ENSG00000105176

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360605 ENSG00000105176 HEK293_OSMI2_2hA HEK293_TMG_2hB URI1 protein_coding protein_coding 45.15623 24.65124 72.56987 1.348646 2.250495 1.557324 6.362648 4.097573 5.669934 0.4208094 0.6294564 0.4675879 0.15057917 0.1691333 0.07813333 -0.09100000 1.051403e-02 1.943492e-23 FALSE TRUE
ENST00000392271 ENSG00000105176 HEK293_OSMI2_2hA HEK293_TMG_2hB URI1 protein_coding protein_coding 45.15623 24.65124 72.56987 1.348646 2.250495 1.557324 8.823940 6.439138 16.465624 0.4320443 0.9631608 1.3531548 0.20623750 0.2616000 0.22663333 -0.03496667 3.891500e-01 1.943492e-23 FALSE TRUE
ENST00000570704 ENSG00000105176 HEK293_OSMI2_2hA HEK293_TMG_2hB URI1 protein_coding processed_transcript 45.15623 24.65124 72.56987 1.348646 2.250495 1.557324 11.446566 3.372743 20.918387 1.7023176 0.6683959 2.6291955 0.21792500 0.1302667 0.28836667 0.15810000 6.294031e-01 1.943492e-23 FALSE FALSE
ENST00000573052 ENSG00000105176 HEK293_OSMI2_2hA HEK293_TMG_2hB URI1 protein_coding protein_coding 45.15623 24.65124 72.56987 1.348646 2.250495 1.557324 1.208498 0.000000 3.744486 0.0000000 0.2677521 8.5524715 0.01932917 0.0000000 0.05150000 0.05150000 1.943492e-23 1.943492e-23   FALSE
ENST00000574110 ENSG00000105176 HEK293_OSMI2_2hA HEK293_TMG_2hB URI1 protein_coding nonsense_mediated_decay 45.15623 24.65124 72.56987 1.348646 2.250495 1.557324 6.824978 6.757682 5.773046 1.0591022 0.5684117 -0.2268321 0.18462500 0.2779333 0.07973333 -0.19820000 2.378902e-04 1.943492e-23 FALSE TRUE
ENST00000575242 ENSG00000105176 HEK293_OSMI2_2hA HEK293_TMG_2hB URI1 protein_coding protein_coding 45.15623 24.65124 72.56987 1.348646 2.250495 1.557324 8.621471 3.747250 15.549800 0.3546997 0.8453250 2.0500743 0.18227500 0.1514333 0.21436667 0.06293333 1.263049e-02 1.943492e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105176 E001 0.0000000       19 29923644 29923656 13 +      
ENSG00000105176 E002 0.0000000       19 29923657 29923690 34 +      
ENSG00000105176 E003 0.0000000       19 29923691 29923711 21 +      
ENSG00000105176 E004 0.0000000       19 29923712 29923733 22 +      
ENSG00000105176 E005 0.0000000       19 29923734 29923754 21 +      
ENSG00000105176 E006 0.0000000       19 29925534 29925897 364 +      
ENSG00000105176 E007 0.0000000       19 29937643 29937997 355 +      
ENSG00000105176 E008 3.2235984 0.0048322684 3.061772e-02 7.317959e-02 19 29942225 29942238 14 + 0.722 0.369 -1.672
ENSG00000105176 E009 16.8620380 0.0014915326 2.609287e-08 2.973900e-07 19 29942239 29942260 22 + 1.380 0.833 -1.986
ENSG00000105176 E010 27.5430326 0.0578901273 1.051503e-03 4.137843e-03 19 29942261 29942268 8 + 1.566 1.127 -1.531
ENSG00000105176 E011 34.3470548 0.0269921585 3.368669e-05 1.978559e-04 19 29942269 29942281 13 + 1.657 1.228 -1.481
ENSG00000105176 E012 44.7509642 0.0104920709 2.594524e-10 4.260421e-09 19 29942282 29942310 29 + 1.782 1.279 -1.726
ENSG00000105176 E013 106.4723930 0.0005567839 4.003439e-09 5.309343e-08 19 29942311 29942664 354 + 2.090 1.881 -0.700
ENSG00000105176 E014 0.1472490 0.0441747809 8.667233e-01   19 29957977 29958072 96 + 0.092 0.000 -10.285
ENSG00000105176 E015 1.1802048 0.0108647759 5.682401e-02 1.211554e-01 19 29971093 29971192 100 + 0.169 0.510 2.234
ENSG00000105176 E016 38.7816398 0.0007107701 9.514587e-01 9.736334e-01 19 29971193 29971227 35 + 1.585 1.605 0.068
ENSG00000105176 E017 0.1451727 0.0432503839 8.670276e-01   19 29980159 29980250 92 + 0.092 0.000 -10.285
ENSG00000105176 E018 0.2214452 0.0401996701 2.712854e-01   19 29980251 29980364 114 + 0.000 0.161 11.841
ENSG00000105176 E019 0.0000000       19 29983233 29983316 84 +      
ENSG00000105176 E020 123.7472591 0.0003498663 3.330722e-01 4.767338e-01 19 29985223 29985301 79 + 2.094 2.078 -0.052
ENSG00000105176 E021 281.0008204 0.0020566110 3.033636e-02 7.262992e-02 19 29986282 29986417 136 + 2.458 2.408 -0.166
ENSG00000105176 E022 0.7447899 0.0550959141 8.565348e-01 9.112789e-01 19 30004295 30004556 262 + 0.233 0.276 0.318
ENSG00000105176 E023 285.1948588 0.0023166860 2.135865e-01 3.427614e-01 19 30005361 30005452 92 + 2.453 2.430 -0.076
ENSG00000105176 E024 244.5366507 0.0033592093 1.728891e-01 2.919450e-01 19 30005651 30005708 58 + 2.391 2.356 -0.114
ENSG00000105176 E025 451.2536740 0.0013017072 1.755584e-04 8.592421e-04 19 30007470 30007638 169 + 2.670 2.598 -0.241
ENSG00000105176 E026 330.9642860 0.0016751584 6.881828e-05 3.743910e-04 19 30009005 30009079 75 + 2.544 2.449 -0.315
ENSG00000105176 E027 582.7190869 0.0008646798 7.069066e-07 6.063905e-06 19 30009080 30009353 274 + 2.786 2.706 -0.266
ENSG00000105176 E028 421.8128294 0.0001423324 2.710881e-02 6.621561e-02 19 30011094 30011236 143 + 2.624 2.601 -0.075
ENSG00000105176 E029 416.9217582 0.0001431549 1.580902e-03 5.896891e-03 19 30012285 30012422 138 + 2.582 2.654 0.241
ENSG00000105176 E030 377.4617220 0.0025435708 1.421823e-03 5.379134e-03 19 30012423 30012531 109 + 2.521 2.634 0.375
ENSG00000105176 E031 28.1323365 0.0007062474 2.554014e-04 1.197709e-03 19 30012532 30012899 368 + 1.531 1.286 -0.848
ENSG00000105176 E032 14.2353894 0.0048578217 2.933647e-01 4.344062e-01 19 30014181 30014222 42 + 1.202 1.116 -0.308
ENSG00000105176 E033 390.9362047 0.0016932235 1.373785e-06 1.107298e-05 19 30014887 30015231 345 + 2.523 2.664 0.470
ENSG00000105176 E034 335.7017714 0.0031219161 8.467958e-16 3.230425e-14 19 30015232 30015535 304 + 2.388 2.665 0.923
ENSG00000105176 E035 246.7294975 0.0076828410 7.348860e-09 9.280226e-08 19 30015536 30016612 1077 + 2.246 2.540 0.981