ENSG00000105053

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316763 ENSG00000105053 HEK293_OSMI2_2hA HEK293_TMG_2hB VRK3 protein_coding protein_coding 41.75639 67.35802 25.0444 2.336706 0.179373 -1.427 3.664083 7.044547 2.5509002 0.6833672 0.62853961 -1.4619025 0.08113750 0.10556667 0.10170000 -0.003866667 0.9490652450 0.0002563908 FALSE  
ENST00000424804 ENSG00000105053 HEK293_OSMI2_2hA HEK293_TMG_2hB VRK3 protein_coding processed_transcript 41.75639 67.35802 25.0444 2.336706 0.179373 -1.427 3.901617 4.059815 3.8719428 0.7593643 0.26611429 -0.0681842 0.10368333 0.05963333 0.15470000 0.095066667 0.0002563908 0.0002563908 FALSE  
ENST00000593912 ENSG00000105053 HEK293_OSMI2_2hA HEK293_TMG_2hB VRK3 protein_coding protein_coding 41.75639 67.35802 25.0444 2.336706 0.179373 -1.427 2.366608 4.519034 0.6954784 0.1080224 0.12116295 -2.6825295 0.05420833 0.06730000 0.02773333 -0.039566667 0.0003972097 0.0002563908 FALSE  
ENST00000593919 ENSG00000105053 HEK293_OSMI2_2hA HEK293_TMG_2hB VRK3 protein_coding protein_coding 41.75639 67.35802 25.0444 2.336706 0.179373 -1.427 2.298171 3.940085 1.0429431 0.4139583 0.16600687 -1.9074562 0.05334583 0.05823333 0.04160000 -0.016633333 0.3473203451 0.0002563908 FALSE  
ENST00000594092 ENSG00000105053 HEK293_OSMI2_2hA HEK293_TMG_2hB VRK3 protein_coding protein_coding 41.75639 67.35802 25.0444 2.336706 0.179373 -1.427 7.862703 12.599287 4.6194592 0.9149343 0.56319835 -1.4455712 0.18662083 0.18696667 0.18473333 -0.002233333 0.9812364265 0.0002563908 FALSE  
ENST00000600284 ENSG00000105053 HEK293_OSMI2_2hA HEK293_TMG_2hB VRK3 protein_coding processed_transcript 41.75639 67.35802 25.0444 2.336706 0.179373 -1.427 3.769081 6.560803 1.7654534 0.2123969 0.09810445 -1.8878822 0.08555833 0.09743333 0.07046667 -0.026966667 0.0431731930 0.0002563908 FALSE  
MSTRG.17537.2 ENSG00000105053 HEK293_OSMI2_2hA HEK293_TMG_2hB VRK3 protein_coding   41.75639 67.35802 25.0444 2.336706 0.179373 -1.427 14.982697 25.833819 8.7657245 1.1370302 0.43374905 -1.5582291 0.35530417 0.38326667 0.35006667 -0.033200000 0.5207826857 0.0002563908 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105053 E001 2.6453677 0.0111051780 5.780062e-01 7.031615e-01 19 49976468 49976487 20 - 0.432 0.533 0.501
ENSG00000105053 E002 2.7968831 0.0121679106 9.147132e-01 9.500062e-01 19 49976488 49976491 4 - 0.515 0.533 0.086
ENSG00000105053 E003 277.5685051 0.0016144363 7.331405e-05 3.961305e-04 19 49976492 49976759 268 - 2.256 2.383 0.426
ENSG00000105053 E004 148.6962164 0.0002786873 2.278878e-04 1.082809e-03 19 49976760 49976784 25 - 1.982 2.115 0.444
ENSG00000105053 E005 6.3201869 0.0409545556 7.877858e-03 2.347263e-02 19 49978569 49978712 144 - 1.073 0.673 -1.546
ENSG00000105053 E006 3.3892919 0.0047577029 3.960646e-04 1.759320e-03 19 49978713 49978759 47 - 0.924 0.396 -2.311
ENSG00000105053 E007 6.0575608 0.0071244985 7.183110e-02 1.463902e-01 19 49978760 49978877 118 - 0.952 0.708 -0.957
ENSG00000105053 E008 5.7244297 0.0091276187 1.933339e-02 5.005539e-02 19 49978878 49979082 205 - 0.979 0.658 -1.267
ENSG00000105053 E009 321.4194120 0.0017185080 7.819815e-02 1.565674e-01 19 49979083 49979242 160 - 2.380 2.432 0.175
ENSG00000105053 E010 198.9617572 0.0038720701 5.542200e-01 6.832341e-01 19 49980955 49981013 59 - 2.197 2.219 0.076
ENSG00000105053 E011 1.9207152 0.0421068544 2.216378e-01 3.523570e-01 19 49981014 49981184 171 - 0.585 0.361 -1.134
ENSG00000105053 E012 1.5917749 0.0096088636 2.942014e-01 4.353010e-01 19 49981654 49981699 46 - 0.515 0.325 -1.028
ENSG00000105053 E013 110.6368260 0.0055986942 2.674539e-01 4.057719e-01 19 49981700 49982188 489 - 1.916 1.975 0.199
ENSG00000105053 E014 29.6527100 0.0006625626 3.564900e-05 2.079950e-04 19 49986299 49986544 246 - 1.093 1.456 1.277
ENSG00000105053 E015 44.0838031 0.0005145074 7.640704e-03 2.287502e-02 19 49986742 49986933 192 - 1.425 1.601 0.604
ENSG00000105053 E016 28.2772850 0.0006963396 7.696625e-01 8.512579e-01 19 49987701 49988290 590 - 1.365 1.385 0.070
ENSG00000105053 E017 11.6721349 0.0138560418 4.936578e-01 6.306526e-01 19 49988291 49988371 81 - 0.952 1.037 0.315
ENSG00000105053 E018 357.9598379 0.0001747666 6.305246e-02 1.317920e-01 19 49988372 49988492 121 - 2.437 2.477 0.132
ENSG00000105053 E019 197.7444886 0.0013060126 2.893790e-01 4.300611e-01 19 49989639 49989665 27 - 2.186 2.221 0.116
ENSG00000105053 E020 217.6430704 0.0001994399 2.789983e-01 4.186931e-01 19 49989666 49989695 30 - 2.230 2.259 0.096
ENSG00000105053 E021 281.7655464 0.0007944728 5.027098e-01 6.387310e-01 19 49989696 49989771 76 - 2.351 2.368 0.056
ENSG00000105053 E022 304.7516470 0.0004957691 3.857161e-01 5.299032e-01 19 49992860 49992952 93 - 2.383 2.403 0.067
ENSG00000105053 E023 199.4264320 0.0001873126 1.083859e-01 2.031520e-01 19 49994814 49994862 49 - 2.178 2.224 0.154
ENSG00000105053 E024 197.0270037 0.0002085378 1.996094e-02 5.140273e-02 19 49994863 49994919 57 - 2.154 2.223 0.232
ENSG00000105053 E025 113.9880328 0.0002934383 4.420016e-02 9.876378e-02 19 49995191 49995204 14 - 1.910 1.989 0.266
ENSG00000105053 E026 243.9006914 0.0001875211 6.909445e-05 3.756561e-04 19 49995205 49995275 71 - 2.211 2.321 0.368
ENSG00000105053 E027 1.8465044 0.5396225087 8.057158e-01 8.764934e-01 19 49997002 49997503 502 - 0.515 0.362 -0.803
ENSG00000105053 E028 225.0144510 0.0001951205 9.981055e-06 6.635136e-05 19 49997504 49997543 40 - 2.161 2.290 0.430
ENSG00000105053 E029 197.2030374 0.0002135329 1.435229e-03 5.423569e-03 19 49997544 49997570 27 - 2.131 2.228 0.325
ENSG00000105053 E030 4.3028932 0.0038123216 9.294137e-01 9.595847e-01 19 49997571 49999198 1628 - 0.645 0.657 0.052
ENSG00000105053 E031 2.5023600 0.0061923964 8.658385e-01 9.176070e-01 19 49999268 50000789 1522 - 0.515 0.484 -0.153
ENSG00000105053 E032 297.8426360 0.0001835816 4.666572e-01 6.062070e-01 19 50000790 50000854 65 - 2.374 2.389 0.052
ENSG00000105053 E033 1.4831208 0.1129342319 9.255463e-01 9.571274e-01 19 50000855 50001415 561 - 0.330 0.359 0.176
ENSG00000105053 E034 250.3405985 0.0002289460 4.959824e-02 1.084488e-01 19 50007569 50007608 40 - 2.353 2.300 -0.180
ENSG00000105053 E035 451.7689591 0.0001415262 1.236664e-02 3.441383e-02 19 50007609 50007777 169 - 2.607 2.556 -0.169
ENSG00000105053 E036 250.1969535 0.0002702429 2.668940e-02 6.534451e-02 19 50007778 50007826 49 - 2.358 2.297 -0.203
ENSG00000105053 E037 0.2214452 0.0391506062 1.000000e+00   19 50008756 50008811 56 - 0.000 0.074 8.780
ENSG00000105053 E038 160.3825548 0.0002595490 1.994237e-03 7.208453e-03 19 50009236 50009289 54 - 2.197 2.096 -0.339
ENSG00000105053 E039 223.9077452 0.0002371275 3.014601e-03 1.030825e-02 19 50009290 50009385 96 - 2.328 2.244 -0.279
ENSG00000105053 E040 0.1515154 0.0424552910 1.528318e-01   19 50015674 50015731 58 - 0.196 0.000 -11.550
ENSG00000105053 E041 0.6759915 0.5562036280 1.929378e-01 3.174664e-01 19 50015732 50015793 62 - 0.435 0.077 -3.158
ENSG00000105053 E042 1.1113191 0.1117151851 8.145931e-01 8.825468e-01 19 50015794 50016023 230 - 0.330 0.283 -0.312
ENSG00000105053 E043 382.9217484 0.0015115471 3.589543e-07 3.268109e-06 19 50016024 50016163 140 - 2.599 2.463 -0.455
ENSG00000105053 E044 1.5812911 0.2315178634 9.130492e-01 9.489074e-01 19 50020462 50020584 123 - 0.331 0.365 0.207
ENSG00000105053 E045 265.7077654 0.0007666527 1.393369e-08 1.672281e-07 19 50020585 50020647 63 - 2.454 2.299 -0.515
ENSG00000105053 E046 1.6241288 0.0092976096 9.050799e-02 1.759316e-01 19 50020648 50020649 2 - 0.585 0.286 -1.612
ENSG00000105053 E047 0.5117019 0.0236100806 4.363894e-01 5.784784e-01 19 50024915 50025266 352 - 0.000 0.193 10.525
ENSG00000105053 E048 26.5499947 0.0008841163 3.419572e-06 2.528305e-05 19 50025267 50025345 79 - 1.586 1.254 -1.147
ENSG00000105053 E049 154.0031077 0.0014455878 9.624749e-08 9.801010e-07 19 50025346 50025667 322 - 2.245 2.053 -0.642
ENSG00000105053 E050 0.1451727 0.0427115549 1.532468e-01   19 50025668 50025946 279 - 0.196 0.000 -11.546