ENSG00000104290

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000523546 ENSG00000104290 HEK293_OSMI2_2hA HEK293_TMG_2hB FZD3 protein_coding protein_coding 4.25356 1.748474 4.706082 0.2180822 0.2977278 1.423265 0.3417255 0.0000000 0.2556675 0.0000000 0.25566746 4.7315496 0.05144583 0.00000000 0.0491000 0.04910000 9.659691e-01 1.044761e-05 FALSE FALSE
ENST00000537916 ENSG00000104290 HEK293_OSMI2_2hA HEK293_TMG_2hB FZD3 protein_coding protein_coding 4.25356 1.748474 4.706082 0.2180822 0.2977278 1.423265 0.6563814 0.1012535 1.1220368 0.1012535 0.22360465 3.3469981 0.12323333 0.04666667 0.2437000 0.19703333 1.417539e-01 1.044761e-05 FALSE TRUE
MSTRG.31323.4 ENSG00000104290 HEK293_OSMI2_2hA HEK293_TMG_2hB FZD3 protein_coding   4.25356 1.748474 4.706082 0.2180822 0.2977278 1.423265 2.6973737 1.5209793 2.6076158 0.1768975 0.10964704 0.7737985 0.71080000 0.87173333 0.5575333 -0.31420000 1.044761e-05 1.044761e-05 TRUE TRUE
MSTRG.31323.5 ENSG00000104290 HEK293_OSMI2_2hA HEK293_TMG_2hB FZD3 protein_coding   4.25356 1.748474 4.706082 0.2180822 0.2977278 1.423265 0.3957823 0.0431204 0.5422562 0.0431204 0.08097134 3.3779998 0.07215833 0.02636667 0.1151333 0.08876667 1.032249e-01 1.044761e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104290 E001 0.1451727 0.0442139646 1.000000e+00   8 28494205 28494211 7 + 0.070 0.000 -8.927
ENSG00000104290 E002 0.1451727 0.0442139646 1.000000e+00   8 28494212 28494213 2 + 0.070 0.000 -9.149
ENSG00000104290 E003 0.2903454 0.3510523052 1.000000e+00   8 28494214 28494224 11 + 0.131 0.000 -10.275
ENSG00000104290 E004 0.2924217 0.0276715029 1.000000e+00   8 28494225 28494226 2 + 0.131 0.000 -10.127
ENSG00000104290 E005 10.8628005 0.0016674778 1.292664e-01 2.331677e-01 8 28494227 28494343 117 + 0.991 1.134 0.519
ENSG00000104290 E006 7.7071453 0.0022260089 1.799656e-01 3.011434e-01 8 28499933 28499978 46 + 0.855 1.001 0.549
ENSG00000104290 E007 70.8023948 0.0004121048 7.778345e-08 8.068244e-07 8 28502670 28503202 533 + 1.739 1.945 0.694
ENSG00000104290 E008 52.2283800 0.0004843663 1.113866e-09 1.637072e-08 8 28520638 28520834 197 + 1.584 1.861 0.938
ENSG00000104290 E009 98.0525332 0.0003365848 3.807734e-16 1.519300e-14 8 28527147 28528164 1018 + 1.862 2.121 0.866
ENSG00000104290 E010 0.4386386 0.1104378825 6.378797e-01 7.516648e-01 8 28536893 28536944 52 + 0.131 0.203 0.764
ENSG00000104290 E011 12.6836076 0.0131626806 5.599470e-03 1.755163e-02 8 28551603 28551751 149 + 1.163 0.763 -1.498
ENSG00000104290 E012 0.4417471 0.7555287393 1.000000e+00 1.000000e+00 8 28554168 28554256 89 + 0.184 0.000 -10.892
ENSG00000104290 E013 20.5585449 0.0031301048 8.557302e-05 4.543469e-04 8 28555738 28555971 234 + 1.359 0.915 -1.597
ENSG00000104290 E014 20.3537710 0.0010112702 1.318348e-02 3.633941e-02 8 28562798 28563062 265 + 1.331 1.073 -0.916
ENSG00000104290 E015 12.9594559 0.0014846307 6.792678e-04 2.823267e-03 8 28563063 28563266 204 + 1.174 0.717 -1.725
ENSG00000104290 E016 30.5155278 0.0016954263 3.477657e-04 1.571266e-03 8 28563267 28563940 674 + 1.507 1.189 -1.110
ENSG00000104290 E017 65.5872157 0.0003740121 3.472182e-18 1.789430e-16 8 28563941 28567076 3136 + 1.860 1.293 -1.939
ENSG00000104290 E018 51.4048269 0.0297100142 2.623857e-02 6.443391e-02 8 28567077 28570350 3274 + 1.715 1.503 -0.724
ENSG00000104290 E019 92.1720976 0.0094755137 2.475904e-02 6.138067e-02 8 28570351 28574267 3917 + 1.952 1.804 -0.497