ENSG00000104369

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342232 ENSG00000104369 HEK293_OSMI2_2hA HEK293_TMG_2hB JPH1 protein_coding protein_coding 7.278695 4.825534 9.538245 0.4423977 0.4102419 0.9815603 3.9170415 4.125353147 4.460339 0.387231142 0.40183857 0.1123736 0.61707083 0.855266667 0.4729667 -0.38230000 4.284224e-06 2.97801e-09 FALSE TRUE
ENST00000518195 ENSG00000104369 HEK293_OSMI2_2hA HEK293_TMG_2hB JPH1 protein_coding processed_transcript 7.278695 4.825534 9.538245 0.4423977 0.4102419 0.9815603 0.4887529 0.000000000 0.000000 0.000000000 0.00000000 0.0000000 0.05075833 0.000000000 0.0000000 0.00000000   2.97801e-09 FALSE TRUE
MSTRG.31665.2 ENSG00000104369 HEK293_OSMI2_2hA HEK293_TMG_2hB JPH1 protein_coding   7.278695 4.825534 9.538245 0.4423977 0.4102419 0.9815603 0.8204354 0.425499656 1.055716 0.166771321 0.30245014 1.2910795 0.10199167 0.088200000 0.1087333 0.02053333 8.541198e-01 2.97801e-09 FALSE TRUE
MSTRG.31665.3 ENSG00000104369 HEK293_OSMI2_2hA HEK293_TMG_2hB JPH1 protein_coding   7.278695 4.825534 9.538245 0.4423977 0.4102419 0.9815603 0.9785956 0.224913704 2.019832 0.075340996 0.33497166 3.1111578 0.10979583 0.045500000 0.2107333 0.16523333 2.840266e-04 2.97801e-09 FALSE TRUE
MSTRG.31665.5 ENSG00000104369 HEK293_OSMI2_2hA HEK293_TMG_2hB JPH1 protein_coding   7.278695 4.825534 9.538245 0.4423977 0.4102419 0.9815603 0.5046870 0.008307206 1.025812 0.008307206 0.07286671 5.8222064 0.05476250 0.001466667 0.1085667 0.10710000 2.978010e-09 2.97801e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104369 E001 131.47840 0.0041286680 1.087914e-17 5.320137e-16 8 74234700 74235313 614 - 1.925 2.272 1.165
ENSG00000104369 E002 58.23505 0.0004376164 2.012376e-06 1.564634e-05 8 74235314 74235328 15 - 1.661 1.873 0.717
ENSG00000104369 E003 73.29802 0.0004200620 4.973451e-09 6.494385e-08 8 74235329 74235378 50 - 1.748 1.982 0.787
ENSG00000104369 E004 84.83976 0.0003614155 2.566314e-11 5.001858e-10 8 74235379 74235487 109 - 1.804 2.050 0.829
ENSG00000104369 E005 195.05067 0.0002756926 5.770884e-10 8.947350e-09 8 74235488 74236398 911 - 2.221 2.365 0.482
ENSG00000104369 E006 68.98416 0.0030960856 1.000808e-01 1.906045e-01 8 74236399 74236609 211 - 1.884 1.801 -0.280
ENSG00000104369 E007 43.21415 0.0010972775 8.140157e-01 8.821386e-01 8 74236610 74236755 146 - 1.655 1.639 -0.054
ENSG00000104369 E008 11.35744 0.0015990344 8.004239e-01 8.727836e-01 8 74236756 74236758 3 - 1.091 1.112 0.076
ENSG00000104369 E009 16.33217 0.0030643801 4.811901e-01 6.194324e-01 8 74236759 74236802 44 - 1.220 1.276 0.200
ENSG00000104369 E010 39.69937 0.0005801909 1.564061e-01 2.703339e-01 8 74236803 74237006 204 - 1.652 1.571 -0.278
ENSG00000104369 E011 20.84514 0.0009574538 1.485163e-01 2.596552e-01 8 74237007 74237035 29 - 1.390 1.277 -0.391
ENSG00000104369 E012 32.80458 0.0027678805 1.139627e-02 3.210966e-02 8 74237208 74237232 25 - 1.603 1.434 -0.580
ENSG00000104369 E013 40.01602 0.0027371220 1.117971e-01 2.081966e-01 8 74237233 74237303 71 - 1.655 1.554 -0.345
ENSG00000104369 E014 157.40538 0.0003206132 3.904074e-17 1.763087e-15 8 74244529 74245175 647 - 2.300 2.060 -0.802
ENSG00000104369 E015 42.96033 0.0055748737 1.047713e-04 5.440657e-04 8 74259385 74259503 119 - 1.750 1.489 -0.887
ENSG00000104369 E016 130.85082 0.0052312712 8.905362e-12 1.871015e-10 8 74314861 74315620 760 - 2.245 1.929 -1.058
ENSG00000104369 E017 49.02394 0.0041408330 4.590851e-08 4.988946e-07 8 74320909 74321273 365 - 1.828 1.490 -1.148
ENSG00000104369 E018 13.21399 0.0013436347 6.678317e-07 5.760539e-06 8 74321274 74321540 267 - 1.325 0.820 -1.843