ENSG00000105135

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263383 ENSG00000105135 HEK293_OSMI2_2hA HEK293_TMG_2hB ILVBL protein_coding protein_coding 56.98429 85.59355 32.96774 4.55423 0.7237522 -1.376178 41.629699 68.311147 20.186558 3.28265764 0.3076616 -1.7582228 0.70575417 0.79856667 0.61280000 -0.1857667 1.285758e-12 1.285758e-12 FALSE TRUE
ENST00000525880 ENSG00000105135 HEK293_OSMI2_2hA HEK293_TMG_2hB ILVBL protein_coding retained_intron 56.98429 85.59355 32.96774 4.55423 0.7237522 -1.376178 3.768618 3.622735 3.272154 0.03408759 0.4989663 -0.1464133 0.07324167 0.04256667 0.09866667 0.0561000 2.002338e-04 1.285758e-12 FALSE TRUE
MSTRG.16607.1 ENSG00000105135 HEK293_OSMI2_2hA HEK293_TMG_2hB ILVBL protein_coding   56.98429 85.59355 32.96774 4.55423 0.7237522 -1.376178 5.152602 6.992166 3.157816 0.63296490 0.3129220 -1.1443128 0.09478750 0.08170000 0.09630000 0.0146000 6.919104e-01 1.285758e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105135 E001 8.063895 0.0027745206 4.684409e-01 6.078542e-01 19 15114984 15114986 3 - 0.938 0.851 -0.330
ENSG00000105135 E002 100.772178 0.0234836036 9.406153e-02 1.814779e-01 19 15114987 15115015 29 - 1.783 1.941 0.532
ENSG00000105135 E003 522.176758 0.0082141646 1.236546e-02 3.441203e-02 19 15115016 15115271 256 - 2.516 2.646 0.433
ENSG00000105135 E004 643.562703 0.0009648189 5.813973e-05 3.223129e-04 19 15115272 15115430 159 - 2.631 2.731 0.332
ENSG00000105135 E005 29.110628 0.0047433648 3.419469e-03 1.149513e-02 19 15115431 15115557 127 - 1.547 1.329 -0.752
ENSG00000105135 E006 14.680488 0.0012349821 4.703370e-02 1.038846e-01 19 15115558 15115565 8 - 1.244 1.057 -0.666
ENSG00000105135 E007 573.070465 0.0001109790 3.756339e-02 8.651686e-02 19 15115566 15115671 106 - 2.623 2.668 0.151
ENSG00000105135 E008 24.575863 0.0007675144 1.280554e-08 1.547618e-07 19 15115672 15115849 178 - 1.602 1.196 -1.404
ENSG00000105135 E009 291.430658 0.0001975831 6.573196e-01 7.666869e-01 19 15115850 15115859 10 - 2.369 2.365 -0.014
ENSG00000105135 E010 323.009577 0.0001764142 7.725500e-01 8.531863e-01 19 15115860 15115884 25 - 2.410 2.410 0.000
ENSG00000105135 E011 370.065016 0.0023526713 6.521858e-01 7.629137e-01 19 15115885 15115921 37 - 2.454 2.477 0.077
ENSG00000105135 E012 18.202740 0.0010411070 6.312887e-08 6.665315e-07 19 15115922 15116000 79 - 1.501 1.064 -1.535
ENSG00000105135 E013 389.432623 0.0007664925 8.787262e-01 9.261001e-01 19 15116001 15116071 71 - 2.484 2.496 0.040
ENSG00000105135 E014 24.917658 0.0118368195 2.450586e-03 8.615683e-03 19 15116072 15116151 80 - 1.517 1.253 -0.913
ENSG00000105135 E015 488.865766 0.0001148833 1.017731e-02 2.920137e-02 19 15116152 15116282 131 - 2.542 2.601 0.196
ENSG00000105135 E016 351.853436 0.0007898753 2.121139e-01 3.410250e-01 19 15116283 15116321 39 - 2.416 2.458 0.138
ENSG00000105135 E017 445.607363 0.0023946869 1.421162e-01 2.509132e-01 19 15116408 15116461 54 - 2.506 2.563 0.189
ENSG00000105135 E018 475.683235 0.0002443021 2.389123e-01 3.728547e-01 19 15116462 15116522 61 - 2.553 2.585 0.107
ENSG00000105135 E019 58.322024 0.0009058023 2.089420e-17 9.778518e-16 19 15116523 15117880 1358 - 1.966 1.552 -1.400
ENSG00000105135 E020 669.389824 0.0001462642 1.793040e-02 4.698611e-02 19 15117881 15118015 135 - 2.751 2.719 -0.107
ENSG00000105135 E021 492.274050 0.0002078888 2.556348e-03 8.931330e-03 19 15119166 15119245 80 - 2.633 2.581 -0.172
ENSG00000105135 E022 373.262587 0.0001959986 1.692205e-02 4.476105e-02 19 15119246 15119302 57 - 2.509 2.463 -0.153
ENSG00000105135 E023 404.267552 0.0001658717 5.436767e-01 6.742467e-01 19 15119418 15119515 98 - 2.513 2.507 -0.020
ENSG00000105135 E024 1.329542 0.0109859832 4.564468e-01 5.968587e-01 19 15119980 15119981 2 - 0.202 0.353 1.085
ENSG00000105135 E025 251.049335 0.0001713071 5.965078e-02 1.260250e-01 19 15119982 15120010 29 - 2.253 2.313 0.200
ENSG00000105135 E026 317.313105 0.0001570673 1.580054e-01 2.724783e-01 19 15120011 15120081 71 - 2.368 2.410 0.141
ENSG00000105135 E027 394.174457 0.0001799544 3.394749e-01 4.834000e-01 19 15122693 15122804 112 - 2.473 2.502 0.095
ENSG00000105135 E028 11.484225 0.0142318757 1.026434e-05 6.805309e-05 19 15122805 15122891 87 - 1.336 0.853 -1.753
ENSG00000105135 E029 376.665910 0.0007542717 7.287400e-01 8.211355e-01 19 15122892 15122997 106 - 2.477 2.476 -0.001
ENSG00000105135 E030 255.023309 0.0003471436 8.624577e-01 9.153144e-01 19 15122998 15123030 33 - 2.305 2.307 0.008
ENSG00000105135 E031 356.013316 0.0002214109 1.908431e-01 3.148044e-01 19 15123116 15123243 128 - 2.470 2.447 -0.077
ENSG00000105135 E032 437.992477 0.0001699852 5.232527e-01 6.569685e-01 19 15123375 15123576 202 - 2.547 2.541 -0.020
ENSG00000105135 E033 19.647307 0.0009897883 4.427834e-13 1.150830e-11 19 15123577 15124034 458 - 1.595 1.036 -1.958
ENSG00000105135 E034 11.259211 0.0022908758 3.894486e-12 8.671822e-11 19 15124563 15124924 362 - 1.431 0.753 -2.476
ENSG00000105135 E035 321.723823 0.0018771012 2.534998e-01 3.900295e-01 19 15124925 15125069 145 - 2.431 2.404 -0.088
ENSG00000105135 E036 18.641829 0.0161094496 3.070861e-07 2.835114e-06 19 15125070 15125362 293 - 1.532 1.035 -1.747
ENSG00000105135 E037 64.911607 0.0008149096 1.191379e-04 6.099429e-04 19 15125380 15125655 276 - 1.860 1.674 -0.629
ENSG00000105135 E038 142.694938 0.0029613094 9.481843e-01 9.714755e-01 19 15125656 15125661 6 - 2.047 2.059 0.041
ENSG00000105135 E039 171.503170 0.0057998198 6.531132e-01 7.636778e-01 19 15125662 15125786 125 - 2.109 2.144 0.117