ENSG00000105072

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221671 ENSG00000105072 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf44 protein_coding protein_coding 8.019342 11.25167 5.147521 0.3068701 0.2948525 -1.126671 4.1922154 4.9802660 2.95567196 0.7120590 0.05949927 -0.7507577 0.53602083 0.44306667 0.57790000 0.1348333 3.535786e-01 4.963049e-09 FALSE TRUE
ENST00000594035 ENSG00000105072 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf44 protein_coding protein_coding 8.019342 11.25167 5.147521 0.3068701 0.2948525 -1.126671 0.9695969 0.9261115 1.58318864 0.1412979 0.03694857 0.7671649 0.13530417 0.08270000 0.30886667 0.2261667 4.963049e-09 4.963049e-09 FALSE TRUE
ENST00000601109 ENSG00000105072 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf44 protein_coding nonsense_mediated_decay 8.019342 11.25167 5.147521 0.3068701 0.2948525 -1.126671 0.9200970 3.1530973 0.08703774 0.9582888 0.08703774 -5.0266482 0.08688333 0.27940000 0.01573333 -0.2636667 1.266792e-02 4.963049e-09 FALSE TRUE
ENST00000601288 ENSG00000105072 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf44 protein_coding protein_coding 8.019342 11.25167 5.147521 0.3068701 0.2948525 -1.126671 1.0640884 1.1637178 0.00000000 0.5853403 0.00000000 -6.8749418 0.11020833 0.10323333 0.00000000 -0.1032333 2.672952e-01 4.963049e-09   FALSE
MSTRG.16643.5 ENSG00000105072 HEK293_OSMI2_2hA HEK293_TMG_2hB C19orf44 protein_coding   8.019342 11.25167 5.147521 0.3068701 0.2948525 -1.126671 0.5779213 0.6496686 0.24929327 0.6496686 0.24929327 -1.3471568 0.09015417 0.05853333 0.04503333 -0.0135000 9.732094e-01 4.963049e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105072 E001 0.0000000       19 16496394 16496405 12 +      
ENSG00000105072 E002 0.0000000       19 16496406 16496406 1 +      
ENSG00000105072 E003 7.5031981 0.0163498439 3.791810e-03 1.255895e-02 19 16496407 16496438 32 + 1.112 0.750 -1.369
ENSG00000105072 E004 10.8902868 0.0193212435 4.881452e-04 2.114790e-03 19 16496439 16496455 17 + 1.277 0.874 -1.466
ENSG00000105072 E005 11.7718289 0.0200176942 7.184554e-04 2.965019e-03 19 16496456 16496462 7 + 1.297 0.913 -1.389
ENSG00000105072 E006 11.9170016 0.0169306334 3.491137e-04 1.576679e-03 19 16496463 16496465 3 + 1.307 0.913 -1.425
ENSG00000105072 E007 0.0000000       19 16496466 16496692 227 +      
ENSG00000105072 E008 0.1482932 0.0412911540 1.000000e+00   19 16499474 16499620 147 + 0.000 0.090 7.912
ENSG00000105072 E009 90.1630711 0.0008447018 4.736719e-10 7.445094e-09 19 16500792 16501299 508 + 2.069 1.838 -0.777
ENSG00000105072 E010 51.4434352 0.0245382901 1.170545e-01 2.157455e-01 19 16501300 16501426 127 + 1.776 1.632 -0.489
ENSG00000105072 E011 50.0350401 0.0006610694 3.563094e-01 5.006879e-01 19 16501427 16501551 125 + 1.696 1.651 -0.152
ENSG00000105072 E012 73.2807429 0.0005635147 4.571975e-02 1.015198e-01 19 16503065 16503380 316 + 1.883 1.801 -0.275
ENSG00000105072 E013 30.9547463 0.0233519892 5.173223e-01 6.517298e-01 19 16506701 16506774 74 + 1.503 1.445 -0.198
ENSG00000105072 E014 111.9259435 0.0063357001 6.044202e-01 7.249850e-01 19 16509499 16509988 490 + 2.024 2.005 -0.065
ENSG00000105072 E015 23.3760591 0.0008277141 1.350246e-02 3.708162e-02 19 16513014 16513032 19 + 1.196 1.398 0.706
ENSG00000105072 E016 29.4978637 0.0006832382 1.791142e-01 3.000340e-01 19 16513033 16513068 36 + 1.371 1.468 0.333
ENSG00000105072 E017 27.7026175 0.0009060080 4.851722e-01 6.231004e-01 19 16513069 16513109 41 + 1.380 1.432 0.182
ENSG00000105072 E018 38.9778543 0.0005576403 1.146725e-02 3.227508e-02 19 16514497 16514549 53 + 1.442 1.602 0.548
ENSG00000105072 E019 49.0051746 0.0004968806 1.055305e-02 3.009822e-02 19 16514550 16514663 114 + 1.550 1.694 0.491
ENSG00000105072 E020 58.6279633 0.0027851124 5.962761e-02 1.259901e-01 19 16517230 16517341 112 + 1.658 1.763 0.355
ENSG00000105072 E021 46.0067491 0.0006110894 4.271770e-01 5.700076e-01 19 16518002 16518619 618 + 1.663 1.623 -0.134
ENSG00000105072 E022 223.0568701 0.0028454742 1.847155e-10 3.112773e-09 19 16520094 16521352 1259 + 2.150 2.361 0.707