ENSG00000104907

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000437766 ENSG00000104907 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT1 protein_coding protein_coding 70.79412 99.67646 53.83003 5.102232 2.519584 -0.8887183 27.452924 43.638602 14.081685 2.2721571 0.1295977 -1.6310913 0.37136667 0.43803333 0.2625 -0.17553333 3.305176e-12 3.305176e-12 FALSE TRUE
ENST00000586830 ENSG00000104907 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT1 protein_coding retained_intron 70.79412 99.67646 53.83003 5.102232 2.519584 -0.8887183 4.442947 4.672612 5.801324 0.7603964 0.7991034 0.3115533 0.06713750 0.04676667 0.1074 0.06063333 5.243619e-03 3.305176e-12 FALSE FALSE
ENST00000588511 ENSG00000104907 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT1 protein_coding retained_intron 70.79412 99.67646 53.83003 5.102232 2.519584 -0.8887183 3.442268 2.722104 3.268815 0.4378018 0.3965448 0.2631623 0.05223333 0.02720000 0.0604 0.03320000 2.135289e-03 3.305176e-12 TRUE TRUE
ENST00000593157 ENSG00000104907 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT1 protein_coding retained_intron 70.79412 99.67646 53.83003 5.102232 2.519584 -0.8887183 5.744498 7.313577 6.138471 1.0076557 0.9808250 -0.2523208 0.08357500 0.07283333 0.1129 0.04006667 8.945282e-02 3.305176e-12 TRUE TRUE
MSTRG.16552.1 ENSG00000104907 HEK293_OSMI2_2hA HEK293_TMG_2hB TRMT1 protein_coding   70.79412 99.67646 53.83003 5.102232 2.519584 -0.8887183 21.166825 33.000463 16.238157 1.4790642 0.6923739 -1.0226473 0.29867500 0.33133333 0.3018 -0.02953333 2.062778e-01 3.305176e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104907 E001 1.140451 0.0109921488 9.432316e-01 9.683965e-01 19 13104901 13104901 1 - 0.300 0.314 0.089
ENSG00000104907 E002 4.452217 0.0037195656 2.233722e-01 3.544213e-01 19 13104902 13104906 5 - 0.543 0.737 0.838
ENSG00000104907 E003 80.307276 0.0089797224 5.198371e-03 1.646987e-02 19 13104907 13104938 32 - 1.710 1.899 0.636
ENSG00000104907 E004 353.697524 0.0003132830 1.049536e-10 1.845646e-09 19 13104939 13105081 143 - 2.374 2.527 0.511
ENSG00000104907 E005 596.328701 0.0002822813 1.094658e-18 6.012746e-17 19 13105267 13105396 130 - 2.588 2.755 0.557
ENSG00000104907 E006 113.559026 0.0074041694 8.990278e-05 4.745427e-04 19 13105397 13105486 90 - 2.145 1.935 -0.703
ENSG00000104907 E007 673.854937 0.0023712124 8.317725e-06 5.629150e-05 19 13105487 13105606 120 - 2.675 2.803 0.426
ENSG00000104907 E008 423.501513 0.0019333955 1.290476e-04 6.547139e-04 19 13107574 13107601 28 - 2.484 2.598 0.382
ENSG00000104907 E009 539.157460 0.0011656706 2.993245e-03 1.024409e-02 19 13107602 13107650 49 - 2.619 2.693 0.244
ENSG00000104907 E010 6.509991 0.0236048552 1.106736e-01 2.065225e-01 19 13107651 13107750 100 - 0.976 0.755 -0.855
ENSG00000104907 E011 458.694397 0.0011103091 8.018736e-02 1.598406e-01 19 13107751 13107774 24 - 2.570 2.616 0.152
ENSG00000104907 E012 675.116080 0.0005104688 1.314763e-03 5.026291e-03 19 13107775 13107859 85 - 2.725 2.787 0.206
ENSG00000104907 E013 622.253297 0.0009679370 1.912388e-01 3.152897e-01 19 13109381 13109466 86 - 2.714 2.745 0.103
ENSG00000104907 E014 522.056764 0.0005208324 4.771887e-01 6.157963e-01 19 13109550 13109644 95 - 2.649 2.665 0.052
ENSG00000104907 E015 358.140235 0.0002586145 9.370491e-01 9.644324e-01 19 13109645 13109684 40 - 2.495 2.498 0.009
ENSG00000104907 E016 26.001999 0.0017185715 1.491665e-03 5.609311e-03 19 13109685 13109732 48 - 1.524 1.295 -0.792
ENSG00000104907 E017 461.426337 0.0001293138 7.111911e-01 8.081880e-01 19 13109769 13109838 70 - 2.599 2.607 0.026
ENSG00000104907 E018 293.060909 0.0001724046 8.543718e-01 9.098933e-01 19 13109915 13110001 87 - 2.411 2.407 -0.012
ENSG00000104907 E019 302.410105 0.0001909178 8.330450e-01 8.953834e-01 19 13110158 13110185 28 - 2.417 2.423 0.019
ENSG00000104907 E020 529.684470 0.0001899678 4.108423e-02 9.303852e-02 19 13110186 13110306 121 - 2.635 2.673 0.127
ENSG00000104907 E021 543.489009 0.0004953497 8.934249e-01 9.358849e-01 19 13112705 13112817 113 - 2.676 2.675 -0.003
ENSG00000104907 E022 276.637200 0.0006288541 2.615035e-01 3.991472e-01 19 13112896 13112908 13 - 2.403 2.374 -0.095
ENSG00000104907 E023 399.079943 0.0002742141 5.784123e-03 1.804474e-02 19 13112909 13112954 46 - 2.583 2.526 -0.188
ENSG00000104907 E024 413.828085 0.0001567490 8.038519e-03 2.387632e-02 19 13112955 13113000 46 - 2.597 2.546 -0.171
ENSG00000104907 E025 320.482260 0.0001433732 2.827172e-02 6.854705e-02 19 13113001 13113011 11 - 2.483 2.435 -0.159
ENSG00000104907 E026 632.193141 0.0001360646 1.034750e-01 1.957875e-01 19 13115279 13115378 100 - 2.760 2.734 -0.085
ENSG00000104907 E027 392.810659 0.0001879532 8.604886e-01 9.140183e-01 19 13115379 13115402 24 - 2.537 2.534 -0.010
ENSG00000104907 E028 346.910842 0.0001683848 5.649533e-01 6.921533e-01 19 13115403 13115422 20 - 2.471 2.484 0.044
ENSG00000104907 E029 339.726215 0.0001426936 8.796979e-01 9.267839e-01 19 13115423 13115440 18 - 2.469 2.473 0.013
ENSG00000104907 E030 340.279414 0.0001433317 8.033098e-01 8.747751e-01 19 13115441 13115457 17 - 2.477 2.472 -0.016
ENSG00000104907 E031 326.098279 0.0001519740 5.904934e-01 7.133432e-01 19 13115458 13115463 6 - 2.464 2.452 -0.038
ENSG00000104907 E032 315.309535 0.0001603498 4.344578e-01 5.768341e-01 19 13115464 13115466 3 - 2.453 2.436 -0.057
ENSG00000104907 E033 283.629169 0.0001683090 3.174416e-01 4.603224e-01 19 13115626 13115626 1 - 2.376 2.401 0.082
ENSG00000104907 E034 549.297698 0.0001163613 1.749529e-01 2.946082e-01 19 13115627 13115701 75 - 2.664 2.688 0.080
ENSG00000104907 E035 544.599049 0.0004222846 2.287903e-01 3.610104e-01 19 13115702 13115768 67 - 2.694 2.672 -0.074
ENSG00000104907 E036 22.859088 0.0008149462 1.226096e-10 2.132968e-09 19 13115769 13115835 67 - 1.612 1.151 -1.600
ENSG00000104907 E037 20.208524 0.0009002220 2.775903e-13 7.416254e-12 19 13115836 13115870 35 - 1.601 1.049 -1.932
ENSG00000104907 E038 21.942377 0.0043678051 4.500266e-12 9.910054e-11 19 13115871 13115946 76 - 1.632 1.095 -1.871
ENSG00000104907 E039 16.084058 0.0090956463 2.127867e-08 2.468725e-07 19 13115947 13115996 50 - 1.497 0.977 -1.843
ENSG00000104907 E040 531.720919 0.0013797416 1.024571e-01 1.942592e-01 19 13115997 13116052 56 - 2.696 2.658 -0.127
ENSG00000104907 E041 21.846709 0.0012931883 3.701449e-14 1.119458e-12 19 13116053 13116105 53 - 1.637 1.081 -1.941
ENSG00000104907 E042 27.662783 0.0068651821 2.423323e-10 4.000795e-09 19 13116106 13116145 40 - 1.702 1.227 -1.640
ENSG00000104907 E043 443.639707 0.0010560644 1.609888e-03 5.992741e-03 19 13116146 13116171 26 - 2.642 2.569 -0.246
ENSG00000104907 E044 347.291988 0.0008403249 8.790078e-04 3.540457e-03 19 13116172 13116186 15 - 2.541 2.460 -0.270
ENSG00000104907 E045 726.136830 0.0016225555 8.706717e-05 4.612975e-04 19 13116187 13116340 154 - 2.868 2.778 -0.301
ENSG00000104907 E046 435.999244 0.0026670586 9.322952e-02 1.801703e-01 19 13116341 13116431 91 - 2.618 2.569 -0.163
ENSG00000104907 E047 27.698213 0.0007156332 6.543339e-01 7.645202e-01 19 13116432 13116652 221 - 1.379 1.412 0.115
ENSG00000104907 E048 271.864139 0.0001544534 4.862493e-07 4.309838e-06 19 13116653 13117112 460 - 2.460 2.343 -0.391
ENSG00000104907 E049 1.103932 0.0121162528 4.716796e-01 6.107546e-01 19 13117489 13117567 79 - 0.397 0.267 -0.818