ENSG00000105048

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000585321 ENSG00000105048 HEK293_OSMI2_2hA HEK293_TMG_2hB TNNT1 protein_coding protein_coding 22.40244 46.09128 12.20385 1.246109 0.1674157 -1.916289 11.758509 22.986537 5.912820 2.354272 0.5769239 -1.957061 0.53476667 0.4997667 0.4840000 -0.01576667 9.595382e-01 3.352819e-13 FALSE TRUE
ENST00000587465 ENSG00000105048 HEK293_OSMI2_2hA HEK293_TMG_2hB TNNT1 protein_coding protein_coding 22.40244 46.09128 12.20385 1.246109 0.1674157 -1.916289 3.630814 7.174128 3.179881 0.536698 0.4317971 -1.171310 0.17744167 0.1552667 0.2612667 0.10600000 5.678860e-02 3.352819e-13 FALSE TRUE
ENST00000589745 ENSG00000105048 HEK293_OSMI2_2hA HEK293_TMG_2hB TNNT1 protein_coding protein_coding 22.40244 46.09128 12.20385 1.246109 0.1674157 -1.916289 2.391367 6.840130 0.000000 1.702205 0.0000000 -9.419987 0.08364167 0.1475000 0.0000000 -0.14750000 3.352819e-13 3.352819e-13 FALSE TRUE
ENST00000593194 ENSG00000105048 HEK293_OSMI2_2hA HEK293_TMG_2hB TNNT1 protein_coding protein_coding 22.40244 46.09128 12.20385 1.246109 0.1674157 -1.916289 3.323833 7.152871 2.054773 3.685392 1.0406580 -1.794555 0.13575833 0.1556000 0.1675667 0.01196667 1.000000e+00 3.352819e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000105048 E001 0.5514428 0.0198564280 0.612974418 0.73178920 19 55132698 55132793 96 - 0.000 0.171 9.030
ENSG00000105048 E002 1.8746422 0.0081333665 0.338892120 0.48279875 19 55132794 55132825 32 - 0.219 0.417 1.292
ENSG00000105048 E003 1.8746422 0.0081333665 0.338892120 0.48279875 19 55132826 55132827 2 - 0.219 0.417 1.292
ENSG00000105048 E004 5.9300501 0.0028802915 0.021982313 0.05563697 19 55132828 55132834 7 - 0.364 0.789 1.971
ENSG00000105048 E005 20.1034876 0.0023955362 0.050693667 0.11039696 19 55132835 55132864 30 - 1.036 1.244 0.748
ENSG00000105048 E006 24.0085392 0.0012586755 0.009637085 0.02787312 19 55132865 55132875 11 - 1.061 1.321 0.924
ENSG00000105048 E007 85.6549934 0.0005222343 0.050202266 0.10951440 19 55132876 55132949 74 - 1.734 1.833 0.334
ENSG00000105048 E008 88.4268342 0.0004419200 0.162229856 0.27800958 19 55132950 55132960 11 - 1.775 1.842 0.229
ENSG00000105048 E009 0.1817044 0.0413549380 1.000000000   19 55133553 55133674 122 - 0.000 0.065 9.316
ENSG00000105048 E010 105.8548258 0.0004320529 0.048199339 0.10598719 19 55133887 55133927 41 - 1.833 1.922 0.300
ENSG00000105048 E011 163.2836843 0.0010694731 0.041891023 0.09452436 19 55134066 55134156 91 - 2.029 2.106 0.260
ENSG00000105048 E012 5.9237376 0.0075885022 0.706426037 0.80457321 19 55134157 55134204 48 - 0.796 0.740 -0.226
ENSG00000105048 E013 241.7084223 0.0001895360 0.383639691 0.52783648 19 55137103 55137212 110 - 2.242 2.266 0.080
ENSG00000105048 E014 135.6852222 0.0024958802 0.896667204 0.93795884 19 55137961 55137975 15 - 2.015 2.008 -0.026
ENSG00000105048 E015 159.4528446 0.0002744283 0.792069617 0.86701534 19 55137976 55138004 29 - 2.089 2.078 -0.035
ENSG00000105048 E016 131.1020366 0.0002944391 0.734064707 0.82513419 19 55138005 55138017 13 - 1.990 2.002 0.042
ENSG00000105048 E017 210.6745935 0.0002081905 0.344753257 0.48885116 19 55138018 55138074 57 - 2.227 2.198 -0.098
ENSG00000105048 E018 0.5921286 0.2916453319 0.714261245 0.81052074 19 55140652 55140699 48 - 0.219 0.166 -0.501
ENSG00000105048 E019 150.2664473 0.0003748722 0.285462308 0.42578637 19 55140883 55140912 30 - 2.091 2.052 -0.131
ENSG00000105048 E020 166.7255136 0.0002312469 0.444410955 0.58598738 19 55140913 55140960 48 - 2.124 2.097 -0.090
ENSG00000105048 E021 202.4648293 0.0002213313 0.039104085 0.08937940 19 55141186 55141302 117 - 2.237 2.174 -0.212
ENSG00000105048 E022 140.6541720 0.0022101871 0.797079270 0.87051219 19 55141857 55141920 64 - 2.018 2.026 0.027
ENSG00000105048 E023 1.0329558 0.0121989077 0.859721841 0.91352649 19 55141921 55142057 137 - 0.219 0.257 0.293
ENSG00000105048 E024 0.3697384 0.0274424043 1.000000000 1.00000000 19 55145400 55145543 144 - 0.000 0.121 10.412
ENSG00000105048 E025 99.7826593 0.0052027151 0.672133098 0.77821808 19 55145544 55145565 22 - 1.899 1.872 -0.089
ENSG00000105048 E026 23.8965744 0.0009155275 0.012971716 0.03584435 19 55146434 55146466 33 - 1.436 1.233 -0.707
ENSG00000105048 E027 1.4361053 0.0096767233 0.592233525 0.71482094 19 55146660 55146680 21 - 0.219 0.328 0.779
ENSG00000105048 E028 80.4770672 0.0050386240 0.328386645 0.47186682 19 55146681 55146705 25 - 1.833 1.773 -0.201
ENSG00000105048 E029 63.7663872 0.0042660823 0.391802926 0.53574132 19 55146706 55146707 2 - 1.729 1.673 -0.188
ENSG00000105048 E030 147.0443924 0.0056132475 0.861004358 0.91436103 19 55146708 55146949 242 - 2.052 2.041 -0.037
ENSG00000105048 E031 3.8300162 0.0043469689 0.034333191 0.08040050 19 55147008 55147021 14 - 0.840 0.513 -1.391
ENSG00000105048 E032 0.1482932 0.0411879425 1.000000000   19 55147105 55147125 21 - 0.000 0.065 9.314
ENSG00000105048 E033 3.1095545 0.0063151071 0.007595356 0.02276012 19 55147126 55147168 43 - 0.840 0.417 -1.877
ENSG00000105048 E034 1.3598197 0.0107030424 0.717598387 0.81292565 19 55147169 55147346 178 - 0.364 0.294 -0.444
ENSG00000105048 E035 0.0000000       19 55147999 55148093 95 -      
ENSG00000105048 E036 2.5893303 0.0061255818 0.220718003 0.35127494 19 55149161 55149206 46 - 0.632 0.417 -1.028