG00000105186 E008 85.878559 0.0025350289 2.794205e-01 4.191769e-01 19 32604263 32604424 162 - 1.900 1.985 0.285
ENSG00000105186 E009 74.482942 0.0003640434 9.422363e-01 9.677366e-01 19 32605835 32605954 120 - 1.860 1.894 0.114
ENSG00000105186 E010 98.922704 0.0009742368 6.923215e-01 7.935949e-01 19 32607635 32607832 198 - 1.988 2.010 0.074
ENSG00000105186 E011 72.444770 0.0031851070 4.089544e-01 5.525653e-01 19 32615658 32615780 123 - 1.864 1.859 -0.018
ENSG00000105186 E012 49.282599 0.0174447869 1.901507e-01 3.139656e-01 19 32617589 32617633 45 - 1.727 1.654 -0.248
ENSG00000105186 E013 75.654155 0.0003912703 1.708406e-02 4.512534e-02 19 32619260 32619379 120 - 1.908 1.847 -0.207
ENSG00000105186 E014 54.243257 0.0099653327 7.534934e-01 8.394036e-01 19 32619494 32619553 60 - 1.735 1.748 0.042
ENSG00000105186 E015 91.589860 0.0003347768 3.190731e-01 4.621081e-01 19 32622422 32622619 198 - 1.965 1.965 0.000
ENSG00000105186 E016 66.345437 0.0003998649 4.895175e-01 6.269359e-01 19 32625874 32625966 93 - 1.824 1.831 0.024
ENSG00000105186 E017 59.320325 0.0054117779 1.839391e-01 3.061671e-01 19 32626712 32626806 95 - 1.795 1.757 -0.129
ENSG00000105186 E018 39.971049 0.0007440531 1.357275e-01 2.421225e-01 19 32626807 32626827 21 - 1.629 1.582 -0.162
ENSG00000105186 E019 57.991320 0.0073143239 1.002846e-01 1.909153e-01 19 32628083 32628165 83 - 1.794 1.726 -0.229
ENSG00000105186 E020 86.189105 0.0004192094 4.720150e-03 1.515111e-02 19 32628722 32628849 128 - 1.964 1.889 -0.250
ENSG00000105186 E021 73.325955 0.0003315595 2.796601e-02 6.794671e-02 19 32631402 32631494 93 - 1.889 1.834 -0.186
ENSG00000105186 E022 10.384560 0.0016907475 3.039677e-11 5.849833e-10 19 32637300 32639355 2056 - 0.575 1.337 2.909
ENSG00000105186 E023 95.631319 0.0068953059 2.111581e-01 3.398807e-01 19 32639356 32639488 133 - 1.994 1.957 -0.124
ENSG00000105186 E024 82.866865 0.0041299150 5.565998e-01 6.851870e-01 19 32640307 32640385 79 - 1.916 1.919 0.011
ENSG00000105186 E025 89.381114 0.0042260042 1.789816e-01 2.998650e-01 19 32642024 32642145 122 - 1.965 1.933 -0.105
ENSG00000105186 E026 0.000000       19 32643063 32643122 60 -      
ENSG00000105186 E027 39.502987 0.0005733604 4.017954e-02 9.137160e-02 19 32643123 32643126 4 - 1.637 1.557 -0.272
ENSG00000105186 E028 64.378071 0.0003666276 2.493884e-01 3.852028e-01 19 32643127 32643199 73 - 1.817 1.803 -0.048
ENSG00000105186 E029 0.147249 0.0438904613 7.420468e-01   19 32643200 32643286 87 - 0.097 0.000 -8.855
ENSG00000105186 E030 60.008075 0.0047313726 1.768415e-01 2.971387e-01 19 32643287 32643352 66 - 1.797 1.754 -0.144
ENSG00000105186 E031 61.421602 0.0178344179 1.025112e-01 1.943357e-01 19 32643431 32643484 54 - 1.826 1.732 -0.315
ENSG00000105186 E032 66.770519 0.0030248428 1.693491e-02 4.478756e-02 19 32643572 32643631 60 - 1.858 1.771 -0.296
ENSG00000105186 E033 1.571704 0.4829310178 6.915091e-01 7.929660e-01 19 32643632 32643785 154 - 0.439 0.358 -0.446
ENSG00000105186 E034 71.650085 0.0015739550 7.484894e-03 2.247283e-02 19 32644325 32644396 72 - 1.890 1.803 -0.294
ENSG00000105186 E035 74.686919 0.0009554022 1.376448e-03 5.229609e-03 19 32644397 32644476 80 - 1.915 1.812 -0.348
ENSG00000105186 E036 40.287570 0.0007625767 1.170333e-02 3.282737e-02 19 32644477 32644479 3 - 1.654 1.547 -0.366
ENSG00000105186 E037 70.433725 0.0004313123 1.085709e-03 4.255023e-03 19 32646459 32646603 145 - 1.890 1.785 -0.354
ENSG00000105186 E038 31.188295 0.0006447505 2.267345e-01 3.584921e-01 19 32646604 32646615 12 - 1.520 1.479 -0.138
ENSG00000105186 E039 73.686817 0.0003860883 1.768310e-02 4.645256e-02 19 32649682 32649792 111 - 1.896 1.834 -0.210
ENSG00000105186 E040 66.386002 0.0064258941 4.224327e-02 9.516679e-02 19 32658914 32659045 132 - 1.859 1.779 -0.268
ENSG00000105186 E041 36.884475 0.0044402404 5.963324e-02 1.259978e-01 19 32675071 32675192 122 - 1.614 1.529 -0.290
ENSG00000105186 E042 0.000000       19 32675786 32676597 812 -