ENSG00000104872

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262265 ENSG00000104872 HEK293_OSMI2_2hA HEK293_TMG_2hB PIH1D1 protein_coding protein_coding 127.7211 183.8111 93.22154 4.78269 1.500383 -0.9794125 61.627271 111.843576 39.973317 3.2126433 0.2900529 -1.4841413 0.46196250 0.60940000 0.42910000 -0.18030000 2.039764e-05 6.791042e-07 FALSE TRUE
ENST00000593629 ENSG00000104872 HEK293_OSMI2_2hA HEK293_TMG_2hB PIH1D1 protein_coding retained_intron 127.7211 183.8111 93.22154 4.78269 1.500383 -0.9794125 10.634223 9.362259 8.594278 0.3951981 0.8333833 -0.1233427 0.08770417 0.05093333 0.09203333 0.04110000 3.335045e-04 6.791042e-07   FALSE
ENST00000593900 ENSG00000104872 HEK293_OSMI2_2hA HEK293_TMG_2hB PIH1D1 protein_coding retained_intron 127.7211 183.8111 93.22154 4.78269 1.500383 -0.9794125 6.074583 3.475002 6.242833 0.6638253 0.3345722 0.8433507 0.05386667 0.01873333 0.06690000 0.04816667 6.791042e-07 6.791042e-07 FALSE TRUE
ENST00000595074 ENSG00000104872 HEK293_OSMI2_2hA HEK293_TMG_2hB PIH1D1 protein_coding retained_intron 127.7211 183.8111 93.22154 4.78269 1.500383 -0.9794125 9.697210 7.633278 8.215761 0.7443106 1.1929036 0.1059578 0.08287917 0.04140000 0.08783333 0.04643333 1.563901e-03 6.791042e-07 FALSE TRUE
ENST00000596895 ENSG00000104872 HEK293_OSMI2_2hA HEK293_TMG_2hB PIH1D1 protein_coding retained_intron 127.7211 183.8111 93.22154 4.78269 1.500383 -0.9794125 10.719797 10.279077 9.502225 2.2282142 0.4403412 -0.1132588 0.08945417 0.05556667 0.10186667 0.04630000 3.410722e-02 6.791042e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104872 E001 0.4438354 0.0996745381 7.872791e-01 8.637629e-01 19 49446298 49446298 1 - 0.187 0.143 -0.471
ENSG00000104872 E002 68.3024622 0.0037608644 3.466193e-03 1.162827e-02 19 49446299 49446368 70 - 1.634 1.806 0.583
ENSG00000104872 E003 154.9797916 0.0020416737 6.003251e-04 2.534312e-03 19 49446369 49446400 32 - 2.014 2.151 0.457
ENSG00000104872 E004 192.6128851 0.0019803110 6.685926e-03 2.040810e-02 19 49446401 49446423 23 - 2.140 2.237 0.326
ENSG00000104872 E005 310.2609334 0.0016740049 2.100416e-04 1.006825e-03 19 49446551 49446595 45 - 2.333 2.445 0.372
ENSG00000104872 E006 656.9155445 0.0005263997 1.180959e-05 7.717196e-05 19 49446596 49446694 99 - 2.682 2.763 0.267
ENSG00000104872 E007 29.2239368 0.0028849798 1.281104e-01 2.315321e-01 19 49446695 49446741 47 - 1.494 1.377 -0.404
ENSG00000104872 E008 18.7689489 0.0010126882 8.523965e-02 1.677947e-01 19 49446742 49446744 3 - 1.332 1.181 -0.533
ENSG00000104872 E009 30.4015727 0.0006503130 1.123473e-01 2.089706e-01 19 49446745 49446794 50 - 1.509 1.394 -0.394
ENSG00000104872 E010 12.4130808 0.0159022805 1.887727e-02 4.906423e-02 19 49446795 49446899 105 - 1.248 0.977 -0.978
ENSG00000104872 E011 695.6445774 0.0006633411 3.864471e-04 1.722374e-03 19 49447024 49447099 76 - 2.719 2.784 0.217
ENSG00000104872 E012 26.4572775 0.0035344776 1.194436e-15 4.465804e-14 19 49447100 49447177 78 - 1.726 1.146 -2.008
ENSG00000104872 E013 25.9509138 0.0007444624 8.864998e-19 4.932298e-17 19 49447214 49447286 73 - 1.731 1.127 -2.092
ENSG00000104872 E014 22.2967295 0.0059128562 4.251178e-10 6.744037e-09 19 49447287 49447337 51 - 1.617 1.109 -1.771
ENSG00000104872 E015 537.9737571 0.0001433225 5.831919e-08 6.194783e-07 19 49447338 49447374 37 - 2.582 2.679 0.322
ENSG00000104872 E016 617.3393912 0.0001073373 5.246275e-05 2.940767e-04 19 49447375 49447417 43 - 2.667 2.731 0.213
ENSG00000104872 E017 446.7065051 0.0001308689 4.564035e-03 1.472158e-02 19 49447418 49447420 3 - 2.537 2.589 0.172
ENSG00000104872 E018 458.7273656 0.0001312341 2.399561e-04 1.133159e-03 19 49447421 49447423 3 - 2.536 2.604 0.226
ENSG00000104872 E019 643.6056434 0.0001127690 6.142676e-04 2.585738e-03 19 49447424 49447467 44 - 2.695 2.747 0.174
ENSG00000104872 E020 16.9112165 0.0010552053 2.200384e-07 2.092336e-06 19 49447710 49447826 117 - 1.471 1.035 -1.539
ENSG00000104872 E021 874.0458103 0.0001332064 8.380597e-01 8.987541e-01 19 49447827 49447908 82 - 2.868 2.866 -0.007
ENSG00000104872 E022 79.2856642 0.0047377207 3.022822e-06 2.259924e-05 19 49447909 49448000 92 - 2.008 1.756 -0.846
ENSG00000104872 E023 736.4856385 0.0004081321 1.527397e-01 2.653907e-01 19 49448001 49448062 62 - 2.815 2.785 -0.098
ENSG00000104872 E024 203.5259577 0.0029948376 4.878764e-24 4.867126e-22 19 49448063 49448574 512 - 2.490 2.117 -1.248
ENSG00000104872 E025 53.0495675 0.0103858793 4.994942e-06 3.555560e-05 19 49448992 49449110 119 - 1.883 1.558 -1.101
ENSG00000104872 E026 78.1389878 0.0117593433 4.005205e-08 4.404819e-07 19 49449111 49449339 229 - 2.076 1.705 -1.249
ENSG00000104872 E027 70.1499332 0.0115890369 6.005570e-10 9.283104e-09 19 49449340 49449474 135 - 2.056 1.635 -1.418
ENSG00000104872 E028 850.6842742 0.0001180417 1.766086e-02 4.640560e-02 19 49449475 49449565 91 - 2.885 2.846 -0.128
ENSG00000104872 E029 826.5660349 0.0014907465 9.684933e-01 9.842984e-01 19 49449566 49449654 89 - 2.848 2.843 -0.019
ENSG00000104872 E030 761.3633573 0.0009486160 4.859009e-01 6.237293e-01 19 49450782 49450848 67 - 2.801 2.810 0.031
ENSG00000104872 E031 44.7705592 0.0006719810 1.153347e-04 5.924408e-04 19 49450849 49450867 19 - 1.744 1.522 -0.755
ENSG00000104872 E032 44.1724895 0.0031007336 1.202558e-04 6.151670e-04 19 49450868 49450890 23 - 1.748 1.507 -0.819
ENSG00000104872 E033 48.0814313 0.0018279897 2.184048e-04 1.042614e-03 19 49450891 49450939 49 - 1.768 1.552 -0.734
ENSG00000104872 E034 10.1678559 0.0119611574 1.564298e-03 5.843698e-03 19 49451262 49451367 106 - 1.221 0.853 -1.349
ENSG00000104872 E035 10.9358573 0.0015940095 7.811115e-07 6.640604e-06 19 49451368 49451484 117 - 1.332 0.839 -1.797
ENSG00000104872 E036 827.8269896 0.0005887789 5.172037e-01 6.516409e-01 19 49451485 49451578 94 - 2.839 2.846 0.021
ENSG00000104872 E037 519.5940171 0.0002465939 7.119926e-01 8.088416e-01 19 49451579 49451591 13 - 2.640 2.642 0.006
ENSG00000104872 E038 966.2373354 0.0006563693 4.026185e-01 5.463855e-01 19 49451592 49451901 310 - 2.926 2.907 -0.064
ENSG00000104872 E039 16.1292874 0.0309363041 4.992654e-01 6.355833e-01 19 49453270 49453375 106 - 1.221 1.134 -0.307
ENSG00000104872 E040 21.0329703 0.0011345397 3.145129e-01 4.572234e-01 19 49453376 49453392 17 - 1.332 1.244 -0.310
ENSG00000104872 E041 42.6509410 0.0005435390 6.084237e-01 7.281597e-01 19 49453393 49453497 105 - 1.543 1.570 0.092