ENSG00000104695

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221138 ENSG00000104695 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2CB protein_coding protein_coding 26.66592 18.6247 34.80884 2.968089 1.29972 0.9018765 21.959591 18.32773 30.168012 2.89737 0.5581566 0.7186827 0.8349917 0.9844 0.8679333 -0.1164667 1.707138e-12 4.618223e-21 FALSE TRUE
ENST00000518243 ENSG00000104695 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2CB protein_coding protein_coding 26.66592 18.6247 34.80884 2.968089 1.29972 0.9018765 4.275537 0.00000 4.203128 0.00000 0.7227898 8.7187478 0.1468458 0.0000 0.1195667 0.1195667 4.618223e-21 4.618223e-21 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104695 E001 1.1112043 0.1588117009 6.651600e-03 2.032002e-02 8 30774457 30774625 169 - 0.000 0.562 14.601
ENSG00000104695 E002 0.8114974 0.0162263213 8.184785e-02 1.624566e-01 8 30774796 30774832 37 - 0.104 0.408 2.527
ENSG00000104695 E003 2.1723624 0.0070443776 4.438394e-02 9.907743e-02 8 30774833 30774930 98 - 0.319 0.655 1.699
ENSG00000104695 E004 253.0327677 0.0022860432 1.321457e-09 1.914985e-08 8 30785616 30785989 374 - 2.312 2.505 0.644
ENSG00000104695 E005 238.4474306 0.0009224910 1.137176e-02 3.205161e-02 8 30785990 30786108 119 - 2.351 2.423 0.241
ENSG00000104695 E006 134.6132121 0.0002328085 2.339723e-01 3.671049e-01 8 30786109 30786128 20 - 2.118 2.159 0.138
ENSG00000104695 E007 174.5751257 0.0013657720 2.007189e-01 3.270934e-01 8 30786129 30786210 82 - 2.228 2.271 0.146
ENSG00000104695 E008 206.8572229 0.0037208233 3.381469e-01 4.820235e-01 8 30786211 30786307 97 - 2.302 2.338 0.118
ENSG00000104695 E009 0.2987644 0.0273375897 3.305970e-01   8 30786432 30786488 57 - 0.188 0.000 -12.090
ENSG00000104695 E010 0.0000000       8 30790990 30791196 207 -      
ENSG00000104695 E011 240.9660180 0.0008919142 7.010474e-01 8.003673e-01 8 30791197 30791315 119 - 2.390 2.386 -0.015
ENSG00000104695 E012 0.5997190 0.1354684872 1.123498e-01 2.089710e-01 8 30791316 30791563 248 - 0.319 0.000 -13.093
ENSG00000104695 E013 1.9594275 0.0080269555 1.735273e-01 2.927697e-01 8 30793116 30793916 801 - 0.569 0.337 -1.209
ENSG00000104695 E014 168.6876890 0.0033726358 5.535014e-01 6.826192e-01 8 30793917 30793961 45 - 2.242 2.227 -0.048
ENSG00000104695 E015 242.0036217 0.0002423220 5.401557e-01 6.713391e-01 8 30793962 30794078 117 - 2.395 2.386 -0.031
ENSG00000104695 E016 113.9602133 0.0003003023 9.578003e-01 9.775476e-01 8 30794192 30794197 6 - 2.065 2.068 0.011
ENSG00000104695 E017 226.5251323 0.0001942508 3.750322e-01 5.194490e-01 8 30794198 30794281 84 - 2.369 2.353 -0.053
ENSG00000104695 E018 0.4545463 0.6456398337 4.177833e-01 5.611011e-01 8 30794282 30794490 209 - 0.260 0.000 -12.688
ENSG00000104695 E019 320.8146406 0.0001744634 2.848516e-02 6.898356e-02 8 30797581 30797754 174 - 2.528 2.489 -0.129
ENSG00000104695 E020 166.2196376 0.0002674173 1.227578e-01 2.238940e-01 8 30799546 30799580 35 - 2.243 2.204 -0.129
ENSG00000104695 E021 199.5034420 0.0001975936 5.980526e-02 1.262810e-01 8 30799581 30799648 68 - 2.324 2.282 -0.142
ENSG00000104695 E022 186.6596100 0.0003188038 1.845788e-02 4.813730e-02 8 30799649 30799716 68 - 2.301 2.243 -0.196
ENSG00000104695 E023 141.7879936 0.0024729531 3.856984e-02 8.840162e-02 8 30799717 30799755 39 - 2.191 2.110 -0.272
ENSG00000104695 E024 0.4439371 0.0215607106 1.616606e-01 2.772767e-01 8 30809990 30810276 287 - 0.258 0.000 -12.675
ENSG00000104695 E025 191.6077059 0.0069905706 1.170177e-01 2.156988e-01 8 30812320 30812785 466 - 2.321 2.235 -0.287
ENSG00000104695 E026 27.3141190 0.0303678778 1.895015e-01 3.131230e-01 8 30812786 30812878 93 - 1.514 1.360 -0.532
ENSG00000104695 E027 0.0000000       8 30813887 30814314 428 -