ENSG00000104980

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000270538 ENSG00000104980 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMM44 protein_coding protein_coding 86.33459 108.2041 66.31251 3.639242 2.673279 -0.7063185 60.777743 89.614572 40.091489 4.0963179 1.1920379 -1.1602385 0.68935417 0.82763333 0.60533333 -0.22230000 6.991130e-13 6.99113e-13 FALSE TRUE
ENST00000598675 ENSG00000104980 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMM44 protein_coding retained_intron 86.33459 108.2041 66.31251 3.639242 2.673279 -0.7063185 4.173947 2.577949 4.414596 0.3999602 0.1893144 0.7737363 0.05095417 0.02413333 0.06656667 0.04243333 1.772453e-04 6.99113e-13 FALSE TRUE
ENST00000600748 ENSG00000104980 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMM44 protein_coding retained_intron 86.33459 108.2041 66.31251 3.639242 2.673279 -0.7063185 6.740270 2.732010 9.274207 0.5743676 1.5546437 1.7595447 0.08525000 0.02563333 0.13846667 0.11283333 9.931797e-06 6.99113e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104980 E001 10.421097 0.0017050259 7.429786e-01 8.317580e-01 19 7926718 7926720 3 - 0.991 1.022 0.113
ENSG00000104980 E002 32.129812 0.0006524844 7.789400e-01 8.577930e-01 19 7926721 7926735 15 - 1.489 1.464 -0.085
ENSG00000104980 E003 285.918285 0.0002098369 5.974294e-20 3.762673e-18 19 7926736 7926913 178 - 2.232 2.460 0.761
ENSG00000104980 E004 471.942740 0.0014930537 5.095453e-13 1.309995e-11 19 7926914 7927048 135 - 2.483 2.668 0.616
ENSG00000104980 E005 906.452563 0.0002458741 2.950337e-18 1.531322e-16 19 7927049 7927306 258 - 2.816 2.939 0.407
ENSG00000104980 E006 26.059694 0.0216013720 5.664864e-01 6.934598e-01 19 7927307 7927656 350 - 1.430 1.367 -0.219
ENSG00000104980 E007 762.127928 0.0003265738 3.746395e-05 2.174766e-04 19 7927657 7927767 111 - 2.789 2.849 0.201
ENSG00000104980 E008 23.818335 0.0187282646 3.841742e-01 5.283467e-01 19 7927768 7927823 56 - 1.281 1.361 0.279
ENSG00000104980 E009 46.116740 0.0169585954 2.270696e-02 5.714431e-02 19 7927824 7928076 253 - 1.754 1.558 -0.665
ENSG00000104980 E010 564.980628 0.0006112780 8.141748e-01 8.822606e-01 19 7928077 7928122 46 - 2.711 2.701 -0.036
ENSG00000104980 E011 555.995293 0.0013939779 7.648635e-01 8.478223e-01 19 7928123 7928166 44 - 2.695 2.696 0.004
ENSG00000104980 E012 109.820687 0.0002946025 4.161787e-16 1.652217e-14 19 7928167 7928944 778 - 2.184 1.895 -0.968
ENSG00000104980 E013 560.988484 0.0010383203 1.592861e-01 2.741678e-01 19 7931138 7931188 51 - 2.726 2.689 -0.125
ENSG00000104980 E014 44.459977 0.0333065151 9.849559e-05 5.148354e-04 19 7931189 7931599 411 - 1.861 1.448 -1.401
ENSG00000104980 E015 22.607445 0.0406784375 6.140859e-03 1.898043e-02 19 7931679 7931830 152 - 1.541 1.202 -1.177
ENSG00000104980 E016 39.732869 0.0146481566 6.853508e-09 8.713352e-08 19 7932276 7932626 351 - 1.845 1.368 -1.626
ENSG00000104980 E017 618.043329 0.0001652470 7.454513e-01 8.334853e-01 19 7932627 7932698 72 - 2.750 2.738 -0.039
ENSG00000104980 E018 469.259444 0.0001200995 3.240737e-01 4.674386e-01 19 7932699 7932751 53 - 2.641 2.617 -0.080
ENSG00000104980 E019 559.663523 0.0001365310 2.756840e-01 4.150341e-01 19 7932840 7932932 93 - 2.717 2.692 -0.082
ENSG00000104980 E020 549.299103 0.0001153478 7.899789e-01 8.656521e-01 19 7933485 7933566 82 - 2.693 2.691 -0.006
ENSG00000104980 E021 319.712041 0.0003315027 4.530274e-01 5.938192e-01 19 7933567 7933570 4 - 2.475 2.452 -0.078
ENSG00000104980 E022 22.999229 0.0088103534 2.521389e-10 4.148598e-09 19 7933764 7933859 96 - 1.644 1.105 -1.873
ENSG00000104980 E023 13.618751 0.0013068753 1.541684e-04 7.656769e-04 19 7933860 7933863 4 - 1.343 0.995 -1.245
ENSG00000104980 E024 676.149052 0.0018434696 6.634769e-01 7.715341e-01 19 7933864 7934003 140 - 2.795 2.774 -0.069
ENSG00000104980 E025 682.391628 0.0008101303 1.682356e-01 2.859130e-01 19 7934089 7934238 150 - 2.810 2.775 -0.117
ENSG00000104980 E026 10.670592 0.0050705908 1.656045e-04 8.162685e-04 19 7934239 7934241 3 - 1.270 0.875 -1.440
ENSG00000104980 E027 548.301310 0.0015868792 2.281129e-02 5.734972e-02 19 7935065 7935145 81 - 2.736 2.670 -0.219
ENSG00000104980 E028 3.950080 0.0043792831 6.119841e-01 7.310169e-01 19 7935146 7935253 108 - 0.595 0.670 0.326
ENSG00000104980 E029 1.930382 0.0089166969 1.252879e-02 3.480420e-02 19 7937798 7938026 229 - 0.691 0.271 -2.176
ENSG00000104980 E030 621.264117 0.0019616326 1.456821e-02 3.951810e-02 19 7938027 7938197 171 - 2.794 2.721 -0.244
ENSG00000104980 E031 367.934012 0.0054724444 2.683588e-01 4.068125e-01 19 7941102 7941197 96 - 2.556 2.498 -0.193
ENSG00000104980 E032 258.213857 0.0073503272 2.209344e-01 3.515544e-01 19 7943607 7943667 61 - 2.412 2.340 -0.240