ENSG00000104859

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221455 ENSG00000104859 HEK293_OSMI2_2hA HEK293_TMG_2hB CLASRP protein_coding protein_coding 58.4955 58.97925 47.98488 5.436336 2.211427 -0.2975715 4.531863 13.779172 0.6637629 0.7764428 0.6637629 -4.3551510 0.07791667 0.23573333 0.01480000 -0.220933333 0.020887572 0.0004080768 FALSE TRUE
ENST00000391952 ENSG00000104859 HEK293_OSMI2_2hA HEK293_TMG_2hB CLASRP protein_coding nonsense_mediated_decay 58.4955 58.97925 47.98488 5.436336 2.211427 -0.2975715 7.603835 9.197697 6.4841898 0.5168569 0.4920942 -0.5036908 0.13059167 0.15743333 0.13480000 -0.022633333 0.461481731 0.0004080768 TRUE TRUE
ENST00000585432 ENSG00000104859 HEK293_OSMI2_2hA HEK293_TMG_2hB CLASRP protein_coding retained_intron 58.4955 58.97925 47.98488 5.436336 2.211427 -0.2975715 8.128967 6.389659 5.9254053 0.3131319 0.7780491 -0.1086485 0.13656250 0.10946667 0.12436667 0.014900000 0.829090507 0.0004080768   FALSE
ENST00000585615 ENSG00000104859 HEK293_OSMI2_2hA HEK293_TMG_2hB CLASRP protein_coding retained_intron 58.4955 58.97925 47.98488 5.436336 2.211427 -0.2975715 4.502249 3.712967 3.3088701 0.5975558 0.5687548 -0.1657607 0.07464167 0.06220000 0.06823333 0.006033333 0.873429988 0.0004080768 FALSE FALSE
ENST00000587112 ENSG00000104859 HEK293_OSMI2_2hA HEK293_TMG_2hB CLASRP protein_coding nonsense_mediated_decay 58.4955 58.97925 47.98488 5.436336 2.211427 -0.2975715 9.509396 6.482982 9.3817723 1.1710431 0.2141609 0.5325163 0.16606250 0.10850000 0.19590000 0.087400000 0.002358161 0.0004080768 TRUE FALSE
MSTRG.17304.3 ENSG00000104859 HEK293_OSMI2_2hA HEK293_TMG_2hB CLASRP protein_coding   58.4955 58.97925 47.98488 5.436336 2.211427 -0.2975715 7.850567 5.635482 7.5712229 0.8920632 0.4153233 0.4253339 0.13487917 0.09496667 0.15863333 0.063666667 0.016308732 0.0004080768 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104859 E001 0.2214452 0.0372567942 7.981888e-01   19 45039045 45039045 1 + 0.000 0.097 9.298
ENSG00000104859 E002 0.2214452 0.0372567942 7.981888e-01   19 45039046 45039049 4 + 0.000 0.097 9.301
ENSG00000104859 E003 0.2214452 0.0372567942 7.981888e-01   19 45039050 45039050 1 + 0.000 0.097 9.301
ENSG00000104859 E004 0.5944058 0.2502588585 9.652500e-01 9.821297e-01 19 45039051 45039052 2 + 0.154 0.180 0.267
ENSG00000104859 E005 0.5944058 0.2502588585 9.652500e-01 9.821297e-01 19 45039053 45039053 1 + 0.154 0.180 0.267
ENSG00000104859 E006 1.3641733 0.1757111273 7.421117e-01 8.311110e-01 19 45039054 45039060 7 + 0.268 0.361 0.606
ENSG00000104859 E007 8.8078170 0.0034512783 9.391393e-01 9.657756e-01 19 45039061 45039064 4 + 0.959 0.953 -0.022
ENSG00000104859 E008 36.8003875 0.0057203643 2.320696e-01 3.648976e-01 19 45039065 45039073 9 + 1.595 1.515 -0.271
ENSG00000104859 E009 78.6928659 0.0003756243 1.135111e-02 3.200478e-02 19 45039074 45039108 35 + 1.933 1.832 -0.341
ENSG00000104859 E010 0.5943067 0.0212616167 1.243582e-01 2.262054e-01 19 45039521 45039917 397 + 0.358 0.096 -2.363
ENSG00000104859 E011 1.5770011 0.0132280511 1.438094e-01 2.531909e-01 19 45039918 45040183 266 + 0.551 0.300 -1.362
ENSG00000104859 E012 143.5169237 0.0010368876 3.171621e-05 1.876027e-04 19 45040184 45040269 86 + 2.213 2.077 -0.454
ENSG00000104859 E013 158.4960690 0.0011716516 4.601377e-03 1.482436e-02 19 45040270 45040311 42 + 2.229 2.139 -0.300
ENSG00000104859 E014 3.2461929 0.0049932289 6.346981e-01 7.491085e-01 19 45040312 45040747 436 + 0.644 0.573 -0.316
ENSG00000104859 E015 152.2181201 0.0002389542 1.536207e-03 5.753965e-03 19 45052071 45052097 27 + 2.213 2.122 -0.305
ENSG00000104859 E016 190.8415703 0.0002445371 1.808136e-04 8.814644e-04 19 45052098 45052168 71 + 2.313 2.216 -0.324
ENSG00000104859 E017 132.1398727 0.0004827000 2.081458e-01 3.362446e-01 19 45052791 45052799 9 + 2.114 2.076 -0.128
ENSG00000104859 E018 250.6142404 0.0001761803 2.372461e-05 1.446637e-04 19 45052800 45052892 93 + 2.429 2.334 -0.316
ENSG00000104859 E019 17.0471085 0.0173505241 9.861653e-13 2.423794e-11 19 45052893 45053097 205 + 1.576 0.829 -2.675
ENSG00000104859 E020 128.6053147 0.0002379034 1.458136e-07 1.435234e-06 19 45053098 45053110 13 + 2.184 2.019 -0.551
ENSG00000104859 E021 261.5990866 0.0003362698 3.185699e-09 4.301647e-08 19 45053111 45053177 67 + 2.473 2.339 -0.449
ENSG00000104859 E022 313.8320875 0.0002448467 2.325558e-07 2.202079e-06 19 45056450 45056534 85 + 2.535 2.429 -0.352
ENSG00000104859 E023 415.5587720 0.0014822175 2.937752e-01 4.348237e-01 19 45057750 45057882 133 + 2.603 2.583 -0.066
ENSG00000104859 E024 175.3122406 0.0002296006 2.921482e-01 4.330914e-01 19 45057883 45057898 16 + 2.191 2.225 0.113
ENSG00000104859 E025 4.3306235 0.0035673203 1.880682e-03 6.854979e-03 19 45057899 45058253 355 + 0.938 0.510 -1.776
ENSG00000104859 E026 332.7646996 0.0001807726 4.371483e-01 5.791631e-01 19 45059268 45059364 97 + 2.500 2.488 -0.041
ENSG00000104859 E027 298.5523795 0.0007254224 1.701583e-01 2.883903e-01 19 45060389 45060467 79 + 2.465 2.437 -0.095
ENSG00000104859 E028 254.3544695 0.0008964974 1.008046e-01 1.916863e-01 19 45060554 45060627 74 + 2.403 2.364 -0.128
ENSG00000104859 E029 160.6490916 0.0004435500 5.889543e-01 7.120903e-01 19 45062154 45062195 42 + 2.165 2.185 0.068
ENSG00000104859 E030 244.1236335 0.0001905983 5.141384e-03 1.631360e-02 19 45064012 45064227 216 + 2.306 2.379 0.242
ENSG00000104859 E031 34.6970282 0.0009077535 3.317761e-05 1.951926e-04 19 45064228 45064342 115 + 1.668 1.421 -0.844
ENSG00000104859 E032 221.5036652 0.0049111974 2.258264e-02 5.688470e-02 19 45064343 45064630 288 + 2.242 2.347 0.348
ENSG00000104859 E033 169.9347256 0.0093015516 1.739667e-01 2.933385e-01 19 45067337 45067470 134 + 2.142 2.227 0.284
ENSG00000104859 E034 228.0259517 0.0017742528 1.775864e-04 8.678985e-04 19 45067471 45067594 124 + 2.238 2.364 0.420
ENSG00000104859 E035 175.2744307 0.0003159783 1.997929e-13 5.442936e-12 19 45068015 45068054 40 + 2.047 2.276 0.769
ENSG00000104859 E036 47.6942450 0.0005023739 4.797142e-01 6.180457e-01 19 45068055 45068058 4 + 1.626 1.668 0.140
ENSG00000104859 E037 22.5486508 0.0008755288 1.363400e-03 5.187735e-03 19 45068059 45068120 62 + 1.483 1.253 -0.797
ENSG00000104859 E038 14.9002774 0.0013081683 2.511176e-01 3.872769e-01 19 45068121 45068180 60 + 1.235 1.136 -0.351
ENSG00000104859 E039 27.8225129 0.0007111692 4.454230e-03 1.441305e-02 19 45068202 45068419 218 + 1.545 1.360 -0.639
ENSG00000104859 E040 212.7686627 0.0003737275 4.053470e-08 4.452472e-07 19 45068420 45068480 61 + 2.187 2.343 0.519
ENSG00000104859 E041 182.0291627 0.0001965652 7.246454e-04 2.987572e-03 19 45069066 45069082 17 + 2.160 2.260 0.334
ENSG00000104859 E042 240.0016010 0.0002046258 1.317298e-06 1.066032e-05 19 45069083 45069124 42 + 2.263 2.388 0.418
ENSG00000104859 E043 15.6548449 0.0014548823 1.910207e-01 3.150316e-01 19 45069125 45069201 77 + 1.256 1.144 -0.396
ENSG00000104859 E044 248.3141344 0.0002268651 1.573728e-10 2.684411e-09 19 45069202 45069248 47 + 2.249 2.413 0.549
ENSG00000104859 E045 34.4564978 0.0006227381 1.600386e-09 2.284938e-08 19 45069646 45069838 193 + 1.720 1.364 -1.219
ENSG00000104859 E046 21.4707633 0.0009173694 1.739350e-06 1.371149e-05 19 45069839 45069943 105 + 1.523 1.174 -1.217
ENSG00000104859 E047 23.6454623 0.0419937519 4.185445e-02 9.445597e-02 19 45069944 45070021 78 + 1.501 1.277 -0.778
ENSG00000104859 E048 305.2458829 0.0012877210 3.349497e-06 2.482113e-05 19 45070022 45070104 83 + 2.363 2.496 0.444
ENSG00000104859 E049 195.1243435 0.0017877645 6.018117e-06 4.207995e-05 19 45070537 45070561 25 + 2.150 2.310 0.536
ENSG00000104859 E050 20.4332474 0.0013900463 5.530569e-01 6.822729e-01 19 45070562 45070802 241 + 1.331 1.288 -0.151
ENSG00000104859 E051 168.1661161 0.0021752020 1.270266e-04 6.457577e-04 19 45070803 45070956 154 + 2.095 2.243 0.494