ENSG00000104812

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323798 ENSG00000104812 HEK293_OSMI2_2hA HEK293_TMG_2hB GYS1 protein_coding protein_coding 57.43436 88.78798 40.51333 5.769532 0.7542137 -1.131774 47.537602 77.007019 32.317785 5.3844805 0.6801725 -1.2524026 0.81222500 0.86676667 0.79860000 -0.06816667 1.810953e-01 2.461954e-35 FALSE  
ENST00000484289 ENSG00000104812 HEK293_OSMI2_2hA HEK293_TMG_2hB GYS1 protein_coding retained_intron 57.43436 88.78798 40.51333 5.769532 0.7542137 -1.131774 3.258584 2.134023 3.205516 0.6946793 1.0734390 0.5847304 0.06572083 0.02396667 0.07856667 0.05460000 9.700874e-02 2.461954e-35 FALSE  
ENST00000496048 ENSG00000104812 HEK293_OSMI2_2hA HEK293_TMG_2hB GYS1 protein_coding retained_intron 57.43436 88.78798 40.51333 5.769532 0.7542137 -1.131774 1.319960 0.000000 2.205444 0.0000000 0.2387544 7.7914519 0.02887083 0.00000000 0.05426667 0.05426667 2.461954e-35 2.461954e-35 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104812 E001 0.7813216 0.0614458385 5.312953e-01 6.637758e-01 19 48967996 48968123 128 - 0.312 0.204 -0.809
ENSG00000104812 E002 2.9128979 0.0583307239 9.000206e-01 9.402051e-01 19 48968124 48968129 6 - 0.560 0.554 -0.025
ENSG00000104812 E003 934.9441883 0.0053746248 4.936159e-09 6.449689e-08 19 48968130 48968437 308 - 2.706 2.951 0.813
ENSG00000104812 E004 1641.5319129 0.0028495380 2.236541e-12 5.185485e-11 19 48968438 48969015 578 - 2.983 3.189 0.682
ENSG00000104812 E005 1210.8751894 0.0006298563 2.713034e-07 2.532027e-06 19 48969016 48969611 596 - 2.928 3.036 0.361
ENSG00000104812 E006 399.5625257 0.0010886172 1.445311e-02 3.925251e-02 19 48969775 48969855 81 - 2.463 2.551 0.293
ENSG00000104812 E007 5.1166522 0.0160888455 4.493058e-02 1.000725e-01 19 48970283 48970545 263 - 0.411 0.782 1.682
ENSG00000104812 E008 573.9857952 0.0009859198 8.715937e-03 2.557752e-02 19 48970546 48970709 164 - 2.623 2.707 0.280
ENSG00000104812 E009 9.4846899 0.0072740365 2.563749e-01 3.933263e-01 19 48970750 48970927 178 - 1.041 0.927 -0.422
ENSG00000104812 E010 292.8773729 0.0001878835 2.769480e-01 4.164508e-01 19 48970928 48970943 16 - 2.398 2.394 -0.014
ENSG00000104812 E011 416.8136948 0.0009588130 4.108930e-01 5.544762e-01 19 48970944 48971023 80 - 2.545 2.550 0.014
ENSG00000104812 E012 529.7903990 0.0001171913 3.975145e-02 9.056224e-02 19 48974213 48974339 127 - 2.664 2.649 -0.048
ENSG00000104812 E013 488.4195799 0.0001620332 8.350875e-01 8.967857e-01 19 48974620 48974733 114 - 2.599 2.625 0.087
ENSG00000104812 E014 398.6291588 0.0005740411 6.784620e-01 7.829237e-01 19 48977924 48978002 79 - 2.507 2.540 0.108
ENSG00000104812 E015 408.9387950 0.0007295085 2.470801e-02 6.127821e-02 19 48978098 48978157 60 - 2.564 2.535 -0.097
ENSG00000104812 E016 16.3894025 0.0010829632 6.921088e-04 2.870358e-03 19 48978158 48978307 150 - 1.363 1.089 -0.968
ENSG00000104812 E017 11.8041149 0.0589836930 7.588404e-02 1.529199e-01 19 48981431 48981529 99 - 1.212 0.964 -0.898
ENSG00000104812 E018 526.7412520 0.0005928889 1.022110e-05 6.779489e-05 19 48981530 48981636 107 - 2.700 2.634 -0.220
ENSG00000104812 E019 495.7141930 0.0007641455 5.825441e-06 4.085486e-05 19 48982255 48982375 121 - 2.679 2.605 -0.247
ENSG00000104812 E020 439.5472155 0.0024045663 1.188414e-03 4.602239e-03 19 48982720 48982837 118 - 2.627 2.556 -0.236
ENSG00000104812 E021 511.2649541 0.0006129944 6.513482e-11 1.184563e-09 19 48985461 48985605 145 - 2.719 2.610 -0.365
ENSG00000104812 E022 468.6932088 0.0029523201 8.351765e-06 5.648757e-05 19 48985850 48986035 186 - 2.684 2.572 -0.373
ENSG00000104812 E023 446.9360200 0.0032938732 3.623895e-04 1.628290e-03 19 48987194 48987385 192 - 2.649 2.558 -0.303
ENSG00000104812 E024 507.0697472 0.0017378135 7.273399e-10 1.106855e-08 19 48991302 48991483 182 - 2.733 2.599 -0.444
ENSG00000104812 E025 9.1888561 0.0022543095 2.533385e-01 3.898451e-01 19 48991484 48991538 55 - 1.020 0.906 -0.423
ENSG00000104812 E026 553.0016794 0.0028306121 2.916036e-08 3.289670e-07 19 48992995 48993327 333 - 2.773 2.636 -0.456
ENSG00000104812 E027 0.1451727 0.0426600708 1.728175e-01   19 49002667 49002736 70 - 0.183 0.000 -10.024