ENSG00000104412

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220853 ENSG00000104412 HEK293_OSMI2_2hA HEK293_TMG_2hB EMC2 protein_coding protein_coding 21.5356 7.589794 31.63658 0.3968481 0.6873178 2.058017 2.143694 1.344580 3.199543 0.1331099 0.3916372 1.244522 0.1203458 0.1779667 0.1010667 -0.0769000 5.654370e-02 2.302097e-14 FALSE TRUE
ENST00000517784 ENSG00000104412 HEK293_OSMI2_2hA HEK293_TMG_2hB EMC2 protein_coding processed_transcript 21.5356 7.589794 31.63658 0.3968481 0.6873178 2.058017 4.030098 0.000000 7.263454 0.0000000 1.2700966 9.506497 0.1356417 0.0000000 0.2304333 0.2304333 2.302097e-14 2.302097e-14 FALSE FALSE
MSTRG.32000.5 ENSG00000104412 HEK293_OSMI2_2hA HEK293_TMG_2hB EMC2 protein_coding   21.5356 7.589794 31.63658 0.3968481 0.6873178 2.058017 14.600346 5.945985 19.424903 0.2742987 1.4926985 1.706238 0.7139542 0.7841667 0.6126333 -0.1715333 5.017458e-03 2.302097e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104412 E001 0.2903454 0.2859520501 7.646739e-01   8 108443601 108443623 23 + 0.143 0.001 -7.719
ENSG00000104412 E002 0.5838113 0.3720581355 1.000000e+00 1.000000000 8 108443624 108443630 7 + 0.199 0.185 -0.128
ENSG00000104412 E003 0.5838113 0.3720581355 1.000000e+00 1.000000000 8 108443631 108443632 2 + 0.199 0.185 -0.128
ENSG00000104412 E004 0.5838113 0.3720581355 1.000000e+00 1.000000000 8 108443633 108443634 2 + 0.199 0.185 -0.128
ENSG00000104412 E005 3.7516223 0.0316414021 1.004699e-01 0.191181822 8 108443635 108443636 2 + 0.723 0.419 -1.397
ENSG00000104412 E006 87.8307491 0.0003036876 6.543490e-04 0.002731518 8 108443637 108443698 62 + 1.952 1.810 -0.478
ENSG00000104412 E007 1.1071294 0.0772305924 4.714324e-01 0.610543001 8 108446162 108446301 140 + 0.336 0.189 -1.099
ENSG00000104412 E008 143.1683117 0.0002274183 7.105402e-03 0.021500401 8 108449823 108449936 114 + 2.147 2.063 -0.281
ENSG00000104412 E009 77.0635425 0.0003302748 7.406068e-01 0.829975714 8 108450428 108450430 3 + 1.859 1.848 -0.038
ENSG00000104412 E010 123.3360911 0.0002380614 6.120387e-01 0.731063649 8 108450431 108450492 62 + 2.062 2.048 -0.047
ENSG00000104412 E011 117.2526735 0.0002913054 8.739624e-01 0.922999817 8 108453062 108453147 86 + 2.035 2.044 0.030
ENSG00000104412 E012 92.3066161 0.0002823210 4.234919e-01 0.566534178 8 108455873 108455930 58 + 1.923 1.957 0.116
ENSG00000104412 E013 1.2177581 0.2747604025 9.577447e-01 0.977506672 8 108455931 108456073 143 + 0.336 0.317 -0.123
ENSG00000104412 E014 0.0000000       8 108464047 108464132 86 +      
ENSG00000104412 E015 107.2235899 0.0002539555 1.843070e-01 0.306633894 8 108469826 108469911 86 + 2.011 1.965 -0.155
ENSG00000104412 E016 101.3860018 0.0004293818 1.147825e-01 0.212512311 8 108470062 108470121 60 + 1.989 1.931 -0.196
ENSG00000104412 E017 2.1307383 0.0085644544 2.759805e-01 0.415381677 8 108470854 108470962 109 + 0.524 0.319 -1.106
ENSG00000104412 E018 9.3626432 0.0355524924 1.157724e-04 0.000594512 8 108473851 108475881 2031 + 1.103 0.419 -2.844
ENSG00000104412 E019 112.0248877 0.0033423214 9.288073e-01 0.959222387 8 108475882 108475963 82 + 2.016 2.014 -0.007
ENSG00000104412 E020 131.9773140 0.0002638313 6.080617e-01 0.727919652 8 108476782 108476892 111 + 2.091 2.077 -0.046
ENSG00000104412 E021 117.6173912 0.0002651468 1.814126e-01 0.303013273 8 108479006 108479110 105 + 2.022 2.071 0.166
ENSG00000104412 E022 125.1255745 0.0009814819 1.673869e-03 0.006199356 8 108486512 108486599 88 + 2.025 2.138 0.379
ENSG00000104412 E023 163.5711755 0.0019235751 5.510767e-05 0.000307221 8 108486600 108488989 2390 + 2.133 2.273 0.467
ENSG00000104412 E024 9.6947981 0.0176481011 3.146956e-01 0.457429379 8 108488990 108489196 207 + 0.963 1.091 0.468