ENSG00000104231

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000220669 ENSG00000104231 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND1 protein_coding protein_coding 25.91078 8.025983 46.47287 1.217985 0.7008215 2.532153 0.8803512 1.18275953 1.895296 0.37608048 0.17847535 0.6757122 0.041137500 0.146133333 0.04080000 -0.10533333 3.388457e-03 2.512133e-10 FALSE TRUE
ENST00000519523 ENSG00000104231 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND1 protein_coding protein_coding 25.91078 8.025983 46.47287 1.217985 0.7008215 2.532153 4.3108184 0.39683650 6.933688 0.39683650 1.21115461 4.0931810 0.137170833 0.038600000 0.14886667 0.11026667 1.588054e-01 2.512133e-10 FALSE TRUE
ENST00000520604 ENSG00000104231 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND1 protein_coding protein_coding 25.91078 8.025983 46.47287 1.217985 0.7008215 2.532153 0.9707559 0.02487417 2.636314 0.02487417 0.02022723 6.2456817 0.031825000 0.004066667 0.05673333 0.05266667 2.512133e-10 2.512133e-10   FALSE
ENST00000521287 ENSG00000104231 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND1 protein_coding protein_coding 25.91078 8.025983 46.47287 1.217985 0.7008215 2.532153 4.2495598 0.72077103 7.538115 0.31775822 0.62765058 3.3686251 0.140608333 0.088133333 0.16213333 0.07400000 3.300486e-01 2.512133e-10 FALSE TRUE
ENST00000522520 ENSG00000104231 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND1 protein_coding protein_coding 25.91078 8.025983 46.47287 1.217985 0.7008215 2.532153 6.6610494 3.23655540 10.052580 0.32738307 0.86171186 1.6320185 0.272416667 0.429933333 0.21586667 -0.21406667 1.410617e-01 2.512133e-10 FALSE TRUE
ENST00000523096 ENSG00000104231 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND1 protein_coding protein_coding 25.91078 8.025983 46.47287 1.217985 0.7008215 2.532153 2.8701636 1.16360604 5.257594 0.66969762 0.27386729 2.1661960 0.136387500 0.125933333 0.11316667 -0.01276667 9.180565e-01 2.512133e-10 FALSE TRUE
ENST00000524305 ENSG00000104231 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND1 protein_coding retained_intron 25.91078 8.025983 46.47287 1.217985 0.7008215 2.532153 1.4401830 0.27035749 2.012713 0.11418188 0.32779010 2.8509518 0.070133333 0.031300000 0.04316667 0.01186667 7.235981e-01 2.512133e-10 FALSE FALSE
MSTRG.31740.1 ENSG00000104231 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFAND1 protein_coding   25.91078 8.025983 46.47287 1.217985 0.7008215 2.532153 0.3531825 0.00000000 2.619783 0.00000000 1.48620808 8.0388000 0.007729167 0.000000000 0.05646667 0.05646667 3.911964e-01 2.512133e-10 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104231 E001 2.0776455 0.0080568103 9.356388e-01 9.634990e-01 8 81698272 81698336 65 - 0.446 0.470 0.122
ENSG00000104231 E002 0.2934659 0.0279781038 3.181961e-01   8 81701334 81701336 3 - 0.065 0.217 1.997
ENSG00000104231 E003 18.3091864 0.0010912905 3.849025e-02 8.826331e-02 8 81701337 81701721 385 - 1.171 1.364 0.676
ENSG00000104231 E004 22.8419733 0.0053076437 1.271426e-04 6.463129e-04 8 81701722 81701764 43 - 1.217 1.547 1.147
ENSG00000104231 E005 157.0689098 0.0045700616 1.557638e-08 1.851950e-07 8 81701765 81702158 394 - 2.057 2.310 0.849
ENSG00000104231 E006 108.5211645 0.0045981695 4.790949e-04 2.079862e-03 8 81702159 81702323 165 - 1.922 2.101 0.598
ENSG00000104231 E007 113.0965904 0.0021232836 1.520539e-04 7.560522e-04 8 81702324 81702543 220 - 1.943 2.113 0.572
ENSG00000104231 E008 19.0848412 0.0009675150 1.004940e-03 3.975419e-03 8 81702544 81702547 4 - 1.157 1.442 0.998
ENSG00000104231 E009 75.9103333 0.0003693502 9.664139e-04 3.843400e-03 8 81702548 81702681 134 - 1.775 1.935 0.540
ENSG00000104231 E010 57.5667061 0.0013987481 2.411059e-02 6.004001e-02 8 81702682 81702728 47 - 1.665 1.797 0.448
ENSG00000104231 E011 80.6917078 0.0003590426 3.219943e-01 4.652647e-01 8 81702729 81702768 40 - 1.851 1.815 -0.120
ENSG00000104231 E012 103.4994393 0.0006007946 5.884792e-02 1.246569e-01 8 81702769 81702824 56 - 1.965 1.894 -0.239
ENSG00000104231 E013 97.3482655 0.0003598068 7.901813e-01 8.657953e-01 8 81702825 81702857 33 - 1.923 1.922 -0.001
ENSG00000104231 E014 65.5565204 0.0004001750 9.523434e-01 9.741513e-01 8 81702858 81702865 8 - 1.752 1.760 0.028
ENSG00000104231 E015 2.5560260 0.0059973416 3.481803e-01 4.924058e-01 8 81702866 81702889 24 - 0.537 0.362 -0.908
ENSG00000104231 E016 0.7383454 0.2804195283 4.110556e-02 9.308079e-02 8 81702914 81702968 55 - 0.065 0.542 3.932
ENSG00000104231 E017 91.0574770 0.0010015603 1.513558e-01 2.635106e-01 8 81702969 81702992 24 - 1.906 1.849 -0.194
ENSG00000104231 E018 141.8937539 0.0021412790 2.424512e-01 3.770452e-01 8 81702993 81703087 95 - 2.095 2.056 -0.130
ENSG00000104231 E019 73.5198907 0.0010243629 7.091618e-01 8.066222e-01 8 81703088 81703098 11 - 1.806 1.798 -0.029
ENSG00000104231 E020 66.9081423 0.0011858502 7.873634e-01 8.638203e-01 8 81703099 81703103 5 - 1.764 1.760 -0.015
ENSG00000104231 E021 70.9923550 0.0007734476 9.134209e-01 9.491323e-01 8 81703104 81703124 21 - 1.786 1.802 0.055
ENSG00000104231 E022 1.6240402 0.0085464277 8.796474e-04 3.542656e-03 8 81703125 81703128 4 - 0.173 0.744 3.220
ENSG00000104231 E023 3.5339155 0.1892209595 8.675812e-01 9.188429e-01 8 81708788 81708829 42 - 0.614 0.556 -0.262
ENSG00000104231 E024 91.3595483 0.0002823824 8.174281e-01 8.845559e-01 8 81713918 81713947 30 - 1.897 1.898 0.004
ENSG00000104231 E025 70.9445718 0.0003362376 9.897108e-01 9.976309e-01 8 81713948 81713950 3 - 1.786 1.798 0.041
ENSG00000104231 E026 139.0491150 0.0002677316 7.319533e-02 1.486334e-01 8 81713951 81714039 89 - 2.088 2.035 -0.180
ENSG00000104231 E027 15.2042062 0.0011797903 1.496315e-01 2.611743e-01 8 81714040 81714324 285 - 1.176 1.032 -0.521
ENSG00000104231 E028 13.3436298 0.0075285216 1.037038e-02 2.967328e-02 8 81714325 81714439 115 - 1.152 0.835 -1.176
ENSG00000104231 E029 15.8654373 0.0012269885 9.463815e-02 1.823362e-01 8 81714440 81714598 159 - 1.199 1.032 -0.603
ENSG00000104231 E030 12.4989686 0.0013859111 2.673792e-01 4.056878e-01 8 81714599 81714673 75 - 1.093 0.976 -0.431
ENSG00000104231 E031 13.2650519 0.0020388141 1.131684e-01 2.101492e-01 8 81714674 81714803 130 - 1.121 0.945 -0.645
ENSG00000104231 E032 157.0706900 0.0010905597 2.216632e-02 5.602112e-02 8 81714804 81714895 92 - 2.144 2.069 -0.251
ENSG00000104231 E033 4.7711386 0.0686610967 3.553245e-01 4.996797e-01 8 81714896 81714918 23 - 0.661 0.832 0.693
ENSG00000104231 E034 2.6819655 0.0490293154 7.651794e-02 1.539239e-01 8 81714919 81714986 68 - 0.419 0.744 1.481
ENSG00000104231 E035 166.5485044 0.0008391283 1.083447e-02 3.076836e-02 8 81714987 81715114 128 - 2.171 2.090 -0.269
ENSG00000104231 E036 39.8290434 0.0005558252 7.012005e-03 2.125482e-02 8 81717249 81717251 3 - 1.579 1.399 -0.619
ENSG00000104231 E037 53.0050498 0.0005238354 1.054456e-03 4.147828e-03 8 81717252 81717288 37 - 1.702 1.508 -0.660
ENSG00000104231 E038 97.8217990 0.0003307811 5.141892e-04 2.212442e-03 8 81718182 81718224 43 - 1.954 1.807 -0.494
ENSG00000104231 E039 2.2049239 0.0131556722 1.918431e-02 4.973795e-02 8 81720752 81721065 314 - 0.537 0.000 -11.874
ENSG00000104231 E040 0.2944980 0.4289415054 1.000000e+00   8 81721066 81721069 4 - 0.122 0.000 -9.041
ENSG00000104231 E041 1.5791792 0.0183699850 9.828452e-01 9.933319e-01 8 81721070 81721226 157 - 0.362 0.362 0.002
ENSG00000104231 E042 61.1100365 0.0024881119 1.178398e-01 2.168367e-01 8 81721227 81721248 22 - 1.741 1.655 -0.289
ENSG00000104231 E043 61.5517341 0.0029993687 7.123249e-02 1.453842e-01 8 81721249 81721300 52 - 1.747 1.643 -0.353
ENSG00000104231 E044 21.6475476 0.0008842653 1.649991e-06 1.306687e-05 8 81732199 81732619 421 - 1.364 0.836 -1.919
ENSG00000104231 E045 2.7689515 0.1642030408 7.691064e-01 8.508266e-01 8 81732753 81732903 151 - 0.537 0.472 -0.317