ENSG00000105173

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262643 ENSG00000105173 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNE1 protein_coding protein_coding 20.95784 26.76895 20.47056 3.202287 0.5351549 -0.386844 6.3099637 6.07534113 8.982428 0.30940996 1.4049844 0.5633725 0.30025000 0.231000000 0.44290000 0.21190000 7.241736e-02 7.264546e-17 FALSE TRUE
ENST00000357943 ENSG00000105173 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNE1 protein_coding protein_coding 20.95784 26.76895 20.47056 3.202287 0.5351549 -0.386844 0.5882653 0.00000000 1.471247 0.00000000 0.3922518 7.2106687 0.03081250 0.000000000 0.07126667 0.07126667 1.663189e-11 7.264546e-17 FALSE TRUE
ENST00000444983 ENSG00000105173 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNE1 protein_coding protein_coding 20.95784 26.76895 20.47056 3.202287 0.5351549 -0.386844 7.9637001 12.96466914 2.965082 2.14776469 0.9386225 -2.1246964 0.38107500 0.478866667 0.14273333 -0.33613333 1.906557e-04 7.264546e-17 FALSE TRUE
ENST00000575243 ENSG00000105173 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNE1 protein_coding protein_coding 20.95784 26.76895 20.47056 3.202287 0.5351549 -0.386844 0.5037274 0.00000000 1.359201 0.00000000 0.7277854 7.0971908 0.02520000 0.000000000 0.06486667 0.06486667 1.589393e-01 7.264546e-17 FALSE FALSE
ENST00000576532 ENSG00000105173 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNE1 protein_coding protein_coding 20.95784 26.76895 20.47056 3.202287 0.5351549 -0.386844 1.2041064 2.78422089 0.000000 0.71305704 0.0000000 -8.1263023 0.05279583 0.100533333 0.00000000 -0.10053333 7.264546e-17 7.264546e-17 FALSE TRUE
MSTRG.16892.1 ENSG00000105173 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNE1 protein_coding   20.95784 26.76895 20.47056 3.202287 0.5351549 -0.386844 0.9659917 0.03947829 2.441053 0.03947829 0.4448981 5.6304622 0.04461250 0.001233333 0.11846667 0.11723333 9.686193e-13 7.264546e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105173 E001 1.185607 0.0108877657 7.861790e-03 2.343323e-02 19 29811907 29811932 26 + 0.566 0.106 -3.277
ENSG00000105173 E002 2.801307 0.0052774132 9.963352e-07 8.268474e-06 19 29811933 29811990 58 + 0.897 0.106 -4.638
ENSG00000105173 E003 5.014650 0.0032042137 3.920348e-12 8.722234e-11 19 29811991 29812003 13 + 1.135 0.106 -5.513
ENSG00000105173 E004 13.434350 0.0126848242 8.888724e-22 6.895750e-20 19 29812004 29812061 58 + 1.530 0.324 -4.894
ENSG00000105173 E005 14.633686 0.0021037186 6.538301e-27 8.380660e-25 19 29812062 29812079 18 + 1.559 0.425 -4.408
ENSG00000105173 E006 38.866705 0.0049842626 2.625539e-09 3.602524e-08 19 29812080 29812152 73 + 1.786 1.399 -1.322
ENSG00000105173 E007 38.201387 0.0126604926 1.362384e-03 5.184494e-03 19 29812532 29812578 47 + 1.722 1.465 -0.876
ENSG00000105173 E008 2.645548 0.0062510240 6.212784e-02 1.302185e-01 19 29812654 29812688 35 + 0.717 0.425 -1.344
ENSG00000105173 E009 57.068047 0.0128474099 4.555182e-03 1.469603e-02 19 29812689 29812724 36 + 1.870 1.657 -0.721
ENSG00000105173 E010 78.672018 0.0075536205 7.042698e-03 2.133452e-02 19 29812725 29812776 52 + 1.982 1.819 -0.547
ENSG00000105173 E011 56.750042 0.0023538577 3.024160e-04 1.389431e-03 19 29812969 29812977 9 + 1.856 1.671 -0.627
ENSG00000105173 E012 111.138315 0.0018173836 1.294941e-06 1.049979e-05 19 29812978 29813037 60 + 2.145 1.959 -0.624
ENSG00000105173 E013 2.317639 0.0066472936 1.506170e-02 4.062926e-02 19 29813038 29813331 294 + 0.717 0.323 -1.929
ENSG00000105173 E014 120.905799 0.0002507821 1.117467e-02 3.158536e-02 19 29817137 29817202 66 + 2.125 2.046 -0.265
ENSG00000105173 E015 149.796757 0.0004820205 5.190910e-02 1.125664e-01 19 29817203 29817282 80 + 2.206 2.150 -0.188
ENSG00000105173 E016 209.340859 0.0026181466 4.639652e-01 6.037168e-01 19 29817406 29817541 136 + 2.329 2.305 -0.080
ENSG00000105173 E017 197.071721 0.0030403918 5.632948e-01 6.907893e-01 19 29820702 29820848 147 + 2.276 2.295 0.064
ENSG00000105173 E018 94.832253 0.0017962194 3.316662e-01 4.753067e-01 19 29821722 29821731 10 + 1.948 1.987 0.132
ENSG00000105173 E019 158.299696 0.0003066475 1.988579e-02 5.124675e-02 19 29821732 29821817 86 + 2.151 2.219 0.228
ENSG00000105173 E020 6.470327 0.0675488442 3.443050e-01 4.883800e-01 19 29821818 29821995 178 + 0.955 0.782 -0.668
ENSG00000105173 E021 176.153499 0.0002157527 2.928217e-03 1.005332e-02 19 29821996 29822130 135 + 2.188 2.270 0.273
ENSG00000105173 E022 184.297449 0.0002929800 1.692255e-05 1.067006e-04 19 29822240 29822351 112 + 2.183 2.300 0.391
ENSG00000105173 E023 252.508416 0.0002499477 2.661656e-08 3.027575e-07 19 29822446 29822603 158 + 2.313 2.442 0.430
ENSG00000105173 E024 421.688275 0.0023843975 1.099853e-09 1.618169e-08 19 29823655 29824312 658 + 2.509 2.669 0.533