ENSG00000104964

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327141 ENSG00000104964 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE5 protein_coding protein_coding 106.3554 217.6135 59.83609 4.207623 2.078761 -1.862505 32.670092 58.56612 18.441523 1.2869265 0.2612601 -1.6665727 0.30950000 0.26950000 0.3091000 0.03960000 0.3488987416 0.0002689521 FALSE TRUE
ENST00000586839 ENSG00000104964 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE5 protein_coding protein_coding 106.3554 217.6135 59.83609 4.207623 2.078761 -1.862505 9.241026 13.02958 8.252738 3.1814318 1.4079238 -0.6582053 0.11212500 0.05936667 0.1383000 0.07893333 0.0876575921 0.0002689521 FALSE TRUE
ENST00000587393 ENSG00000104964 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE5 protein_coding retained_intron 106.3554 217.6135 59.83609 4.207623 2.078761 -1.862505 52.921370 124.09210 25.096441 1.4341647 2.0950459 -2.3053981 0.45848750 0.57053333 0.4182667 -0.15226667 0.0002689521 0.0002689521 FALSE TRUE
MSTRG.16146.5 ENSG00000104964 HEK293_OSMI2_2hA HEK293_TMG_2hB TLE5 protein_coding   106.3554 217.6135 59.83609 4.207623 2.078761 -1.862505 8.969756 18.81940 6.426335 0.9368928 0.4090796 -1.5486756 0.08857917 0.08640000 0.1072667 0.02086667 0.1027039552 0.0002689521 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104964 E001 55.764707 8.629710e-03 3.291539e-02 7.763501e-02 19 3052910 3052982 73 - 1.484 1.653 0.577
ENSG00000104964 E002 80.102337 8.614126e-03 1.612259e-02 4.300726e-02 19 3052983 3053027 45 - 1.635 1.805 0.576
ENSG00000104964 E003 380.039717 1.518247e-03 3.642088e-03 1.213284e-02 19 3053028 3053211 184 - 2.378 2.465 0.291
ENSG00000104964 E004 1202.885511 1.459797e-03 6.916095e-03 2.100777e-02 19 3053212 3053407 196 - 2.903 2.959 0.186
ENSG00000104964 E005 788.011347 1.278486e-04 8.734752e-06 5.882590e-05 19 3053408 3053458 51 - 2.705 2.778 0.244
ENSG00000104964 E006 1014.200392 2.646354e-04 8.119142e-08 8.393250e-07 19 3053459 3053548 90 - 2.804 2.889 0.281
ENSG00000104964 E007 706.650028 1.356074e-04 6.636448e-11 1.205769e-09 19 3053549 3053590 42 - 2.618 2.736 0.395
ENSG00000104964 E008 561.164282 1.393938e-04 9.433794e-08 9.623110e-07 19 3053591 3053603 13 - 2.528 2.635 0.358
ENSG00000104964 E009 2042.290572 6.473092e-04 9.602848e-04 3.822957e-03 19 3053604 3054022 419 - 3.142 3.186 0.146
ENSG00000104964 E010 756.771302 9.204005e-05 3.155192e-01 4.582861e-01 19 3054023 3054040 18 - 2.738 2.751 0.043
ENSG00000104964 E011 4.525184 1.464323e-01 3.009364e-01 4.427149e-01 19 3054041 3054119 79 - 0.846 0.594 -1.043
ENSG00000104964 E012 1033.540570 1.219050e-04 1.460689e-01 2.563409e-01 19 3054120 3054167 48 - 2.869 2.886 0.058
ENSG00000104964 E013 854.430671 1.174616e-04 2.021849e-02 5.194276e-02 19 3054168 3054194 27 - 2.834 2.793 -0.135
ENSG00000104964 E014 28.229312 7.138320e-03 5.433747e-07 4.772623e-06 19 3054195 3055663 1469 - 1.642 1.236 -1.402
ENSG00000104964 E015 1171.233713 7.824091e-05 2.674163e-03 9.295464e-03 19 3055664 3055726 63 - 2.974 2.930 -0.145
ENSG00000104964 E016 4.023350 5.070993e-03 9.023372e-04 3.621794e-03 19 3055727 3056196 470 - 0.956 0.462 -2.081
ENSG00000104964 E017 943.283284 5.225564e-04 1.431117e-05 9.169711e-05 19 3056312 3056356 45 - 2.909 2.830 -0.262
ENSG00000104964 E018 7.080172 1.104758e-02 9.699684e-02 1.858898e-01 19 3056357 3056768 412 - 0.987 0.758 -0.881
ENSG00000104964 E019 9.692710 2.111164e-03 1.017067e-04 5.297634e-04 19 3057440 3057678 239 - 1.232 0.794 -1.621
ENSG00000104964 E020 919.354551 8.292461e-04 4.918880e-10 7.709688e-09 19 3057679 3057742 64 - 2.932 2.810 -0.408
ENSG00000104964 E021 2.578545 2.302203e-02 9.808779e-01 9.920475e-01 19 3057743 3057748 6 - 0.478 0.483 0.023
ENSG00000104964 E022 1.107127 3.210529e-01 5.307632e-01 6.633035e-01 19 3060952 3061159 208 - 0.369 0.219 -1.027
ENSG00000104964 E023 765.099556 1.447435e-03 2.415429e-10 3.988806e-09 19 3061160 3061257 98 - 2.875 2.724 -0.502
ENSG00000104964 E024 3.240907 8.794621e-03 8.089418e-02 1.609363e-01 19 3061258 3061404 147 - 0.755 0.462 -1.303
ENSG00000104964 E025 290.026617 1.636620e-03 3.605205e-19 2.093151e-17 19 3062174 3062495 322 - 2.548 2.272 -0.920
ENSG00000104964 E026 10.372406 6.645560e-02 3.756038e-01 5.200281e-01 19 3062700 3063107 408 - 1.044 0.903 -0.522