ENSG00000104447

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220888 ENSG00000104447 HEK293_OSMI2_2hA HEK293_TMG_2hB TRPS1 protein_coding protein_coding 1.566094 0.4358183 1.940664 0.0324621 0.06966911 2.129438 0.4379831 0.00000000 0.6237580 0.00000000 0.05426082 5.9858602 0.1782083 0.0000000 0.3209000 0.3209000 4.868065e-05 4.868065e-05 FALSE TRUE
ENST00000395715 ENSG00000104447 HEK293_OSMI2_2hA HEK293_TMG_2hB TRPS1 protein_coding protein_coding 1.566094 0.4358183 1.940664 0.0324621 0.06966911 2.129438 0.5568873 0.05592423 0.7267030 0.05592423 0.13417190 3.4822023 0.3626833 0.1176333 0.3751333 0.2575000 2.328552e-01 4.868065e-05 FALSE TRUE
ENST00000640765 ENSG00000104447 HEK293_OSMI2_2hA HEK293_TMG_2hB TRPS1 protein_coding protein_coding 1.566094 0.4358183 1.940664 0.0324621 0.06966911 2.129438 0.4014080 0.37989403 0.5324114 0.04433759 0.13041791 0.4763054 0.3517375 0.8823667 0.2757000 -0.6066667 1.014960e-02 4.868065e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104447 E001 97.6952780 0.0008021709 7.408825e-15 2.489499e-13 8 115408496 115412548 4053 - 1.860 2.108 0.832
ENSG00000104447 E002 36.1199698 0.0069975368 6.126008e-01 7.314953e-01 8 115412549 115413813 1265 - 1.530 1.493 -0.128
ENSG00000104447 E003 5.6894413 0.0049903327 2.086671e-01 3.369044e-01 8 115413814 115413921 108 - 0.738 0.908 0.667
ENSG00000104447 E004 20.1880773 0.0112360180 8.393462e-01 8.996057e-01 8 115413922 115414428 507 - 1.276 1.297 0.074
ENSG00000104447 E005 27.0040012 0.0014191833 8.867559e-01 9.315724e-01 8 115414429 115415084 656 - 1.403 1.392 -0.038
ENSG00000104447 E006 9.5087808 0.0114370220 2.945487e-01 4.356419e-01 8 115418330 115418452 123 - 1.013 0.875 -0.516
ENSG00000104447 E007 0.0000000       8 115492188 115492221 34 -      
ENSG00000104447 E008 0.0000000       8 115515190 115515283 94 -      
ENSG00000104447 E009 23.2578366 0.0015999994 2.064910e-02 5.284723e-02 8 115587001 115587604 604 - 1.381 1.182 -0.698
ENSG00000104447 E010 11.1158738 0.0017108328 4.440906e-01 5.856628e-01 8 115603873 115604050 178 - 1.056 0.968 -0.323
ENSG00000104447 E011 21.3800417 0.0008497667 1.171525e-01 2.158779e-01 8 115604051 115604650 600 - 1.334 1.199 -0.474
ENSG00000104447 E012 16.3321656 0.0010854256 3.416245e-04 1.546654e-03 8 115604651 115605002 352 - 1.268 0.876 -1.428
ENSG00000104447 E013 17.8013855 0.0072068558 1.285253e-05 8.324924e-05 8 115619132 115619709 578 - 1.319 0.801 -1.899
ENSG00000104447 E014 4.4631264 0.0035552801 7.499848e-01 8.367858e-01 8 115619710 115619746 37 - 0.709 0.658 -0.211
ENSG00000104447 E015 3.5849308 0.0140715813 8.772892e-01 9.251629e-01 8 115619747 115619773 27 - 0.625 0.598 -0.119
ENSG00000104447 E016 4.4601197 0.0062748670 4.420927e-01 5.837472e-01 8 115619774 115619847 74 - 0.724 0.598 -0.535
ENSG00000104447 E017 4.6134839 0.0099588390 3.955095e-01 5.393210e-01 8 115619848 115619912 65 - 0.738 0.598 -0.593
ENSG00000104447 E018 5.7498719 0.0168928590 3.346837e-01 4.784223e-01 8 115619913 115620060 148 - 0.816 0.659 -0.636
ENSG00000104447 E019 0.0000000       8 115620061 115620070 10 -      
ENSG00000104447 E020 0.9244060 0.0136968632 7.092084e-01 8.066486e-01 8 115623601 115623610 10 - 0.277 0.202 -0.594
ENSG00000104447 E021 1.9574529 0.0072072890 1.418257e-01 2.505404e-01 8 115623611 115623758 148 - 0.498 0.202 -1.857
ENSG00000104447 E022 0.1451727 0.0438533007 1.000000e+00   8 115637234 115637330 97 - 0.071 0.000 -8.685
ENSG00000104447 E023 0.1472490 0.0438737061 1.000000e+00   8 115661570 115661678 109 - 0.071 0.000 -8.685
ENSG00000104447 E024 0.5891098 0.0184127182 3.292918e-01 4.727910e-01 8 115667874 115668294 421 - 0.234 0.000 -10.643
ENSG00000104447 E025 3.1270261 0.0588694290 3.701745e-02 8.550269e-02 8 115668545 115668975 431 - 0.660 0.202 -2.591
ENSG00000104447 E026 0.0000000       8 115669345 115669483 139 -      
ENSG00000104447 E027 0.0000000       8 115700936 115701072 137 -      
ENSG00000104447 E028 0.0000000       8 115809633 115809673 41 -