Isoforom Switch Analysis
WANG Ziyi
Date: 19 5月 2022
ENSG00000104517
1 Isoform Switch
Summary Plot
Only the isoforms with fraction > 5% are shown below.
Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.
For the function of any other domain, please Click HERE to search it through Pfam database.
Results
| isoform_id | gene_id | condition_1 | condition_2 | gene_name | gene_biotype | iso_biotype | gene_overall_mean | gene_value_1 | gene_value_2 | gene_stderr_1 | gene_stderr_2 | gene_log2_fold_change | iso_overall_mean | iso_value_1 | iso_value_2 | iso_stderr_1 | iso_stderr_2 | iso_log2_fold_change | IF_overall | IF1 | IF2 | dIF | isoform_switch_q_value | gene_switch_q_value | PTC | codingPotential |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ENST00000220959 | ENSG00000104517 | HEK293_OSMI2_2hA | HEK293_TMG_2hB | UBR5 | protein_coding | protein_coding | 20.68175 | 17.63375 | 19.9599 | 0.5420621 | 0.9428998 | 0.1786699 | 2.6338638 | 0.32970037 | 3.031328 | 0.32970037 | 0.6754142 | 3.1623669 | 0.11650833 | 0.017600000 | 0.15386667 | 0.13626667 | 6.276303e-02 | 1.137518e-07 | FALSE | TRUE |
| ENST00000517465 | ENSG00000104517 | HEK293_OSMI2_2hA | HEK293_TMG_2hB | UBR5 | protein_coding | retained_intron | 20.68175 | 17.63375 | 19.9599 | 0.5420621 | 0.9428998 | 0.1786699 | 3.6200503 | 5.91716031 | 1.431780 | 0.57873779 | 0.3167687 | -2.0394898 | 0.18715000 | 0.337733333 | 0.07053333 | -0.26720000 | 3.468325e-07 | 1.137518e-07 | TRUE | TRUE |
| ENST00000518205 | ENSG00000104517 | HEK293_OSMI2_2hA | HEK293_TMG_2hB | UBR5 | protein_coding | protein_coding | 20.68175 | 17.63375 | 19.9599 | 0.5420621 | 0.9428998 | 0.1786699 | 4.3213548 | 6.21036844 | 2.763911 | 0.09124146 | 0.6331850 | -1.1650786 | 0.21990417 | 0.353133333 | 0.13616667 | -0.21696667 | 2.509485e-04 | 1.137518e-07 | FALSE | TRUE |
| ENST00000520539 | ENSG00000104517 | HEK293_OSMI2_2hA | HEK293_TMG_2hB | UBR5 | protein_coding | protein_coding | 20.68175 | 17.63375 | 19.9599 | 0.5420621 | 0.9428998 | 0.1786699 | 4.3830599 | 3.62891447 | 4.839042 | 0.35618609 | 0.4959225 | 0.4141915 | 0.21341667 | 0.205000000 | 0.24280000 | 0.03780000 | 6.067309e-01 | 1.137518e-07 | FALSE | TRUE |
| ENST00000521566 | ENSG00000104517 | HEK293_OSMI2_2hA | HEK293_TMG_2hB | UBR5 | protein_coding | protein_coding | 20.68175 | 17.63375 | 19.9599 | 0.5420621 | 0.9428998 | 0.1786699 | 0.4739464 | 0.96365980 | 0.000000 | 0.48185956 | 0.0000000 | -6.6053459 | 0.02277917 | 0.053966667 | 0.00000000 | -0.05396667 | 1.657038e-01 | 1.137518e-07 | FALSE | FALSE |
| MSTRG.31937.3 | ENSG00000104517 | HEK293_OSMI2_2hA | HEK293_TMG_2hB | UBR5 | protein_coding | 20.68175 | 17.63375 | 19.9599 | 0.5420621 | 0.9428998 | 0.1786699 | 1.1225446 | 0.09171159 | 2.058089 | 0.09171159 | 0.2254772 | 4.3457424 | 0.05484583 | 0.004900000 | 0.10250000 | 0.09760000 | 3.692450e-03 | 1.137518e-07 | FALSE | TRUE | |
| MSTRG.31937.5 | ENSG00000104517 | HEK293_OSMI2_2hA | HEK293_TMG_2hB | UBR5 | protein_coding | 20.68175 | 17.63375 | 19.9599 | 0.5420621 | 0.9428998 | 0.1786699 | 2.7746647 | 0.07223413 | 4.162022 | 0.07223413 | 0.2676341 | 5.6648658 | 0.12145417 | 0.003866667 | 0.21083333 | 0.20696667 | 2.304114e-05 | 1.137518e-07 | FALSE | TRUE |
- Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.
2 Differential Exon Usage
Counts
All exons whithin this gene region are shown and numbering below.
Expression
All exons whithin this gene region are shown and numbering below.
Splicing
All exons whithin this gene region are shown and numbering below.
Transcripts
All isoforms whithin this gene region are shown below.
Results
| groupID | featureID | exonBaseMean | dispersion | pvalue | padj | seqnames | start | end | width | strand | HEK293_TMG_2hB | HEK293_OSMI2_2hA | log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ENSG00000104517 | E001 | 145.1215982 | 0.0080071120 | 1.296793e-06 | 1.051325e-05 | 8 | 102252273 | 102253735 | 1463 | - | 2.033 | 2.301 | 0.896 |
| ENSG00000104517 | E002 | 102.3164438 | 0.0003116351 | 6.348505e-17 | 2.799593e-15 | 8 | 102253736 | 102253945 | 210 | - | 1.861 | 2.172 | 1.042 |
| ENSG00000104517 | E003 | 179.0729167 | 0.0028314496 | 7.723341e-33 | 1.595599e-30 | 8 | 102253946 | 102254197 | 252 | - | 2.019 | 2.470 | 1.506 |
| ENSG00000104517 | E004 | 155.4783053 | 0.0056283546 | 1.554880e-20 | 1.059595e-18 | 8 | 102254198 | 102254350 | 153 | - | 1.965 | 2.405 | 1.472 |
| ENSG00000104517 | E005 | 197.1931164 | 0.0102149341 | 1.814446e-10 | 3.062829e-09 | 8 | 102254351 | 102254514 | 164 | - | 2.114 | 2.474 | 1.205 |
| ENSG00000104517 | E006 | 144.6444045 | 0.0107538391 | 2.829291e-08 | 3.200577e-07 | 8 | 102257632 | 102257717 | 86 | - | 1.994 | 2.328 | 1.116 |
| ENSG00000104517 | E007 | 4.2973272 | 0.0040627560 | 4.403860e-01 | 5.820658e-01 | 8 | 102258316 | 102258424 | 109 | - | 0.739 | 0.635 | -0.435 |
| ENSG00000104517 | E008 | 167.5620990 | 0.0074554360 | 3.685759e-09 | 4.917615e-08 | 8 | 102258985 | 102259129 | 145 | - | 2.073 | 2.378 | 1.017 |
| ENSG00000104517 | E009 | 142.1433342 | 0.0022730528 | 7.302796e-12 | 1.554486e-10 | 8 | 102261146 | 102261259 | 114 | - | 2.023 | 2.291 | 0.898 |
| ENSG00000104517 | E010 | 149.5464125 | 0.0007103519 | 4.569070e-15 | 1.581865e-13 | 8 | 102261915 | 102262070 | 156 | - | 2.048 | 2.307 | 0.869 |
| ENSG00000104517 | E011 | 98.5392416 | 0.0006166611 | 5.291640e-10 | 8.252947e-09 | 8 | 102264474 | 102264558 | 85 | - | 1.873 | 2.119 | 0.826 |
| ENSG00000104517 | E012 | 127.1829423 | 0.0028897597 | 5.975811e-04 | 2.524866e-03 | 8 | 102265100 | 102265202 | 103 | - | 2.029 | 2.183 | 0.514 |
| ENSG00000104517 | E013 | 80.1723961 | 0.0014671152 | 3.310134e-02 | 7.801240e-02 | 8 | 102265203 | 102265207 | 5 | - | 1.850 | 1.958 | 0.363 |
| ENSG00000104517 | E014 | 104.8895083 | 0.0033335765 | 1.988681e-02 | 5.124868e-02 | 8 | 102265208 | 102265275 | 68 | - | 1.962 | 2.080 | 0.393 |
| ENSG00000104517 | E015 | 51.9580245 | 0.0086119759 | 1.305876e-01 | 2.349758e-01 | 8 | 102265276 | 102265278 | 3 | - | 1.665 | 1.778 | 0.381 |
| ENSG00000104517 | E016 | 104.8682519 | 0.0044636209 | 3.629323e-02 | 8.414175e-02 | 8 | 102266947 | 102267007 | 61 | - | 1.964 | 2.076 | 0.375 |
| ENSG00000104517 | E017 | 5.4388988 | 0.0050132183 | 4.331873e-01 | 5.756152e-01 | 8 | 102267008 | 102267092 | 85 | - | 0.819 | 0.721 | -0.394 |
| ENSG00000104517 | E018 | 33.4963083 | 0.0006046397 | 1.105519e-08 | 1.351906e-07 | 8 | 102267093 | 102268977 | 1885 | - | 1.625 | 1.233 | -1.357 |
| ENSG00000104517 | E019 | 126.1611000 | 0.0051130909 | 7.163598e-04 | 2.957466e-03 | 8 | 102268978 | 102269108 | 131 | - | 2.019 | 2.189 | 0.571 |
| ENSG00000104517 | E020 | 128.4948760 | 0.0002566404 | 3.356922e-06 | 2.486837e-05 | 8 | 102270039 | 102270183 | 145 | - | 2.030 | 2.193 | 0.547 |
| ENSG00000104517 | E021 | 90.7772028 | 0.0004356311 | 6.275572e-06 | 4.369628e-05 | 8 | 102271134 | 102271193 | 60 | - | 1.868 | 2.055 | 0.630 |
| ENSG00000104517 | E022 | 93.7721345 | 0.0008941349 | 5.349656e-05 | 2.992253e-04 | 8 | 102271194 | 102271245 | 52 | - | 1.890 | 2.062 | 0.580 |
| ENSG00000104517 | E023 | 182.5642819 | 0.0002227830 | 4.993763e-09 | 6.518213e-08 | 8 | 102272529 | 102272772 | 244 | - | 2.176 | 2.349 | 0.576 |
| ENSG00000104517 | E024 | 0.2924217 | 0.0272374285 | 4.797628e-01 | 8 | 102272773 | 102272931 | 159 | - | 0.161 | 0.000 | -10.887 | |
| ENSG00000104517 | E025 | 100.1759794 | 0.0003135902 | 2.075380e-05 | 1.282537e-04 | 8 | 102275521 | 102275619 | 99 | - | 1.918 | 2.087 | 0.567 |
| ENSG00000104517 | E026 | 102.9698909 | 0.0004988343 | 6.700438e-05 | 3.656569e-04 | 8 | 102275708 | 102275828 | 121 | - | 1.938 | 2.098 | 0.536 |
| ENSG00000104517 | E027 | 0.2944980 | 0.3708431719 | 5.922366e-01 | 8 | 102276774 | 102276971 | 198 | - | 0.161 | 0.000 | -10.886 | |
| ENSG00000104517 | E028 | 125.5602099 | 0.0002807585 | 1.357865e-03 | 5.169392e-03 | 8 | 102276972 | 102277192 | 221 | - | 2.040 | 2.159 | 0.400 |
| ENSG00000104517 | E029 | 99.4957645 | 0.0007429553 | 2.783856e-01 | 4.180750e-01 | 8 | 102278826 | 102278939 | 114 | - | 1.963 | 2.020 | 0.189 |
| ENSG00000104517 | E030 | 130.6881134 | 0.0002712381 | 1.720848e-02 | 4.540332e-02 | 8 | 102279036 | 102279208 | 173 | - | 2.066 | 2.158 | 0.306 |
| ENSG00000104517 | E031 | 96.2038605 | 0.0003154833 | 7.379370e-01 | 8.279666e-01 | 8 | 102280394 | 102280467 | 74 | - | 1.963 | 1.991 | 0.092 |
| ENSG00000104517 | E032 | 138.9860261 | 0.0002262208 | 8.227905e-01 | 8.882536e-01 | 8 | 102281289 | 102281519 | 231 | - | 2.123 | 2.145 | 0.074 |
| ENSG00000104517 | E033 | 96.7547837 | 0.0003885391 | 6.014117e-01 | 7.225430e-01 | 8 | 102285127 | 102285244 | 118 | - | 1.962 | 1.997 | 0.117 |
| ENSG00000104517 | E034 | 67.0932632 | 0.0004418105 | 4.297740e-01 | 5.724367e-01 | 8 | 102285245 | 102285338 | 94 | - | 1.798 | 1.848 | 0.170 |
| ENSG00000104517 | E035 | 109.2186932 | 0.0002978623 | 8.298419e-01 | 8.931815e-01 | 8 | 102285513 | 102285781 | 269 | - | 2.016 | 2.039 | 0.076 |
| ENSG00000104517 | E036 | 97.2956166 | 0.0033509278 | 8.883048e-02 | 1.733270e-01 | 8 | 102286360 | 102286617 | 258 | - | 1.998 | 1.933 | -0.218 |
| ENSG00000104517 | E037 | 53.2547845 | 0.0101751222 | 4.624144e-01 | 6.022762e-01 | 8 | 102287433 | 102287504 | 72 | - | 1.730 | 1.693 | -0.123 |
| ENSG00000104517 | E038 | 64.4729515 | 0.0028188870 | 1.159768e-01 | 2.142053e-01 | 8 | 102287505 | 102287564 | 60 | - | 1.822 | 1.755 | -0.228 |
| ENSG00000104517 | E039 | 82.7666844 | 0.0003280217 | 5.527806e-03 | 1.735974e-02 | 8 | 102288155 | 102288266 | 112 | - | 1.941 | 1.840 | -0.340 |
| ENSG00000104517 | E040 | 70.3599818 | 0.0006094267 | 5.028354e-04 | 2.170589e-03 | 8 | 102289453 | 102289528 | 76 | - | 1.883 | 1.736 | -0.497 |
| ENSG00000104517 | E041 | 61.2381213 | 0.0049001442 | 5.659621e-03 | 1.771262e-02 | 8 | 102289529 | 102289576 | 48 | - | 1.825 | 1.676 | -0.502 |
| ENSG00000104517 | E042 | 109.3851505 | 0.0065471503 | 4.639815e-04 | 2.022036e-03 | 8 | 102293605 | 102293844 | 240 | - | 2.081 | 1.910 | -0.573 |
| ENSG00000104517 | E043 | 69.5824133 | 0.0016707773 | 3.126652e-05 | 1.852480e-04 | 8 | 102293955 | 102294115 | 161 | - | 1.894 | 1.701 | -0.652 |
| ENSG00000104517 | E044 | 58.4269519 | 0.0056636962 | 6.830063e-04 | 2.836738e-03 | 8 | 102294982 | 102295111 | 130 | - | 1.821 | 1.624 | -0.665 |
| ENSG00000104517 | E045 | 67.8986077 | 0.0003806448 | 1.765626e-05 | 1.108509e-04 | 8 | 102295204 | 102295330 | 127 | - | 1.883 | 1.696 | -0.632 |
| ENSG00000104517 | E046 | 75.4722444 | 0.0003407671 | 5.559270e-06 | 3.916067e-05 | 8 | 102295414 | 102295532 | 119 | - | 1.928 | 1.740 | -0.635 |
| ENSG00000104517 | E047 | 80.8542545 | 0.0048191003 | 1.087783e-04 | 5.624841e-04 | 8 | 102295636 | 102295782 | 147 | - | 1.960 | 1.764 | -0.662 |
| ENSG00000104517 | E048 | 67.9408264 | 0.0004748757 | 1.074219e-06 | 8.856241e-06 | 8 | 102296893 | 102296984 | 92 | - | 1.890 | 1.671 | -0.739 |
| ENSG00000104517 | E049 | 74.3020634 | 0.0026671091 | 7.385221e-09 | 9.323035e-08 | 8 | 102297458 | 102297606 | 149 | - | 1.947 | 1.657 | -0.978 |
| ENSG00000104517 | E050 | 56.0330468 | 0.0006527498 | 2.855846e-04 | 1.321232e-03 | 8 | 102298392 | 102298489 | 98 | - | 1.798 | 1.625 | -0.587 |
| ENSG00000104517 | E051 | 28.7595063 | 0.0006896277 | 1.402995e-04 | 7.048907e-04 | 8 | 102298848 | 102298859 | 12 | - | 1.539 | 1.278 | -0.902 |
| ENSG00000104517 | E052 | 30.0751637 | 0.0006617756 | 1.837643e-07 | 1.773851e-06 | 8 | 102298860 | 102298866 | 7 | - | 1.579 | 1.208 | -1.288 |
| ENSG00000104517 | E053 | 54.1898431 | 0.0004715615 | 8.126000e-07 | 6.879592e-06 | 8 | 102298867 | 102298971 | 105 | - | 1.801 | 1.551 | -0.850 |
| ENSG00000104517 | E054 | 39.3359119 | 0.0005500973 | 2.442872e-05 | 1.485697e-04 | 8 | 102299452 | 102299496 | 45 | - | 1.665 | 1.416 | -0.851 |
| ENSG00000104517 | E055 | 35.0408635 | 0.0006036704 | 6.486609e-06 | 4.500856e-05 | 8 | 102299497 | 102299547 | 51 | - | 1.625 | 1.339 | -0.985 |
| ENSG00000104517 | E056 | 58.6986274 | 0.0037142220 | 6.259112e-08 | 6.615543e-07 | 8 | 102300000 | 102300151 | 152 | - | 1.850 | 1.539 | -1.056 |
| ENSG00000104517 | E057 | 8.8818858 | 0.0019586724 | 5.143334e-05 | 2.889048e-04 | 8 | 102302271 | 102302481 | 211 | - | 1.110 | 0.584 | -2.064 |
| ENSG00000104517 | E058 | 58.0446454 | 0.0019389430 | 2.394561e-08 | 2.749181e-07 | 8 | 102304043 | 102304166 | 124 | - | 1.841 | 1.539 | -1.022 |
| ENSG00000104517 | E059 | 28.2807928 | 0.0072367702 | 3.749041e-07 | 3.399112e-06 | 8 | 102304167 | 102304169 | 3 | - | 1.563 | 1.124 | -1.531 |
| ENSG00000104517 | E060 | 80.9098479 | 0.0005171370 | 1.895273e-17 | 8.953959e-16 | 8 | 102305085 | 102305295 | 211 | - | 2.001 | 1.615 | -1.303 |
| ENSG00000104517 | E061 | 75.4366569 | 0.0023323950 | 5.271943e-10 | 8.224258e-09 | 8 | 102311299 | 102311496 | 198 | - | 1.954 | 1.645 | -1.044 |
| ENSG00000104517 | E062 | 57.8326907 | 0.0291469550 | 5.294526e-04 | 2.269714e-03 | 8 | 102311735 | 102311889 | 155 | - | 1.842 | 1.531 | -1.057 |
| ENSG00000104517 | E063 | 49.9225695 | 0.0625679267 | 5.532889e-03 | 1.737369e-02 | 8 | 102312134 | 102312245 | 112 | - | 1.783 | 1.450 | -1.136 |
| ENSG00000104517 | E064 | 55.7595458 | 0.0198816172 | 2.366280e-04 | 1.119117e-03 | 8 | 102312342 | 102312485 | 144 | - | 1.824 | 1.519 | -1.038 |
| ENSG00000104517 | E065 | 58.7434967 | 0.0221336629 | 4.901225e-06 | 3.495811e-05 | 8 | 102313804 | 102313916 | 113 | - | 1.867 | 1.469 | -1.352 |
| ENSG00000104517 | E066 | 53.2593899 | 0.0041708579 | 9.601190e-17 | 4.139546e-15 | 8 | 102314744 | 102314853 | 110 | - | 1.853 | 1.289 | -1.930 |
| ENSG00000104517 | E067 | 61.9149896 | 0.0175077718 | 1.340726e-07 | 1.329198e-06 | 8 | 102323311 | 102323495 | 185 | - | 1.895 | 1.469 | -1.447 |
| ENSG00000104517 | E068 | 52.6969012 | 0.0166738144 | 3.093790e-06 | 2.307426e-05 | 8 | 102326546 | 102326663 | 118 | - | 1.818 | 1.439 | -1.288 |
| ENSG00000104517 | E069 | 62.2755454 | 0.0224364797 | 1.608838e-06 | 1.277515e-05 | 8 | 102327742 | 102327896 | 155 | - | 1.895 | 1.477 | -1.419 |
| ENSG00000104517 | E070 | 49.7228691 | 0.0020578734 | 4.041678e-13 | 1.055097e-11 | 8 | 102329090 | 102329200 | 111 | - | 1.806 | 1.357 | -1.532 |
| ENSG00000104517 | E071 | 54.0375991 | 0.0017309569 | 1.612811e-12 | 3.816415e-11 | 8 | 102329283 | 102329399 | 117 | - | 1.834 | 1.424 | -1.395 |
| ENSG00000104517 | E072 | 72.3593027 | 0.0265986209 | 3.666169e-06 | 2.691929e-05 | 8 | 102342473 | 102342666 | 194 | - | 1.958 | 1.551 | -1.379 |
| ENSG00000104517 | E073 | 20.5384858 | 0.0965284328 | 7.671398e-04 | 3.140338e-03 | 8 | 102342667 | 102342684 | 18 | - | 1.449 | 0.907 | -1.938 |
| ENSG00000104517 | E074 | 68.8216644 | 0.0174393270 | 8.870969e-08 | 9.094039e-07 | 8 | 102345396 | 102345545 | 150 | - | 1.939 | 1.515 | -1.437 |
| ENSG00000104517 | E075 | 0.1515154 | 0.0432767170 | 1.000000e+00 | 8 | 102345896 | 102346235 | 340 | - | 0.088 | 0.000 | -9.888 | |
| ENSG00000104517 | E076 | 61.8499283 | 0.0018348541 | 3.514164e-16 | 1.410184e-14 | 8 | 102346236 | 102346395 | 160 | - | 1.900 | 1.439 | -1.564 |
| ENSG00000104517 | E077 | 55.2599236 | 0.0034837835 | 1.215288e-13 | 3.412878e-12 | 8 | 102346903 | 102347092 | 190 | - | 1.852 | 1.384 | -1.593 |
| ENSG00000104517 | E078 | 0.0000000 | 8 | 102359652 | 102360070 | 419 | - | ||||||
| ENSG00000104517 | E079 | 42.2756685 | 0.0025975775 | 6.557010e-13 | 1.659150e-11 | 8 | 102360071 | 102360190 | 120 | - | 1.742 | 1.245 | -1.708 |
| ENSG00000104517 | E080 | 36.7044446 | 0.0005478721 | 3.362310e-13 | 8.870345e-12 | 8 | 102360589 | 102360665 | 77 | - | 1.685 | 1.182 | -1.742 |
| ENSG00000104517 | E081 | 39.2849402 | 0.0005295693 | 5.275630e-16 | 2.066265e-14 | 8 | 102361125 | 102361206 | 82 | - | 1.724 | 1.168 | -1.921 |
| ENSG00000104517 | E082 | 0.0000000 | 8 | 102361207 | 102361209 | 3 | - | ||||||
| ENSG00000104517 | E083 | 26.4378858 | 0.0007155940 | 6.671148e-11 | 1.211891e-09 | 8 | 102361582 | 102361626 | 45 | - | 1.553 | 1.019 | -1.875 |
| ENSG00000104517 | E084 | 44.3552321 | 0.0006402448 | 1.865083e-17 | 8.826741e-16 | 8 | 102412173 | 102412759 | 587 | - | 1.774 | 1.220 | -1.905 |