ENSG00000104957

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221554 ENSG00000104957 HEK293_OSMI2_2hA HEK293_TMG_2hB YJU2B protein_coding protein_coding 26.27146 34.65763 18.82437 1.563416 0.9699517 -0.880221 10.403012 16.427630 6.221605 0.3823847 0.2741661 -1.3993265 0.38677917 0.47506667 0.33173333 -0.14333333 4.125189e-04 2.193795e-08 FALSE TRUE
ENST00000588071 ENSG00000104957 HEK293_OSMI2_2hA HEK293_TMG_2hB YJU2B protein_coding retained_intron 26.27146 34.65763 18.82437 1.563416 0.9699517 -0.880221 0.849852 0.000000 1.590507 0.0000000 0.6344677 7.3223847 0.03944167 0.00000000 0.08583333 0.08583333 2.193795e-08 2.193795e-08 FALSE TRUE
ENST00000589096 ENSG00000104957 HEK293_OSMI2_2hA HEK293_TMG_2hB YJU2B protein_coding protein_coding 26.27146 34.65763 18.82437 1.563416 0.9699517 -0.880221 2.144939 1.948171 1.525130 0.4581030 0.2473097 -0.3511461 0.08297500 0.05633333 0.08013333 0.02380000 5.053547e-01 2.193795e-08   FALSE
ENST00000589669 ENSG00000104957 HEK293_OSMI2_2hA HEK293_TMG_2hB YJU2B protein_coding processed_transcript 26.27146 34.65763 18.82437 1.563416 0.9699517 -0.880221 2.609567 3.139663 1.370274 0.3886282 0.3194188 -1.1902430 0.09245833 0.09096667 0.07156667 -0.01940000 6.985290e-01 2.193795e-08 FALSE FALSE
ENST00000593174 ENSG00000104957 HEK293_OSMI2_2hA HEK293_TMG_2hB YJU2B protein_coding retained_intron 26.27146 34.65763 18.82437 1.563416 0.9699517 -0.880221 4.970108 6.544973 4.368790 1.1696965 0.4955646 -0.5820575 0.19593333 0.18723333 0.23400000 0.04676667 6.485795e-01 2.193795e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104957 E001 0.2214452 0.0377673659 1.0000000000   19 13731760 13731760 1 + 0.000 0.089 8.114
ENSG00000104957 E002 0.9567573 0.2906124442 0.6988918482 0.798748599 19 13731761 13731761 1 + 0.286 0.234 -0.385
ENSG00000104957 E003 0.9567573 0.2906124442 0.6988918482 0.798748599 19 13731762 13731766 5 + 0.286 0.234 -0.385
ENSG00000104957 E004 0.9567573 0.2906124442 0.6988918482 0.798748599 19 13731767 13731767 1 + 0.286 0.234 -0.385
ENSG00000104957 E005 2.0263334 0.0101708190 0.7852829966 0.862366940 19 13731768 13731770 3 + 0.458 0.413 -0.233
ENSG00000104957 E006 2.1746266 0.0303354090 0.9461291606 0.970177867 19 13731771 13731771 1 + 0.458 0.451 -0.035
ENSG00000104957 E007 4.0847458 0.0042629234 0.6019265029 0.722978122 19 13731772 13731786 15 + 0.717 0.643 -0.308
ENSG00000104957 E008 18.6678727 0.0151915329 0.3381846181 0.482066072 19 13731787 13731931 145 + 1.314 1.222 -0.323
ENSG00000104957 E009 10.8590104 0.0041786890 0.1607630031 0.276115289 19 13731932 13731950 19 + 1.134 0.992 -0.516
ENSG00000104957 E010 12.4717171 0.0225291890 0.0080709652 0.023960575 19 13731951 13732068 118 + 1.284 0.982 -1.085
ENSG00000104957 E011 3.0884235 0.0170626677 0.1419755332 0.250744293 19 13732069 13732080 12 + 0.717 0.484 -1.039
ENSG00000104957 E012 29.3758697 0.0007561331 0.0323610771 0.076555393 19 13732175 13732285 111 + 1.528 1.390 -0.473
ENSG00000104957 E013 3.4957613 0.0282710815 0.1187177116 0.218104465 19 13732286 13732602 317 + 0.381 0.668 1.381
ENSG00000104957 E014 0.1472490 0.0427776843 0.2360660117   19 13747864 13747864 1 + 0.167 0.000 -12.512
ENSG00000104957 E015 1.9196841 0.0072099771 0.2129479493 0.342003155 19 13747865 13747872 8 + 0.580 0.373 -1.046
ENSG00000104957 E016 6.5067704 0.0027343045 0.0787438369 0.157501807 19 13747873 13747894 22 + 0.974 0.760 -0.822
ENSG00000104957 E017 7.0571690 0.0029192519 0.0891280385 0.173798186 19 13747895 13747896 2 + 0.995 0.793 -0.769
ENSG00000104957 E018 65.3175508 0.0022443678 0.0373991781 0.086223987 19 13747897 13747954 58 + 1.840 1.741 -0.335
ENSG00000104957 E019 215.8540402 0.0022678456 0.0051711279 0.016393425 19 13751608 13751811 204 + 2.347 2.263 -0.280
ENSG00000104957 E020 157.1205044 0.0024694434 0.0457662617 0.101605252 19 13754289 13754342 54 + 2.200 2.132 -0.228
ENSG00000104957 E021 117.6790764 0.0002810425 0.4571664950 0.597528863 19 13756197 13756207 11 + 2.041 2.020 -0.070
ENSG00000104957 E022 180.2296409 0.0006538717 0.0042144228 0.013742688 19 13756208 13756279 72 + 2.267 2.189 -0.260
ENSG00000104957 E023 154.1657251 0.0007894621 0.2044186135 0.331687391 19 13757418 13757473 56 + 2.168 2.133 -0.119
ENSG00000104957 E024 159.9408001 0.0002488032 0.5162703617 0.650850255 19 13757786 13757846 61 + 2.171 2.157 -0.047
ENSG00000104957 E025 134.8028323 0.0002420406 0.0505426077 0.110122431 19 13758868 13758907 40 + 2.036 2.106 0.236
ENSG00000104957 E026 179.1830329 0.0002105661 0.0433790648 0.097255871 19 13758908 13759010 103 + 2.161 2.225 0.212
ENSG00000104957 E027 52.8298843 0.0039387497 0.0316170215 0.075107523 19 13759011 13759075 65 + 1.760 1.642 -0.400
ENSG00000104957 E028 42.1491414 0.0006499797 0.0017703921 0.006505081 19 13759076 13759099 24 + 1.700 1.530 -0.579
ENSG00000104957 E029 96.3135437 0.0002907123 0.0458616921 0.101783718 19 13759100 13759110 11 + 1.880 1.964 0.284
ENSG00000104957 E030 95.3068380 0.0003307431 0.0504691221 0.109999242 19 13759111 13759116 6 + 1.874 1.958 0.281
ENSG00000104957 E031 201.7307962 0.0002098617 0.0102416866 0.029360018 19 13759117 13759272 156 + 2.204 2.279 0.252
ENSG00000104957 E032 22.6902041 0.0211850376 0.5021896139 0.638259453 19 13759273 13759627 355 + 1.379 1.315 -0.222
ENSG00000104957 E033 17.3137860 0.0064400782 0.2423129055 0.376901344 19 13761391 13761490 100 + 1.134 1.254 0.426
ENSG00000104957 E034 25.2390419 0.0014360256 0.3971837784 0.540967082 19 13761491 13761568 78 + 1.324 1.394 0.242
ENSG00000104957 E035 198.6168530 0.0029426079 0.0562266469 0.120102035 19 13762299 13762437 139 + 2.199 2.276 0.258
ENSG00000104957 E036 18.3718208 0.0011254026 0.0223610321 0.056430404 19 13762438 13762589 152 + 1.370 1.190 -0.631
ENSG00000104957 E037 401.5500063 0.0033172934 0.0002270751 0.001079407 19 13762590 13763296 707 + 2.471 2.592 0.402