ENSG00000105171

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000585603 ENSG00000105171 HEK293_OSMI2_2hA HEK293_TMG_2hB POP4 protein_coding protein_coding 28.22247 23.59075 33.01438 5.232259 1.155125 0.4846988 15.002978 16.6185545 16.153477 3.5627456 0.05397608 -0.0409252 0.54080000 0.70703333 0.49036667 -0.216666667 7.168047e-11 7.168047e-11 FALSE TRUE
ENST00000586173 ENSG00000105171 HEK293_OSMI2_2hA HEK293_TMG_2hB POP4 protein_coding retained_intron 28.22247 23.59075 33.01438 5.232259 1.155125 0.4846988 1.708467 0.9521914 2.117935 0.2132232 0.22024850 1.1450583 0.06215833 0.04400000 0.06440000 0.020400000 4.935335e-01 7.168047e-11   FALSE
ENST00000586823 ENSG00000105171 HEK293_OSMI2_2hA HEK293_TMG_2hB POP4 protein_coding nonsense_mediated_decay 28.22247 23.59075 33.01438 5.232259 1.155125 0.4846988 5.660315 2.0473733 8.119717 1.2649544 0.76842515 1.9824015 0.18100833 0.07196667 0.24510000 0.173133333 3.558272e-01 7.168047e-11 FALSE FALSE
ENST00000588551 ENSG00000105171 HEK293_OSMI2_2hA HEK293_TMG_2hB POP4 protein_coding retained_intron 28.22247 23.59075 33.01438 5.232259 1.155125 0.4846988 2.118165 1.1681562 2.433502 0.2519295 0.27541295 1.0524198 0.07910833 0.05400000 0.07343333 0.019433333 5.785605e-01 7.168047e-11 FALSE FALSE
ENST00000592749 ENSG00000105171 HEK293_OSMI2_2hA HEK293_TMG_2hB POP4 protein_coding retained_intron 28.22247 23.59075 33.01438 5.232259 1.155125 0.4846988 2.068784 1.3907023 2.125076 0.5530050 0.38026923 0.6081368 0.07735833 0.05930000 0.06473333 0.005433333 9.030296e-01 7.168047e-11   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105171 E001 19.1599372 0.0011126720 9.194422e-03 0.0267714208 19 29606283 29606293 11 + 1.392 1.210 -0.637
ENSG00000105171 E002 27.9490719 0.0007715584 1.925223e-01 0.3169258495 19 29606294 29606297 4 + 1.497 1.434 -0.217
ENSG00000105171 E003 54.9590482 0.0013014722 1.571464e-01 0.2713031927 19 29606298 29606302 5 + 1.777 1.726 -0.172
ENSG00000105171 E004 60.2453082 0.0027873542 2.053791e-01 0.3328923125 19 29606303 29606303 1 + 1.815 1.765 -0.170
ENSG00000105171 E005 132.4612962 0.0036070839 1.677453e-01 0.2852595640 19 29606304 29606320 17 + 2.153 2.105 -0.161
ENSG00000105171 E006 138.7886298 0.0018056483 1.218770e-01 0.2225962030 19 29606321 29606325 5 + 2.171 2.130 -0.135
ENSG00000105171 E007 0.0000000       19 29606326 29606371 46 +      
ENSG00000105171 E008 0.4396707 0.0261275512 8.758809e-02 0.1714786235 19 29606372 29606489 118 + 0.292 0.000 -10.403
ENSG00000105171 E009 192.2785686 0.0012340711 2.423254e-01 0.3769176172 19 29608657 29608709 53 + 2.301 2.282 -0.062
ENSG00000105171 E010 7.5281235 0.0269720737 8.506293e-03 0.0250538977 19 29608710 29608744 35 + 1.087 0.748 -1.287
ENSG00000105171 E011 20.4104923 0.0042433574 1.658580e-03 0.0061494642 19 29608745 29609242 498 + 1.440 1.201 -0.833
ENSG00000105171 E012 4.4562320 0.0321297355 1.173596e-03 0.0045518314 19 29610240 29610251 12 + 0.939 0.424 -2.217
ENSG00000105171 E013 5.1924891 0.0072790648 5.280667e-04 0.0022646440 19 29610252 29610284 33 + 0.984 0.520 -1.900
ENSG00000105171 E014 6.9385197 0.0023540712 3.170854e-02 0.0752805564 19 29610320 29610408 89 + 1.012 0.776 -0.902
ENSG00000105171 E015 178.5860132 0.0001968541 2.049005e-01 0.3322757679 19 29610409 29610457 49 + 2.268 2.257 -0.035
ENSG00000105171 E016 318.2692539 0.0012721217 5.225388e-01 0.6563374347 19 29610458 29610632 175 + 2.509 2.511 0.007
ENSG00000105171 E017 19.7059976 0.0278624513 4.909613e-02 0.1075419942 19 29610633 29611122 490 + 1.420 1.201 -0.765
ENSG00000105171 E018 17.3251308 0.0410762292 4.856985e-01 0.6235437132 19 29611514 29611861 348 + 1.299 1.231 -0.237
ENSG00000105171 E019 142.2067692 0.0006012564 1.168922e-01 0.2155365609 19 29611862 29611867 6 + 2.179 2.155 -0.082
ENSG00000105171 E020 248.7376613 0.0002359191 2.672202e-01 0.4055213198 19 29611868 29611939 72 + 2.407 2.405 -0.008
ENSG00000105171 E021 245.6093980 0.0004237265 3.903054e-01 0.5342913328 19 29612117 29612178 62 + 2.399 2.402 0.009
ENSG00000105171 E022 0.8104664 0.0191034507 6.713981e-01 0.7776332202 19 29613203 29613239 37 + 0.215 0.299 0.633
ENSG00000105171 E023 1.3714610 0.0116907107 4.968898e-01 0.6334672067 19 29613825 29613870 46 + 0.292 0.424 0.787
ENSG00000105171 E024 285.2786098 0.0006926946 6.271701e-02 0.1312298412 19 29613871 29613972 102 + 2.430 2.496 0.219
ENSG00000105171 E025 801.9480799 0.0025391687 2.049332e-05 0.0001268177 19 29615244 29617237 1994 + 2.847 2.953 0.352