ENSG00000104714

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262109 ENSG00000104714 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH1 protein_coding protein_coding 14.15984 16.52603 13.68537 0.3694451 0.3265415 -0.2719249 7.4118159 7.4882725 7.9505338 0.3330746 0.29038292 0.08630692 0.52311667 0.45376667 0.58213333 0.128366667 7.597496e-02 3.324416e-24 FALSE TRUE
ENST00000518895 ENSG00000104714 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH1 protein_coding processed_transcript 14.15984 16.52603 13.68537 0.3694451 0.3265415 -0.2719249 0.8349538 0.5009165 0.8527444 0.1153061 0.17891865 0.75584556 0.05992083 0.03060000 0.06293333 0.032333333 2.572021e-01 3.324416e-24 FALSE FALSE
ENST00000523053 ENSG00000104714 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH1 protein_coding retained_intron 14.15984 16.52603 13.68537 0.3694451 0.3265415 -0.2719249 0.7200080 0.4653537 0.6221352 0.1251781 0.09700444 0.41123159 0.05266250 0.02783333 0.04520000 0.017366667 4.218315e-01 3.324416e-24   FALSE
ENST00000523709 ENSG00000104714 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH1 protein_coding processed_transcript 14.15984 16.52603 13.68537 0.3694451 0.3265415 -0.2719249 0.7688430 0.9014206 0.8072699 0.2099796 0.23233159 -0.15730437 0.05559583 0.05433333 0.05836667 0.004033333 9.934497e-01 3.324416e-24   FALSE
MSTRG.31028.10 ENSG00000104714 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH1 protein_coding   14.15984 16.52603 13.68537 0.3694451 0.3265415 -0.2719249 0.9227070 0.7384168 1.2095542 0.1760958 0.13825948 0.70443997 0.06510417 0.04430000 0.08896667 0.044666667 1.015890e-01 3.324416e-24 FALSE TRUE
MSTRG.31028.14 ENSG00000104714 HEK293_OSMI2_2hA HEK293_TMG_2hB ERICH1 protein_coding   14.15984 16.52603 13.68537 0.3694451 0.3265415 -0.2719249 2.3074390 5.3418514 0.7209218 0.1156384 0.13207500 -2.87224909 0.15797917 0.32326667 0.05240000 -0.270866667 3.324416e-24 3.324416e-24 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104714 E001 0.2998086 0.0291408979 9.107631e-01   8 614746 614748 3 - 0.130 0.115 -0.194
ENSG00000104714 E002 10.1604609 0.0058590807 5.465663e-01 6.767272e-01 8 614749 615284 536 - 1.084 1.030 -0.196
ENSG00000104714 E003 5.6601380 0.0285147129 6.861511e-01 7.887363e-01 8 615285 616525 1241 - 0.840 0.792 -0.187
ENSG00000104714 E004 0.4417471 0.6252260326 2.427749e-01 3.774402e-01 8 616526 616581 56 - 0.310 0.000 -11.038
ENSG00000104714 E005 3.9783225 0.0047215368 3.952665e-01 5.390843e-01 8 625675 625968 294 - 0.616 0.746 0.545
ENSG00000104714 E006 1.1081987 0.0162909431 8.622169e-01 9.151562e-01 8 625969 627002 1034 - 0.310 0.346 0.222
ENSG00000104714 E007 1.3620124 0.1090030521 2.861701e-01 4.265700e-01 8 627003 627238 236 - 0.489 0.280 -1.205
ENSG00000104714 E008 7.1764892 0.1026626863 4.669281e-01 6.064466e-01 8 637536 637595 60 - 0.793 0.954 0.619
ENSG00000104714 E009 6.7901886 0.0522841363 9.131745e-02 1.771869e-01 8 640583 640657 75 - 0.684 0.973 1.133
ENSG00000104714 E010 10.4386138 0.0399912580 1.313249e-01 2.359917e-01 8 640658 640834 177 - 0.901 1.119 0.804
ENSG00000104714 E011 4.6531430 0.0035296191 9.844860e-01 9.943748e-01 8 641114 641207 94 - 0.742 0.746 0.016
ENSG00000104714 E012 92.4040800 0.0318777885 5.151278e-01 6.498336e-01 8 664200 664621 422 - 1.929 1.992 0.212
ENSG00000104714 E013 52.9498371 0.0068695271 4.245540e-01 5.675109e-01 8 664622 664676 55 - 1.696 1.755 0.198
ENSG00000104714 E014 20.8078447 0.0008919542 1.212448e-01 2.217001e-01 8 665992 668597 2606 - 1.392 1.285 -0.372
ENSG00000104714 E015 73.3931167 0.0003585605 4.223057e-01 5.654471e-01 8 668598 668792 195 - 1.842 1.882 0.135
ENSG00000104714 E016 3.5845834 0.0562366389 5.252641e-01 6.586601e-01 8 668793 669277 485 - 0.578 0.697 0.516
ENSG00000104714 E017 7.4955731 0.0588839037 2.977503e-01 4.390984e-01 8 671794 672204 411 - 1.002 0.839 -0.618
ENSG00000104714 E018 80.1324983 0.0003762325 8.873996e-01 9.320316e-01 8 673289 673483 195 - 1.897 1.911 0.046
ENSG00000104714 E019 129.9581644 0.0004049675 4.212298e-02 9.494845e-02 8 673484 673766 283 - 2.143 2.091 -0.174
ENSG00000104714 E020 57.5536462 0.0008987519 2.999871e-02 7.195610e-02 8 673767 673843 77 - 1.813 1.720 -0.314
ENSG00000104714 E021 37.8783631 0.0060556692 1.455424e-01 2.556090e-01 8 673844 673864 21 - 1.631 1.540 -0.310
ENSG00000104714 E022 76.8632410 0.0006359121 3.221276e-05 1.901539e-04 8 673865 674047 183 - 1.968 1.811 -0.528
ENSG00000104714 E023 0.0000000       8 686642 686724 83 -      
ENSG00000104714 E024 10.7899143 0.0202512880 2.254393e-01 3.569358e-01 8 690898 691096 199 - 1.131 0.996 -0.493
ENSG00000104714 E025 71.6364038 0.0004680830 6.502871e-02 1.350837e-01 8 692478 692612 135 - 1.893 1.827 -0.224
ENSG00000104714 E026 26.9216685 0.0007498761 1.525313e-22 1.293492e-20 8 707821 708116 296 - 0.793 1.634 3.010
ENSG00000104714 E027 87.6621939 0.0003404371 1.761721e-02 4.630697e-02 8 715861 716007 147 - 1.885 1.981 0.321
ENSG00000104714 E028 45.4277074 0.0005516206 2.983333e-01 4.397746e-01 8 731140 731234 95 - 1.627 1.688 0.208
ENSG00000104714 E029 0.0000000       8 737784 738106 323 -