ENSG00000104825

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313582 ENSG00000104825 HEK293_OSMI2_2hA HEK293_TMG_2hB NFKBIB protein_coding protein_coding 38.87308 64.9951 26.06254 3.380498 1.056158 -1.318022 20.106799 33.87721 13.958983 1.6803431 0.6822315 -1.2785140 0.5059500 0.5214 0.5363333 0.01493333 0.880640791 0.005336614 FALSE TRUE
ENST00000509705 ENSG00000104825 HEK293_OSMI2_2hA HEK293_TMG_2hB NFKBIB protein_coding nonsense_mediated_decay 38.87308 64.9951 26.06254 3.380498 1.056158 -1.318022 9.535120 18.59189 4.754899 0.7808934 0.1823167 -1.9649318 0.2348958 0.2883 0.1825000 -0.10580000 0.005336614 0.005336614 FALSE TRUE
ENST00000572515 ENSG00000104825 HEK293_OSMI2_2hA HEK293_TMG_2hB NFKBIB protein_coding protein_coding 38.87308 64.9951 26.06254 3.380498 1.056158 -1.318022 8.173293 10.75745 6.212021 1.6897504 0.5685568 -0.7912212 0.2306792 0.1638 0.2378667 0.07406667 0.150701561 0.005336614 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104825 E001 1.2543759 0.3857889264 5.772644e-01 0.7025407638 19 38899700 38899739 40 + 0.421 0.258 -1.015
ENSG00000104825 E002 0.3634088 0.3832528815 7.814499e-01   19 38899935 38899951 17 + 0.000 0.143 8.512
ENSG00000104825 E003 1.0966446 0.1757943002 7.595349e-01 0.8438845755 19 38899952 38899965 14 + 0.320 0.254 -0.454
ENSG00000104825 E004 3.0381091 0.1053000207 4.621141e-01 0.6020143342 19 38899966 38899968 3 + 0.421 0.575 0.753
ENSG00000104825 E005 5.0999195 0.0582620244 2.759330e-01 0.4153365519 19 38899969 38899977 9 + 0.845 0.660 -0.749
ENSG00000104825 E006 5.6513623 0.0454720139 4.107169e-01 0.5543141593 19 38899978 38899979 2 + 0.845 0.712 -0.532
ENSG00000104825 E007 10.4753072 0.0019859880 9.946456e-01 1.0000000000 19 38899980 38899985 6 + 0.988 0.988 0.000
ENSG00000104825 E008 164.9784963 0.0018813980 3.706192e-01 0.5150276723 19 38899986 38900079 94 + 2.163 2.132 -0.105
ENSG00000104825 E009 341.3248407 0.0001972364 3.862967e-04 0.0017218065 19 38900080 38900211 132 + 2.511 2.436 -0.249
ENSG00000104825 E010 253.3951291 0.0022749644 5.355705e-05 0.0002995372 19 38905015 38905070 56 + 2.421 2.294 -0.425
ENSG00000104825 E011 282.0807077 0.0030541475 7.689397e-04 0.0031464278 19 38905071 38905120 50 + 2.455 2.345 -0.367
ENSG00000104825 E012 166.1312633 0.0008225324 8.247075e-03 0.0244103359 19 38905202 38905205 4 + 2.207 2.121 -0.285
ENSG00000104825 E013 579.9210373 0.0003996066 5.966101e-01 0.7185222314 19 38905206 38905535 330 + 2.690 2.682 -0.025
ENSG00000104825 E014 339.6444211 0.0001969244 1.067730e-03 0.0041932501 19 38907221 38907309 89 + 2.394 2.470 0.252
ENSG00000104825 E015 642.0050416 0.0001991884 1.192914e-02 0.0333632732 19 38907399 38907659 261 + 2.697 2.739 0.140
ENSG00000104825 E016 735.7073745 0.0015009775 1.635583e-03 0.0060751384 19 38907660 38908730 1071 + 2.735 2.805 0.232
ENSG00000104825 E017 224.8535739 0.0043159238 1.421346e-03 0.0053775416 19 38908731 38908893 163 + 2.167 2.306 0.465