ENSG00000104852

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221448 ENSG00000104852 HEK293_OSMI2_2hA HEK293_TMG_2hB SNRNP70 protein_coding protein_coding 447.238 757.5364 227.1534 29.65107 2.189058 -1.737604 118.0284 205.4282 63.33877 8.346547 3.411022 -1.697316 0.2639292 0.2711667 0.2791667 0.0080 9.226526e-01 8.031263e-50 FALSE TRUE
ENST00000598441 ENSG00000104852 HEK293_OSMI2_2hA HEK293_TMG_2hB SNRNP70 protein_coding protein_coding 447.238 757.5364 227.1534 29.65107 2.189058 -1.737604 263.6951 486.0537 108.60066 15.982570 3.948383 -2.161980 0.5607167 0.6420000 0.4779000 -0.1641 6.826632e-11 8.031263e-50 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104852 E001 19.941523 1.071802e-02 8.064860e-02 1.605674e-01 19 49085275 49085320 46 + 1.024 1.232 0.748
ENSG00000104852 E002 39.641014 1.042608e-03 1.219866e-02 3.400729e-02 19 49085321 49085418 98 + 1.317 1.516 0.686
ENSG00000104852 E003 30.583795 1.741302e-03 4.975161e-02 1.087191e-01 19 49085419 49085422 4 + 1.229 1.403 0.609
ENSG00000104852 E004 85.746111 6.292378e-03 2.855147e-02 6.911761e-02 19 49085423 49085450 28 + 1.694 1.840 0.495
ENSG00000104852 E005 1222.457489 4.336271e-03 6.264365e-01 7.423871e-01 19 49085451 49085494 44 + 2.979 2.968 -0.035
ENSG00000104852 E006 2830.964290 1.512698e-03 5.520586e-01 6.814342e-01 19 49085495 49085636 142 + 3.340 3.333 -0.021
ENSG00000104852 E007 2.243349 6.881228e-03 6.343114e-01 7.488014e-01 19 49085637 49085703 67 + 0.357 0.451 0.519
ENSG00000104852 E008 1.356698 1.542650e-01 7.023844e-01 8.012176e-01 19 49085704 49085723 20 + 0.214 0.307 0.689
ENSG00000104852 E009 1.538402 2.118554e-01 6.223998e-01 7.392171e-01 19 49085724 49085725 2 + 0.214 0.344 0.922
ENSG00000104852 E010 15.004036 1.161450e-03 9.388882e-01 9.656328e-01 19 49085726 49085849 124 + 1.096 1.090 -0.022
ENSG00000104852 E011 2942.801579 3.048451e-04 4.854787e-02 1.065915e-01 19 49086405 49086479 75 + 3.365 3.347 -0.062
ENSG00000104852 E012 2949.617684 6.174842e-05 8.571756e-15 2.849436e-13 19 49086480 49086523 44 + 3.403 3.339 -0.212
ENSG00000104852 E013 2719.161490 6.517191e-05 2.233000e-15 8.060882e-14 19 49086524 49086561 38 + 3.371 3.303 -0.226
ENSG00000104852 E014 5.011342 3.331369e-03 1.648703e-03 6.116795e-03 19 49087634 49087777 144 + 0.997 0.563 -1.747
ENSG00000104852 E015 3408.902946 4.851010e-05 2.446657e-15 8.798629e-14 19 49090291 49090353 63 + 3.462 3.403 -0.198
ENSG00000104852 E016 3767.218285 4.272730e-05 1.278940e-10 2.217567e-09 19 49090466 49090520 55 + 3.494 3.449 -0.151
ENSG00000104852 E017 8.832579 2.466655e-03 2.098554e-01 3.383789e-01 19 49090521 49090639 119 + 0.737 0.919 0.712
ENSG00000104852 E018 3977.534917 1.298122e-04 2.937324e-02 7.072269e-02 19 49098427 49098491 65 + 3.494 3.479 -0.050
ENSG00000104852 E019 3970.895610 2.542912e-04 6.196579e-01 7.369937e-01 19 49098642 49098704 63 + 3.474 3.483 0.031
ENSG00000104852 E020 4482.090475 5.822203e-04 7.619715e-02 1.534269e-01 19 49101390 49101471 82 + 3.511 3.539 0.093
ENSG00000104852 E021 52.464963 1.429981e-02 2.115694e-15 7.659314e-14 19 49101472 49101668 197 + 2.021 1.425 -2.021
ENSG00000104852 E022 108.967300 5.985702e-03 2.343972e-25 2.647933e-23 19 49102114 49102173 60 + 2.299 1.771 -1.773
ENSG00000104852 E023 55.932653 1.262395e-02 2.519808e-20 1.670294e-18 19 49102174 49102185 12 + 2.083 1.421 -2.242
ENSG00000104852 E024 186.918064 8.311929e-03 1.385697e-37 4.095416e-35 19 49102186 49102410 225 + 2.603 1.940 -2.214
ENSG00000104852 E025 820.484823 3.655011e-03 5.903095e-76 1.075311e-72 19 49102411 49103587 1177 + 3.206 2.617 -1.956
ENSG00000104852 E026 69.799597 1.211970e-03 3.788832e-18 1.941528e-16 19 49103588 49103665 78 + 2.036 1.626 -1.385
ENSG00000104852 E027 99.092832 7.661622e-04 1.652578e-57 1.534686e-54 19 49103666 49103842 177 + 2.302 1.692 -2.049
ENSG00000104852 E028 48.210884 8.167540e-03 2.738332e-18 1.427542e-16 19 49103843 49103918 76 + 1.979 1.399 -1.973
ENSG00000104852 E029 566.638233 5.652854e-03 5.019790e-37 1.427904e-34 19 49103919 49104633 715 + 2.997 2.494 -1.674
ENSG00000104852 E030 5045.660729 4.250960e-04 5.732675e-09 7.405647e-08 19 49104634 49104735 102 + 3.527 3.597 0.236
ENSG00000104852 E031 2463.580474 1.028263e-03 2.134036e-08 2.475275e-07 19 49107625 49107627 3 + 3.185 3.292 0.353
ENSG00000104852 E032 4504.344027 1.041139e-04 1.164242e-60 1.198707e-57 19 49107628 49107712 85 + 3.415 3.557 0.473
ENSG00000104852 E033 1999.788479 5.860465e-04 4.266277e-35 1.048292e-32 19 49107795 49107821 27 + 3.008 3.213 0.682
ENSG00000104852 E034 9408.977533 2.793327e-04 6.540392e-45 3.036906e-42 19 49107822 49108605 784 + 3.752 3.876 0.412