ENSG00000104884

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000391942 ENSG00000104884 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC2 protein_coding retained_intron 42.17047 59.79198 28.22465 3.567318 0.8586376 -1.082727 3.788161 2.812413 4.638193 0.3337797 0.2412923 0.7197411 0.1033250 0.04683333 0.1648333 0.11800000 3.770218e-14 3.770218e-14 FALSE TRUE
ENST00000391945 ENSG00000104884 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC2 protein_coding protein_coding 42.17047 59.79198 28.22465 3.567318 0.8586376 -1.082727 25.921955 42.047528 13.630843 1.3563961 0.4087501 -1.6244312 0.5895958 0.70576667 0.4833667 -0.22240000 5.639571e-07 3.770218e-14 FALSE TRUE
MSTRG.17318.9 ENSG00000104884 HEK293_OSMI2_2hA HEK293_TMG_2hB ERCC2 protein_coding   42.17047 59.79198 28.22465 3.567318 0.8586376 -1.082727 4.284087 5.264559 3.556868 0.7926245 0.6070135 -0.5643926 0.1061958 0.08706667 0.1249333 0.03786667 3.391814e-01 3.770218e-14 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104884 E001 39.8101423 0.0131697015 1.492386e-03 5.611575e-03 19 45349837 45349846 10 - 1.300 1.603 1.042
ENSG00000104884 E002 761.4657148 0.0068333531 1.054837e-09 1.557202e-08 19 45349847 45350412 566 - 2.590 2.865 0.914
ENSG00000104884 E003 532.5474053 0.0002318689 6.619567e-13 1.673415e-11 19 45350413 45350854 442 - 2.534 2.687 0.509
ENSG00000104884 E004 193.9869305 0.0003196534 8.377555e-01 8.985783e-01 19 45350855 45350889 35 - 2.213 2.218 0.016
ENSG00000104884 E005 412.6761647 0.0007361093 6.024819e-01 7.234435e-01 19 45350890 45351030 141 - 2.527 2.551 0.082
ENSG00000104884 E006 660.1257213 0.0012517387 1.202794e-03 4.650131e-03 19 45351031 45351467 437 - 2.682 2.770 0.293
ENSG00000104884 E007 325.7135522 0.0001685678 2.016711e-02 5.183400e-02 19 45351468 45351593 126 - 2.392 2.458 0.218
ENSG00000104884 E008 134.2436009 0.0009800345 1.471347e-01 2.577915e-01 19 45351594 45351594 1 - 2.007 2.075 0.226
ENSG00000104884 E009 384.2502673 0.0001731100 2.027083e-02 5.205423e-02 19 45351595 45351721 127 - 2.465 2.526 0.205
ENSG00000104884 E010 26.3797712 0.0040422493 1.373373e-05 8.834981e-05 19 45351722 45352208 487 - 1.585 1.271 -1.083
ENSG00000104884 E011 502.6488605 0.0001526008 2.875508e-03 9.898722e-03 19 45352209 45352352 144 - 2.576 2.644 0.227
ENSG00000104884 E012 522.5647636 0.0013674644 9.292388e-01 9.595059e-01 19 45352506 45352649 144 - 2.635 2.652 0.055
ENSG00000104884 E013 341.1194045 0.0014290747 1.811623e-01 3.026780e-01 19 45352746 45352816 71 - 2.482 2.458 -0.080
ENSG00000104884 E014 305.1067579 0.0005374816 6.175554e-01 7.353351e-01 19 45353083 45353149 67 - 2.416 2.415 -0.003
ENSG00000104884 E015 196.3904438 0.0001987441 9.475728e-01 9.710222e-01 19 45353150 45353155 6 - 2.216 2.225 0.030
ENSG00000104884 E016 309.9554588 0.0001534147 4.795731e-01 6.179430e-01 19 45353242 45353334 93 - 2.425 2.420 -0.018
ENSG00000104884 E017 390.5480244 0.0001873749 7.583132e-03 2.272780e-02 19 45354730 45354851 122 - 2.555 2.511 -0.147
ENSG00000104884 E018 306.8198558 0.0001623912 1.940477e-02 5.021008e-02 19 45355665 45355728 64 - 2.450 2.407 -0.143
ENSG00000104884 E019 378.9804721 0.0001479731 1.530233e-03 5.734879e-03 19 45357270 45357371 102 - 2.549 2.495 -0.181
ENSG00000104884 E020 312.1024546 0.0002193191 1.502781e-03 5.644949e-03 19 45357474 45357543 70 - 2.471 2.409 -0.206
ENSG00000104884 E021 14.1834265 0.0012940433 2.872081e-03 9.889441e-03 19 45357544 45357629 86 - 1.301 1.035 -0.948
ENSG00000104884 E022 258.8024733 0.0001978511 2.287690e-03 8.112840e-03 19 45357630 45357699 70 - 2.392 2.327 -0.217
ENSG00000104884 E023 17.3099771 0.0033208772 3.628618e-08 4.019593e-07 19 45357700 45358758 1059 - 1.492 1.035 -1.610
ENSG00000104884 E024 11.3254706 0.0149377498 2.051782e-01 3.326378e-01 19 45358759 45358912 154 - 1.135 0.999 -0.494
ENSG00000104884 E025 2.4305297 0.0072632002 7.385238e-02 1.496728e-01 19 45358913 45358938 26 - 0.671 0.382 -1.390
ENSG00000104884 E026 282.4299715 0.0002105361 3.475139e-02 8.117112e-02 19 45361524 45361642 119 - 2.410 2.370 -0.134
ENSG00000104884 E027 14.1888944 0.0013523347 1.807827e-08 2.124611e-07 19 45361643 45361931 289 - 1.429 0.936 -1.759
ENSG00000104884 E028 263.2023901 0.0030515264 8.432674e-01 9.023943e-01 19 45363743 45363911 169 - 2.334 2.356 0.073
ENSG00000104884 E029 157.1808829 0.0061177352 9.274349e-01 9.583379e-01 19 45363986 45364036 51 - 2.118 2.130 0.041
ENSG00000104884 E030 188.9686511 0.0110176453 8.752930e-01 9.239106e-01 19 45364037 45364090 54 - 2.200 2.210 0.034
ENSG00000104884 E031 169.6247888 0.0102632785 7.034063e-01 8.020939e-01 19 45364091 45364119 29 - 2.165 2.160 -0.019
ENSG00000104884 E032 136.7554871 0.0155175636 6.234170e-01 7.400076e-01 19 45364235 45364235 1 - 2.085 2.064 -0.070
ENSG00000104884 E033 288.6901881 0.0045844232 1.854419e-01 3.080568e-01 19 45364236 45364331 96 - 2.419 2.381 -0.125
ENSG00000104884 E034 285.5270943 0.0028252857 5.075751e-01 6.430420e-01 19 45364424 45364547 124 - 2.392 2.383 -0.029
ENSG00000104884 E035 232.8247692 0.0007544903 3.456483e-01 4.897684e-01 19 45364838 45364954 117 - 2.307 2.292 -0.053
ENSG00000104884 E036 249.6655551 0.0024320068 3.791030e-02 8.718020e-02 19 45365042 45365158 117 - 2.369 2.312 -0.192
ENSG00000104884 E037 272.4903647 0.0002238223 3.622993e-05 2.109880e-04 19 45368630 45368743 114 - 2.430 2.340 -0.299
ENSG00000104884 E038 2.1830733 0.0107767881 1.502677e-01 2.620448e-01 19 45368744 45368746 3 - 0.620 0.381 -1.170
ENSG00000104884 E039 239.9009560 0.0027878859 2.483856e-04 1.168481e-03 19 45368930 45368992 63 - 2.397 2.281 -0.388
ENSG00000104884 E040 8.9689730 0.0351212202 3.268108e-02 7.716594e-02 19 45368993 45369069 77 - 1.118 0.840 -1.035
ENSG00000104884 E041 205.5882641 0.0021172417 3.122322e-03 1.062537e-02 19 45369070 45369147 78 - 2.311 2.221 -0.301
ENSG00000104884 E042 216.9576047 0.0021910257 1.888845e-03 6.879611e-03 19 45370133 45370232 100 - 2.337 2.242 -0.318
ENSG00000104884 E043 64.8783693 0.0024070452 1.383732e-01 2.458282e-01 19 45370233 45370470 238 - 1.797 1.729 -0.230
ENSG00000104884 E044 0.4407149 0.0228641988 1.571326e-01 2.712843e-01 19 45370471 45370535 65 - 0.313 0.079 -2.394
ENSG00000104884 E045 66.2011724 0.0010289837 3.369401e-02 7.914434e-02 19 45370536 45370918 383 - 1.826 1.731 -0.318