ENSG00000104381

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220822 ENSG00000104381 HEK293_OSMI2_2hA HEK293_TMG_2hB GDAP1 protein_coding protein_coding 8.775902 4.065742 16.63046 0.4353192 0.5626841 2.029561 4.3674510 2.230784 8.700047 0.06442939 0.5539260 1.958677 0.50525417 0.5619667 0.5224333 -0.03953333 8.646605e-01 5.072561e-11 FALSE TRUE
ENST00000522568 ENSG00000104381 HEK293_OSMI2_2hA HEK293_TMG_2hB GDAP1 protein_coding nonsense_mediated_decay 8.775902 4.065742 16.63046 0.4353192 0.5626841 2.029561 0.6893586 0.000000 2.124880 0.00000000 0.2867435 7.738011 0.05014583 0.0000000 0.1268667 0.12686667 5.072561e-11 5.072561e-11 FALSE TRUE
ENST00000676207 ENSG00000104381 HEK293_OSMI2_2hA HEK293_TMG_2hB GDAP1 protein_coding protein_coding 8.775902 4.065742 16.63046 0.4353192 0.5626841 2.029561 2.4927284 1.156917 3.572343 0.37088195 0.4535681 1.618202 0.27433750 0.2730667 0.2150333 -0.05803333 7.928244e-01 5.072561e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104381 E001 0.3268771 0.0316409816 0.3826818974   8 74320613 74320621 9 + 0.072 0.201 1.714
ENSG00000104381 E002 0.6192988 0.0235387209 0.9636415744 0.981066727 8 74320622 74320831 210 + 0.187 0.201 0.129
ENSG00000104381 E003 1.9552603 0.0078899636 0.4388320307 0.580668292 8 74320832 74320918 87 + 0.387 0.526 0.715
ENSG00000104381 E004 1.1468953 0.0113025797 0.2608104301 0.398391859 8 74320919 74320961 43 + 0.235 0.442 1.299
ENSG00000104381 E005 0.4482035 0.0261729276 0.4925609937 0.629714226 8 74321080 74321245 166 + 0.187 0.000 -13.155
ENSG00000104381 E006 0.0000000       8 74321440 74321504 65 +      
ENSG00000104381 E007 0.0000000       8 74321505 74321588 84 +      
ENSG00000104381 E008 0.3268771 0.0316409816 0.3826818974   8 74321694 74321866 173 + 0.072 0.201 1.714
ENSG00000104381 E009 0.2214452 0.0420066127 0.1360499745   8 74322264 74322475 212 + 0.000 0.202 12.786
ENSG00000104381 E010 0.5180316 0.0204822697 0.0062598298 0.019293377 8 74323786 74324224 439 + 0.000 0.442 14.475
ENSG00000104381 E011 0.1515154 0.0431473230 1.0000000000   8 74339571 74339887 317 + 0.072 0.000 -11.512
ENSG00000104381 E012 0.1817044 0.0430403098 0.1362877266   8 74350108 74350113 6 + 0.000 0.201 12.777
ENSG00000104381 E013 1.5030204 0.0986788792 0.3488485074 0.493067506 8 74350114 74350365 252 + 0.417 0.201 -1.452
ENSG00000104381 E014 0.1472490 0.0444148150 1.0000000000   8 74350395 74350395 1 + 0.072 0.000 -11.504
ENSG00000104381 E015 0.1472490 0.0444148150 1.0000000000   8 74350396 74350399 4 + 0.072 0.000 -11.504
ENSG00000104381 E016 0.1472490 0.0444148150 1.0000000000   8 74350400 74350402 3 + 0.072 0.000 -11.504
ENSG00000104381 E017 1.2523021 0.0261660291 0.4526157049 0.593460179 8 74350403 74350408 6 + 0.354 0.202 -1.091
ENSG00000104381 E018 5.1465814 0.0037933053 0.1053969395 0.198701676 8 74350409 74350412 4 + 0.793 0.526 -1.143
ENSG00000104381 E019 6.7028568 0.0029468139 0.4527033113 0.593546291 8 74350413 74350415 3 + 0.863 0.757 -0.415
ENSG00000104381 E020 8.5933961 0.0028302494 0.7274035999 0.820132656 8 74350416 74350417 2 + 0.923 0.966 0.163
ENSG00000104381 E021 13.8409501 0.0055274558 0.3022888807 0.444149293 8 74350418 74350425 8 + 1.091 1.197 0.380
ENSG00000104381 E022 16.5399561 0.0085119996 0.2624398688 0.400225765 8 74350426 74350433 8 + 1.161 1.272 0.391
ENSG00000104381 E023 20.3605909 0.0018728064 0.6005391757 0.721760242 8 74350434 74350443 10 + 1.266 1.311 0.158
ENSG00000104381 E024 21.0227510 0.0020988728 0.4708539441 0.610040867 8 74350444 74350445 2 + 1.274 1.335 0.214
ENSG00000104381 E025 21.9106253 0.0019067609 0.6606506359 0.769281668 8 74350446 74350453 8 + 1.298 1.335 0.129
ENSG00000104381 E026 33.1174462 0.0006896834 0.8496908935 0.906727825 8 74350454 74350472 19 + 1.479 1.492 0.046
ENSG00000104381 E027 44.7347535 0.0012465986 0.8578110983 0.912188154 8 74350473 74350530 58 + 1.612 1.601 -0.037
ENSG00000104381 E028 46.8326726 0.0005471109 0.9284205023 0.958958852 8 74350531 74350578 48 + 1.630 1.626 -0.016
ENSG00000104381 E029 0.0000000       8 74350745 74350972 228 +      
ENSG00000104381 E030 0.2924217 0.0274816365 0.8354005416   8 74351252 74351273 22 + 0.133 0.000 -12.587
ENSG00000104381 E031 40.3467737 0.0005526714 0.4131528161 0.556681708 8 74351274 74351297 24 + 1.582 1.531 -0.173
ENSG00000104381 E032 40.7000236 0.0023936050 0.8218972423 0.887694920 8 74351298 74351321 24 + 1.574 1.560 -0.046
ENSG00000104381 E033 37.9058517 0.0005888766 0.6634555295 0.771528204 8 74351322 74351339 18 + 1.532 1.561 0.096
ENSG00000104381 E034 64.9926557 0.0003799527 0.2544475534 0.391132362 8 74351340 74351418 79 + 1.755 1.810 0.187
ENSG00000104381 E035 52.4675948 0.0004299397 0.4691919218 0.608477502 8 74351419 74351453 35 + 1.669 1.708 0.134
ENSG00000104381 E036 35.6021595 0.0005906648 0.8405151592 0.900466400 8 74351454 74351466 13 + 1.521 1.508 -0.043
ENSG00000104381 E037 0.1472490 0.0444148150 1.0000000000   8 74351467 74351638 172 + 0.072 0.000 -11.504
ENSG00000104381 E038 35.7811963 0.0005533353 0.7224368494 0.816539751 8 74360137 74360140 4 + 1.523 1.500 -0.078
ENSG00000104381 E039 39.5499067 0.0005436379 0.9882632944 0.996733957 8 74360141 74360149 9 + 1.559 1.561 0.005
ENSG00000104381 E040 101.8718953 0.0003308284 0.2788557392 0.418525516 8 74360150 74360310 161 + 1.974 1.931 -0.144
ENSG00000104381 E041 82.3047271 0.0016903306 0.0388127877 0.088838273 8 74361884 74361978 95 + 1.898 1.798 -0.337
ENSG00000104381 E042 5.1164045 0.0036340231 0.2465541187 0.381911018 8 74361979 74362263 285 + 0.780 0.596 -0.772
ENSG00000104381 E043 2.8861122 0.0051801640 0.1525156462 0.265105943 8 74362264 74362351 88 + 0.608 0.338 -1.374
ENSG00000104381 E044 6.7569091 0.0023494277 0.0924746699 0.178986798 8 74362352 74362840 489 + 0.904 0.657 -0.987
ENSG00000104381 E045 1.5250553 0.1132703561 0.8389261212 0.899333179 8 74362841 74362938 98 + 0.388 0.337 -0.297
ENSG00000104381 E046 64.1498515 0.0028530325 0.0297394975 0.071444473 8 74362939 74363053 115 + 1.795 1.671 -0.421
ENSG00000104381 E047 0.2987644 0.0273890853 0.8348024569   8 74363054 74363371 318 + 0.133 0.000 -12.588
ENSG00000104381 E048 0.0000000       8 74363372 74363383 12 +      
ENSG00000104381 E049 0.4804688 0.0214592116 0.6792401042 0.783491583 8 74363384 74363449 66 + 0.133 0.201 0.714
ENSG00000104381 E050 1.4854032 0.0090290518 0.0422835619 0.095242836 8 74363450 74363943 494 + 0.447 0.000 -14.872
ENSG00000104381 E051 0.7707005 0.7476826865 0.8570807619 0.911696814 8 74363944 74363984 41 + 0.235 0.202 -0.273
ENSG00000104381 E052 26.7735133 0.0034036325 0.0755826204 0.152443875 8 74363985 74363987 3 + 1.432 1.284 -0.513
ENSG00000104381 E053 77.7904906 0.0011233653 0.0073547884 0.022139391 8 74363988 74364163 176 + 1.878 1.746 -0.445
ENSG00000104381 E054 585.7839321 0.0004157597 0.0035590191 0.011894811 8 74364164 74368060 3897 + 2.707 2.749 0.140
ENSG00000104381 E055 0.0000000       8 74438624 74438743 120 +      
ENSG00000104381 E056 0.0000000       8 74438744 74439798 1055 +      
ENSG00000104381 E057 0.0000000       8 74450972 74451029 58 +      
ENSG00000104381 E058 3.4287420 0.0156340187 0.0007710988 0.003153968 8 74488678 74488879 202 + 0.418 0.935 2.235
ENSG00000104381 E059 2.0744087 0.0069899735 0.2325711296 0.365508883 8 74492052 74494159 2108 + 0.387 0.596 1.035
ENSG00000104381 E060 0.5975289 0.0300280038 0.3261353001 0.469579210 8 74494160 74494268 109 + 0.235 0.000 -13.518
ENSG00000104381 E061 0.4439371 0.0215713744 0.4903947256 0.627736926 8 74494269 74494697 429 + 0.187 0.000 -13.190
ENSG00000104381 E062 1.9125022 0.0124630708 0.0177057520 0.046499689 8 74496409 74500512 4104 + 0.523 0.000 -15.162
ENSG00000104381 E063 0.6633060 0.0230370190 0.9607763693 0.979308309 8 74500513 74500597 85 + 0.187 0.201 0.131
ENSG00000104381 E064 4.9414146 0.0032321459 0.0602873240 0.127100519 8 74501522 74504745 3224 + 0.645 0.907 1.050
ENSG00000104381 E065 0.2955422 0.0288255653 0.3865034344   8 74514459 74518007 3549 + 0.072 0.201 1.711