ENSG00000104880

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000594665 ENSG00000104880 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF18 protein_coding protein_coding 14.71878 21.37503 10.7127 1.493939 0.5334602 -0.9959325 8.0365630 13.11229436 5.223988 1.78965092 0.39136747 -1.3260374 0.52623333 0.6078667 0.49330000 -0.114566667 0.4312534409 0.0009043975 FALSE  
ENST00000617428 ENSG00000104880 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF18 protein_coding protein_coding 14.71878 21.37503 10.7127 1.493939 0.5334602 -0.9959325 2.0913818 2.62592526 1.520590 0.28443573 0.03262502 -0.7842218 0.14825000 0.1233000 0.14233333 0.019033333 0.6944211449 0.0009043975 FALSE  
MSTRG.16306.3 ENSG00000104880 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF18 protein_coding   14.71878 21.37503 10.7127 1.493939 0.5334602 -0.9959325 0.5433126 0.05121574 1.071852 0.02470607 0.53366415 4.1434570 0.04824167 0.0023000 0.09583333 0.093533333 0.0009043975 0.0009043975 FALSE  
MSTRG.16306.4 ENSG00000104880 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF18 protein_coding   14.71878 21.37503 10.7127 1.493939 0.5334602 -0.9959325 4.0106540 5.40655494 2.890474 0.55640589 0.35927692 -0.9010868 0.27532917 0.2590667 0.26790000 0.008833333 0.9503505881 0.0009043975 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104880 E001 0.0000000       19 7348937 7349241 305 +      
ENSG00000104880 E002 0.0000000       19 7355616 7355703 88 +      
ENSG00000104880 E003 0.0000000       19 7362781 7362905 125 +      
ENSG00000104880 E004 0.0000000       19 7372812 7373071 260 +      
ENSG00000104880 E005 0.0000000       19 7375720 7375870 151 +      
ENSG00000104880 E006 0.0000000       19 7376643 7376757 115 +      
ENSG00000104880 E007 0.0000000       19 7378394 7378451 58 +      
ENSG00000104880 E008 0.0000000       19 7379122 7379166 45 +      
ENSG00000104880 E009 0.0000000       19 7380917 7380994 78 +      
ENSG00000104880 E010 0.0000000       19 7382792 7382894 103 +      
ENSG00000104880 E011 0.1472490 0.0433517885 2.266406e-01   19 7383062 7383203 142 + 0.162 0.000 -17.025
ENSG00000104880 E012 1.2470035 0.0252801510 1.504620e-02 4.059207e-02 19 7395127 7395133 7 + 0.569 0.167 -2.531
ENSG00000104880 E013 6.0243270 0.0060990425 2.784432e-02 6.770750e-02 19 7395134 7395154 21 + 0.961 0.718 -0.944
ENSG00000104880 E014 13.8983992 0.0206373706 1.665579e-04 8.204342e-04 19 7395155 7395167 13 + 1.364 0.986 -1.347
ENSG00000104880 E015 37.9166281 0.0210464117 7.290603e-02 1.481733e-01 19 7395168 7395185 18 + 1.637 1.510 -0.433
ENSG00000104880 E016 56.4102267 0.0135347901 1.734148e-02 4.569251e-02 19 7395186 7395247 62 + 1.810 1.677 -0.449
ENSG00000104880 E017 0.2214452 0.0397675548 1.000000e+00   19 7439688 7440188 501 + 0.000 0.092 14.874
ENSG00000104880 E018 17.8340145 0.0010161287 5.641501e-02 1.204475e-01 19 7440189 7440343 155 + 1.310 1.198 -0.395
ENSG00000104880 E019 100.3759628 0.0029051345 1.617582e-04 7.995022e-04 19 7440344 7440482 139 + 2.046 1.930 -0.391
ENSG00000104880 E020 86.1656609 0.0003070958 1.069010e-06 8.817133e-06 19 7441653 7441718 66 + 1.996 1.853 -0.479
ENSG00000104880 E021 79.2716683 0.0003388722 3.157868e-10 5.123746e-09 19 7441719 7441765 47 + 1.998 1.792 -0.692
ENSG00000104880 E022 0.9085219 0.9363693259 5.563948e-01 6.850459e-01 19 7441766 7441911 146 + 0.000 0.341 17.214
ENSG00000104880 E023 133.4838987 0.0031454772 7.473231e-05 4.029262e-04 19 7441912 7442052 141 + 2.160 2.051 -0.367
ENSG00000104880 E024 161.6507970 0.0047088349 1.447798e-03 5.466162e-03 19 7444204 7444454 251 + 2.226 2.143 -0.278
ENSG00000104880 E025 114.0217427 0.0005137977 4.738951e-02 1.045255e-01 19 7447043 7447168 126 + 2.034 2.011 -0.075
ENSG00000104880 E026 119.8662381 0.0105643678 1.216741e-01 2.223205e-01 19 7451149 7451266 118 + 2.071 2.029 -0.142
ENSG00000104880 E027 201.7253737 0.0011302474 1.018436e-02 2.921867e-02 19 7453467 7453715 249 + 2.284 2.257 -0.088
ENSG00000104880 E028 131.7520553 0.0002651517 2.032989e-01 3.303363e-01 19 7456327 7456403 77 + 2.075 2.082 0.024
ENSG00000104880 E029 189.8482084 0.0012863896 2.679134e-01 4.062933e-01 19 7458512 7458690 179 + 2.227 2.243 0.055
ENSG00000104880 E030 136.1040390 0.0059053297 4.447710e-01 5.863244e-01 19 7459903 7459994 92 + 2.085 2.105 0.065
ENSG00000104880 E031 181.1331167 0.0002578601 6.184859e-01 7.360960e-01 19 7462152 7462334 183 + 2.197 2.232 0.119
ENSG00000104880 E032 139.0791744 0.0003372173 3.563071e-01 5.006879e-01 19 7463818 7463955 138 + 2.093 2.112 0.064
ENSG00000104880 E033 130.2467965 0.0002870149 6.121716e-02 1.286785e-01 19 7464560 7464687 128 + 2.087 2.074 -0.043
ENSG00000104880 E034 55.4327179 0.0004486104 2.049730e-01 3.323705e-01 19 7464688 7464690 3 + 1.724 1.709 -0.051
ENSG00000104880 E035 98.4676345 0.0003158226 3.543807e-02 8.249332e-02 19 7466918 7466974 57 + 1.978 1.947 -0.103
ENSG00000104880 E036 88.5613904 0.0029290619 1.540532e-01 2.671804e-01 19 7467071 7467118 48 + 1.922 1.904 -0.062
ENSG00000104880 E037 154.4276976 0.0017911318 8.873104e-03 2.596376e-02 19 7467214 7467684 471 + 2.179 2.137 -0.141
ENSG00000104880 E038 144.9598778 0.0005177892 6.395405e-01 7.529099e-01 19 7468825 7469131 307 + 2.098 2.132 0.115
ENSG00000104880 E039 105.4975821 0.0010372745 1.227977e-02 3.420426e-02 19 7469904 7470029 126 + 1.870 2.024 0.516
ENSG00000104880 E040 134.0901181 0.0002736379 1.002826e-04 5.231654e-04 19 7470126 7470315 190 + 1.952 2.138 0.624
ENSG00000104880 E041 120.8020292 0.0017265440 1.565074e-02 4.195832e-02 19 7470316 7470536 221 + 1.934 2.085 0.506
ENSG00000104880 E042 1277.7589113 0.0076493660 1.862603e-07 1.795109e-06 19 7470537 7472793 2257 + 2.898 3.126 0.755
ENSG00000104880 E043 2.3165161 0.0099514809 8.106798e-01 8.798946e-01 19 7476911 7476986 76 + 0.448 0.524 0.374