ENSG00000104833

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264071 ENSG00000104833 HEK293_OSMI2_2hA HEK293_TMG_2hB TUBB4A protein_coding protein_coding 20.73686 35.30166 13.35164 3.225629 0.4248988 -1.402047 17.696786 32.491484 10.184454 2.6434016 0.3450995 -1.6727211 0.8407750 0.9223333 0.7627667 -0.1595667 3.472194e-07 3.472194e-07 FALSE TRUE
ENST00000598635 ENSG00000104833 HEK293_OSMI2_2hA HEK293_TMG_2hB TUBB4A protein_coding protein_coding 20.73686 35.30166 13.35164 3.225629 0.4248988 -1.402047 2.060182 1.875578 2.861429 0.4362871 0.1405379 0.6067618 0.1011333 0.0533000 0.2149333 0.1616333 7.925445e-07 3.472194e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104833 E001 948.9837050 0.0048324038 2.262705e-06 1.739398e-05 19 6494319 6495721 1403 - 2.765 2.933 0.556
ENSG00000104833 E002 157.5556685 0.0002937221 8.770758e-01 9.250657e-01 19 6495722 6495806 85 - 2.093 2.124 0.102
ENSG00000104833 E003 88.7555863 0.0003555158 8.457915e-01 9.040945e-01 19 6495807 6495807 1 - 1.844 1.878 0.113
ENSG00000104833 E004 166.9844423 0.0002405557 8.912367e-01 9.345280e-01 19 6495808 6495904 97 - 2.119 2.149 0.099
ENSG00000104833 E005 125.9551751 0.0002552145 7.231908e-01 8.170751e-01 19 6495905 6495958 54 - 1.992 2.030 0.127
ENSG00000104833 E006 123.5376096 0.0002704227 4.056960e-01 5.493460e-01 19 6495959 6496015 57 - 1.970 2.026 0.189
ENSG00000104833 E007 95.1568827 0.0003414340 3.288082e-01 4.722971e-01 19 6496016 6496027 12 - 1.851 1.918 0.226
ENSG00000104833 E008 98.9581793 0.0003382072 4.295257e-01 5.722468e-01 19 6496028 6496060 33 - 1.874 1.932 0.196
ENSG00000104833 E009 124.8815119 0.0002416461 6.917061e-01 7.931391e-01 19 6496061 6496129 69 - 1.988 2.027 0.133
ENSG00000104833 E010 71.8182143 0.0003982966 5.306535e-01 6.632224e-01 19 6496130 6496130 1 - 1.786 1.781 -0.019
ENSG00000104833 E011 84.0438683 0.0004341800 8.309995e-01 8.940516e-01 19 6496131 6496141 11 - 1.837 1.853 0.051
ENSG00000104833 E012 104.0631622 0.0005619901 8.193936e-01 8.859597e-01 19 6496142 6496169 28 - 1.930 1.946 0.052
ENSG00000104833 E013 94.0107588 0.0006212380 9.393887e-01 9.659325e-01 19 6496170 6496174 5 - 1.880 1.902 0.073
ENSG00000104833 E014 91.2789888 0.0003465172 7.808905e-01 8.592322e-01 19 6496175 6496175 1 - 1.874 1.887 0.043
ENSG00000104833 E015 96.6807035 0.0003399524 7.710252e-01 8.521855e-01 19 6496176 6496178 3 - 1.898 1.911 0.042
ENSG00000104833 E016 136.7344117 0.0002647032 3.995639e-02 9.095693e-02 19 6496179 6496221 43 - 2.093 2.047 -0.154
ENSG00000104833 E017 0.0000000       19 6496370 6496463 94 -      
ENSG00000104833 E018 0.1515154 0.0435758535 1.556778e-01   19 6500616 6500742 127 - 0.189 0.000 -16.360
ENSG00000104833 E019 0.6245948 0.0341737360 4.279680e-01 5.707796e-01 19 6500928 6501286 359 - 0.000 0.200 14.692
ENSG00000104833 E020 160.9855158 0.0002354270 2.144029e-02 5.451490e-02 19 6501287 6501397 111 - 2.165 2.118 -0.160
ENSG00000104833 E021 78.3427562 0.0003433807 8.784095e-02 1.718436e-01 19 6501515 6501521 7 - 1.858 1.805 -0.177
ENSG00000104833 E022 116.7315413 0.0003028442 4.862167e-02 1.067190e-01 19 6501522 6501580 59 - 2.025 1.976 -0.163
ENSG00000104833 E023 91.7177356 0.0008926978 1.602304e-03 5.968729e-03 19 6501581 6501614 34 - 1.968 1.859 -0.366
ENSG00000104833 E024 73.6612289 0.0080821452 7.209921e-03 2.177055e-02 19 6501615 6501623 9 - 1.896 1.760 -0.456
ENSG00000104833 E025 0.4417591 0.1856790988 7.356186e-01 8.263457e-01 19 6501624 6501787 164 - 0.189 0.140 -0.523
ENSG00000104833 E026 88.7413962 0.0055801598 2.955881e-04 1.361892e-03 19 6502156 6502188 33 - 1.992 1.830 -0.547
ENSG00000104833 E027 93.7850614 0.0074588655 6.796952e-04 2.824874e-03 19 6502189 6502262 74 - 2.014 1.854 -0.536
ENSG00000104833 E028 58.0413008 0.0077558727 5.452206e-04 2.329036e-03 19 6502263 6502314 52 - 1.830 1.639 -0.648
ENSG00000104833 E029 14.6182413 0.0015237192 3.395398e-05 1.992797e-04 19 6502315 6502332 18 - 1.359 1.005 -1.262
ENSG00000104833 E030 1.5771134 0.0122036792 2.151819e-01 3.446451e-01 19 6502333 6502338 6 - 0.503 0.295 -1.171
ENSG00000104833 E031 0.6621601 0.0165218661 2.899161e-01 4.306731e-01 19 6502679 6502848 170 - 0.321 0.142 -1.495