ENSG00000104361

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341166 ENSG00000104361 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPAL2 protein_coding protein_coding 1.913156 0.5947688 2.919413 0.0638876 0.2454281 2.276156 0.06182625 0.09285629 0.1289001 0.007353484 0.12890006 0.4334172 0.04609583 0.1602667 0.05306667 -0.1072000 0.23582771 0.0111285 FALSE TRUE
ENST00000430223 ENSG00000104361 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPAL2 protein_coding protein_coding 1.913156 0.5947688 2.919413 0.0638876 0.2454281 2.276156 1.38285741 0.48723969 1.7526263 0.052177627 0.12323794 1.8257133 0.77212083 0.8193667 0.60233333 -0.2170333 0.04313835 0.0111285 FALSE TRUE
ENST00000520735 ENSG00000104361 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPAL2 protein_coding processed_transcript 1.913156 0.5947688 2.919413 0.0638876 0.2454281 2.276156 0.19032370 0.00000000 0.5192615 0.000000000 0.25971127 5.7259088 0.05928333 0.0000000 0.16410000 0.1641000 0.42355828 0.0111285 FALSE TRUE
ENST00000521820 ENSG00000104361 HEK293_OSMI2_2hA HEK293_TMG_2hB NIPAL2 protein_coding retained_intron 1.913156 0.5947688 2.919413 0.0638876 0.2454281 2.276156 0.20852091 0.00000000 0.4093268 0.000000000 0.07871759 5.3900033 0.09676250 0.0000000 0.14366667 0.1436667 0.01112850 0.0111285   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104361 E001 0.0000000       8 98189826 98189832 7 -      
ENSG00000104361 E002 82.1504616 0.0005353575 0.001524852 0.005717288 8 98189833 98192204 2372 - 1.855 1.947 0.310
ENSG00000104361 E003 17.6308409 0.0413304952 0.050065242 0.109278405 8 98192205 98192757 553 - 1.300 1.035 -0.946
ENSG00000104361 E004 15.8378959 0.0012673929 0.357806228 0.502215937 8 98192758 98193090 333 - 1.217 1.120 -0.346
ENSG00000104361 E005 2.1767175 0.0073212061 0.028684426 0.069374468 8 98193385 98193412 28 - 0.332 0.688 1.758
ENSG00000104361 E006 9.8647205 0.0278366985 0.164034255 0.280404219 8 98194728 98194822 95 - 0.946 1.103 0.575
ENSG00000104361 E007 1.9336067 0.0081237637 0.011988532 0.033505318 8 98195691 98195941 251 - 0.542 0.000 -12.651
ENSG00000104361 E008 8.2317085 0.0021187297 0.537366203 0.668934166 8 98195942 98196005 64 - 0.907 0.969 0.232
ENSG00000104361 E009 8.8001177 0.0022915455 0.374577235 0.519008382 8 98203108 98203196 89 - 0.927 1.018 0.336
ENSG00000104361 E010 9.7672607 0.0019121334 0.961698620 0.979858546 8 98205111 98205246 136 - 0.999 0.994 -0.020
ENSG00000104361 E011 6.4707007 0.0027065665 0.572695072 0.698770905 8 98212405 98212501 97 - 0.864 0.777 -0.340
ENSG00000104361 E012 0.0000000       8 98217025 98217038 14 -      
ENSG00000104361 E013 0.7405115 0.2381151003 0.284695064 0.424946429 8 98217039 98217198 160 - 0.291 0.000 -11.080
ENSG00000104361 E014 0.2944980 0.2644039139 0.835955099   8 98217199 98217202 4 - 0.141 0.000 -9.772
ENSG00000104361 E015 0.4417471 0.5879763878 0.737953016 0.827966580 8 98217203 98217262 60 - 0.197 0.000 -9.742
ENSG00000104361 E016 0.0000000       8 98217263 98217286 24 -      
ENSG00000104361 E017 12.3510867 0.0015600372 0.021879957 0.055426785 8 98222479 98222600 122 - 1.152 0.883 -0.989
ENSG00000104361 E018 0.0000000       8 98231781 98231855 75 -      
ENSG00000104361 E019 9.5163817 0.0018242322 0.161001729 0.276425065 8 98236155 98236214 60 - 1.031 0.851 -0.678
ENSG00000104361 E020 0.0000000       8 98236215 98236231 17 -      
ENSG00000104361 E021 0.0000000       8 98251608 98251754 147 -      
ENSG00000104361 E022 1.2458827 0.0124678096 0.028019589 0.068053321 8 98252197 98252462 266 - 0.197 0.576 2.269
ENSG00000104361 E023 11.6596891 0.0015928410 0.437760059 0.579650457 8 98252463 98252634 172 - 1.089 0.994 -0.348
ENSG00000104361 E024 6.1916178 0.0029152081 0.445733346 0.587277328 8 98254019 98254087 69 - 0.852 0.735 -0.465
ENSG00000104361 E025 6.9560893 0.0034083248 0.421147037 0.564278590 8 98294003 98294393 391 - 0.897 0.777 -0.465