ENSG00000104687

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000221130 ENSG00000104687 HEK293_OSMI2_2hA HEK293_TMG_2hB GSR protein_coding protein_coding 29.36012 23.8957 35.33549 2.352811 0.7765827 0.5641712 17.88253 23.0487810 17.75387 2.5944074 0.6899043 -0.376370 0.6502583 0.96233333 0.5024 -0.4599333 1.211172e-06 1.211172e-06 FALSE TRUE
MSTRG.31360.4 ENSG00000104687 HEK293_OSMI2_2hA HEK293_TMG_2hB GSR protein_coding   29.36012 23.8957 35.33549 2.352811 0.7765827 0.5641712 11.00051 0.6925555 16.66667 0.5249843 0.6922948 4.569076 0.3347417 0.03086667 0.4716 0.4407333 4.189552e-03 1.211172e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104687 E001 91.5496785 0.0004720373 9.793227e-16 3.700973e-14 8 30678066 30678368 303 - 1.770 2.099 1.107
ENSG00000104687 E002 675.1650658 0.0019196099 3.382714e-34 7.824725e-32 8 30678369 30679265 897 - 2.653 2.947 0.976
ENSG00000104687 E003 77.4195065 0.0005040392 1.714319e-52 1.194017e-49 8 30679266 30679304 39 - 1.360 2.110 2.545
ENSG00000104687 E004 257.9072225 0.0015921016 1.764098e-08 2.078248e-07 8 30679305 30679519 215 - 2.314 2.493 0.597
ENSG00000104687 E005 346.3039843 0.0003245222 2.196079e-02 5.559142e-02 8 30679520 30679669 150 - 2.558 2.531 -0.090
ENSG00000104687 E006 327.6666779 0.0001572584 1.885644e-05 1.176607e-04 8 30680904 30681037 134 - 2.553 2.488 -0.216
ENSG00000104687 E007 134.3545223 0.0002515524 3.500862e-03 1.172790e-02 8 30681930 30681930 1 - 2.169 2.097 -0.238
ENSG00000104687 E008 285.1485133 0.0010475441 8.740294e-03 2.563750e-02 8 30681931 30682061 131 - 2.483 2.432 -0.168
ENSG00000104687 E009 263.9964153 0.0009432208 3.520837e-04 1.588426e-03 8 30684088 30684199 112 - 2.462 2.387 -0.250
ENSG00000104687 E010 0.0000000       8 30687523 30687639 117 -      
ENSG00000104687 E011 302.3646834 0.0001987223 2.229282e-05 1.367076e-04 8 30689161 30689319 159 - 2.520 2.452 -0.228
ENSG00000104687 E012 193.7988849 0.0002522706 1.808352e-02 4.730883e-02 8 30692969 30693055 87 - 2.316 2.274 -0.140
ENSG00000104687 E013 124.6772992 0.0004314449 3.434516e-01 4.874871e-01 8 30696380 30696404 25 - 2.109 2.097 -0.041
ENSG00000104687 E014 175.0489490 0.0016850275 5.509560e-03 1.731334e-02 8 30696405 30696479 75 - 2.285 2.211 -0.248
ENSG00000104687 E015 142.6447617 0.0018358074 1.385770e-03 5.260754e-03 8 30700081 30700135 55 - 2.208 2.109 -0.330
ENSG00000104687 E016 212.6435130 0.0029316832 6.940280e-04 2.877120e-03 8 30703093 30703240 148 - 2.384 2.277 -0.356
ENSG00000104687 E017 0.1515154 0.0429247284 5.156783e-01   8 30704647 30704864 218 - 0.118 0.000 -9.684
ENSG00000104687 E018 0.2987644 0.0294454426 2.156796e-01   8 30706990 30707104 115 - 0.211 0.000 -10.684
ENSG00000104687 E019 146.0034123 0.0103523853 8.426631e-03 2.485482e-02 8 30708072 30708141 70 - 2.237 2.095 -0.474
ENSG00000104687 E020 128.3842912 0.0025110969 1.788829e-06 1.406409e-05 8 30709814 30709902 89 - 2.196 2.024 -0.578
ENSG00000104687 E021 68.3776711 0.0003938547 9.799447e-06 6.529300e-05 8 30712062 30712088 27 - 1.925 1.755 -0.576
ENSG00000104687 E022 0.3686942 0.0266364823 9.865172e-01 9.956355e-01 8 30726893 30727010 118 - 0.118 0.127 0.116
ENSG00000104687 E023 98.8849962 0.0101741832 5.438233e-08 5.814554e-07 8 30727530 30727846 317 - 2.140 1.817 -1.086
ENSG00000104687 E024 1.3545117 0.0653395148 1.324040e-01 2.374279e-01 8 30728047 30728145 99 - 0.503 0.224 -1.697