ENSG00000104946

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221543 ENSG00000104946 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D17 protein_coding protein_coding 15.43043 22.78273 8.931713 1.160229 0.4121861 -1.34995 4.523912 9.444722 2.0855632 0.5072210 0.12396199 -2.173697067 0.25132917 0.41526667 0.23550000 -0.17976667 3.860334e-04 1.588324e-05 FALSE TRUE
ENST00000598789 ENSG00000104946 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D17 protein_coding processed_transcript 15.43043 22.78273 8.931713 1.160229 0.4121861 -1.34995 1.488489 1.871339 1.0564045 0.2019114 0.22536715 -0.819004865 0.09827500 0.08176667 0.11643333 0.03466667 3.820418e-01 1.588324e-05 FALSE FALSE
ENST00000599049 ENSG00000104946 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D17 protein_coding protein_coding 15.43043 22.78273 8.931713 1.160229 0.4121861 -1.34995 2.709320 4.343314 1.2579450 0.5278005 0.21926010 -1.779621953 0.17590833 0.19176667 0.13966667 -0.05210000 4.846971e-01 1.588324e-05 FALSE TRUE
ENST00000600354 ENSG00000104946 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D17 protein_coding retained_intron 15.43043 22.78273 8.931713 1.160229 0.4121861 -1.34995 1.014005 1.103093 0.5735058 0.2592219 0.05825595 -0.931755902 0.07027500 0.04766667 0.06430000 0.01663333 5.923187e-01 1.588324e-05 FALSE TRUE
MSTRG.17526.1 ENSG00000104946 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D17 protein_coding   15.43043 22.78273 8.931713 1.160229 0.4121861 -1.34995 1.035142 1.371309 0.7562020 0.1320577 0.08232446 -0.850239707 0.07113333 0.06000000 0.08456667 0.02456667 3.171829e-01 1.588324e-05 FALSE TRUE
MSTRG.17526.3 ENSG00000104946 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D17 protein_coding   15.43043 22.78273 8.931713 1.160229 0.4121861 -1.34995 2.652881 2.810173 1.5471527 0.2385874 0.02348758 -0.856873411 0.18348750 0.12346667 0.17403333 0.05056667 1.366484e-01 1.588324e-05 TRUE TRUE
MSTRG.17526.8 ENSG00000104946 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D17 protein_coding   15.43043 22.78273 8.931713 1.160229 0.4121861 -1.34995 1.803387 1.666475 1.6549402 0.2712532 0.07111361 -0.009960574 0.13847500 0.07246667 0.18553333 0.11306667 1.588324e-05 1.588324e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104946 E001 0.000000       19 49876130 49876154 25 +      
ENSG00000104946 E002 32.110808 0.0008486518 2.270898e-02 5.714862e-02 19 49876390 49877665 1276 + 1.551 1.404 -0.506
ENSG00000104946 E003 29.390965 0.0007453512 7.991180e-02 1.594272e-01 19 49877666 49877701 36 + 1.494 1.376 -0.405
ENSG00000104946 E004 38.881029 0.0005553494 8.823731e-03 2.584181e-02 19 49877702 49877719 18 + 1.636 1.482 -0.525
ENSG00000104946 E005 42.579372 0.0005441164 2.913412e-02 7.025881e-02 19 49877720 49877744 25 + 1.652 1.529 -0.418
ENSG00000104946 E006 8.056711 0.0020661042 2.138736e-01 3.431000e-01 19 49878076 49878142 67 + 0.990 0.844 -0.551
ENSG00000104946 E007 68.811549 0.0003808871 6.241927e-02 1.307180e-01 19 49878143 49878186 44 + 1.825 1.743 -0.278
ENSG00000104946 E008 81.919653 0.0004405106 1.644173e-01 2.809296e-01 19 49878187 49878241 55 + 1.882 1.826 -0.186
ENSG00000104946 E009 78.621975 0.0005124248 5.477907e-01 6.777780e-01 19 49878498 49878549 52 + 1.839 1.818 -0.072
ENSG00000104946 E010 65.297602 0.0005841208 2.740077e-01 4.131081e-01 19 49878550 49878572 23 + 1.780 1.732 -0.163
ENSG00000104946 E011 48.408527 0.0023029464 9.367054e-13 2.310324e-11 19 49878573 49879322 750 + 1.878 1.489 -1.323
ENSG00000104946 E012 22.861219 0.0009427922 1.641458e-06 1.300692e-05 19 49879323 49879504 182 + 1.544 1.195 -1.212
ENSG00000104946 E013 122.101485 0.0002884197 3.049818e-01 4.470105e-01 19 49880279 49880402 124 + 2.035 2.004 -0.104
ENSG00000104946 E014 52.217708 0.0004943105 5.910338e-01 7.138322e-01 19 49881268 49881273 6 + 1.668 1.644 -0.080
ENSG00000104946 E015 129.074776 0.0002840387 8.534279e-01 9.092870e-01 19 49881274 49881475 202 + 2.033 2.033 -0.001
ENSG00000104946 E016 117.671114 0.0005605548 3.971154e-01 5.408934e-01 19 49882041 49882152 112 + 2.011 1.985 -0.087
ENSG00000104946 E017 77.944194 0.0022641096 5.557970e-01 6.846035e-01 19 49882242 49882265 24 + 1.832 1.809 -0.078
ENSG00000104946 E018 132.745697 0.0002467760 4.363425e-01 5.784337e-01 19 49882266 49882400 135 + 2.020 2.054 0.114
ENSG00000104946 E019 126.129337 0.0003053267 1.447774e-01 2.545228e-01 19 49882764 49882892 129 + 1.977 2.037 0.203
ENSG00000104946 E020 115.604154 0.0004889777 7.532162e-01 8.392464e-01 19 49882973 49883076 104 + 1.974 1.993 0.062
ENSG00000104946 E021 121.892000 0.0020692570 2.697293e-01 4.082726e-01 19 49883651 49883745 95 + 1.969 2.024 0.184
ENSG00000104946 E022 169.885805 0.0011832511 1.653018e-01 2.820696e-01 19 49884253 49884369 117 + 2.112 2.168 0.187
ENSG00000104946 E023 162.906555 0.0026225467 2.629064e-01 4.007340e-01 19 49884459 49884559 101 + 2.097 2.149 0.175
ENSG00000104946 E024 153.801858 0.0005649444 3.249631e-03 1.100071e-02 19 49884659 49884758 100 + 2.024 2.135 0.370
ENSG00000104946 E025 28.786745 0.0039592143 8.866840e-02 1.730875e-01 19 49885172 49885530 359 + 1.281 1.429 0.515
ENSG00000104946 E026 4.644536 0.0045521050 2.935482e-02 7.068912e-02 19 49885531 49885534 4 + 0.910 0.611 -1.208
ENSG00000104946 E027 29.530862 0.0020806096 5.121587e-02 1.113166e-01 19 49886551 49887475 925 + 1.501 1.366 -0.465
ENSG00000104946 E028 120.890256 0.0110547228 3.511588e-02 8.186456e-02 19 49887476 49887573 98 + 1.890 2.035 0.487
ENSG00000104946 E029 104.456717 0.0060659943 9.259028e-03 2.693097e-02 19 49887718 49887834 117 + 1.814 1.972 0.531
ENSG00000104946 E030 14.110382 0.0012513617 2.611222e-01 3.987523e-01 19 49888157 49888174 18 + 1.184 1.079 -0.374
ENSG00000104946 E031 16.991073 0.0012541055 5.350489e-01 6.669962e-01 19 49888175 49888230 56 + 1.214 1.162 -0.183
ENSG00000104946 E032 79.176187 0.0021718295 2.594545e-02 6.383491e-02 19 49888231 49888317 87 + 1.721 1.845 0.422
ENSG00000104946 E033 63.458017 0.0054154398 6.742228e-03 2.055379e-02 19 49888424 49888870 447 + 1.577 1.762 0.630