ENSG00000104219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262096 ENSG00000104219 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC2 protein_coding protein_coding 7.880612 5.587691 11.38654 1.149916 0.9362022 1.025692 1.607462 0.3987374 4.476240 0.05181949 0.2151503 3.4562605 0.2073875 0.08063333 0.4003667 0.31973333 2.485167e-05 1.602304e-22 FALSE TRUE
ENST00000522184 ENSG00000104219 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC2 protein_coding protein_coding 7.880612 5.587691 11.38654 1.149916 0.9362022 1.025692 4.766167 3.6626669 6.444719 0.82109797 1.0700464 0.8135263 0.6150417 0.65023333 0.5583000 -0.09193333 4.685762e-01 1.602304e-22 FALSE FALSE
MSTRG.31206.2 ENSG00000104219 HEK293_OSMI2_2hA HEK293_TMG_2hB ZDHHC2 protein_coding   7.880612 5.587691 11.38654 1.149916 0.9362022 1.025692 1.100785 1.2429818 0.000000 0.17321297 0.0000000 -6.9692217 0.1295125 0.23066667 0.0000000 -0.23066667 1.602304e-22 1.602304e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104219 E001 3.5964479 0.0051369762 3.425451e-04 1.550481e-03 8 17156482 17156511 30 + 0.818 0.157 -3.674
ENSG00000104219 E002 3.8899137 0.0039980274 1.452462e-03 5.481802e-03 8 17156512 17156513 2 + 0.834 0.273 -2.736
ENSG00000104219 E003 7.3745990 0.0024101769 1.043826e-04 5.421959e-04 8 17156514 17156597 84 + 1.067 0.503 -2.289
ENSG00000104219 E004 5.8902280 0.0027712274 5.528770e-04 2.357489e-03 8 17156598 17156686 89 + 0.977 0.439 -2.280
ENSG00000104219 E005 3.1118369 0.0097955384 5.807815e-02 1.233412e-01 8 17156687 17156698 12 + 0.710 0.364 -1.652
ENSG00000104219 E006 29.7238312 0.0007311178 1.157243e-01 2.138493e-01 8 17156699 17156853 155 + 1.528 1.398 -0.447
ENSG00000104219 E007 0.1482932 0.0406018585 2.566538e-01   8 17157434 17157573 140 + 0.000 0.157 10.640
ENSG00000104219 E008 0.0000000       8 17162799 17162889 91 +      
ENSG00000104219 E009 30.9481784 0.0006519337 5.494054e-01 6.791371e-01 8 17184789 17184815 27 + 1.525 1.462 -0.218
ENSG00000104219 E010 58.8415763 0.0004702354 4.173653e-01 5.607265e-01 8 17186331 17186425 95 + 1.795 1.731 -0.215
ENSG00000104219 E011 1.7608730 0.0109092991 3.186560e-03 1.081619e-02 8 17189880 17189914 35 + 0.592 0.000 -12.804
ENSG00000104219 E012 75.0744944 0.0065022731 9.853936e-01 9.949015e-01 8 17195504 17195624 121 + 1.886 1.862 -0.079
ENSG00000104219 E013 66.9856634 0.0004936300 2.026353e-01 3.295106e-01 8 17197582 17197651 70 + 1.818 1.847 0.100
ENSG00000104219 E014 48.9162059 0.0004970719 1.661005e-02 4.408042e-02 8 17198381 17198413 33 + 1.654 1.748 0.318
ENSG00000104219 E015 75.3722632 0.0003557541 2.673729e-02 6.544568e-02 8 17205655 17205775 121 + 1.852 1.915 0.213
ENSG00000104219 E016 51.2573274 0.0004698936 3.786056e-02 8.708695e-02 8 17207960 17208012 53 + 1.679 1.755 0.257
ENSG00000104219 E017 28.1714293 0.0007522992 5.790103e-02 1.230335e-01 8 17208013 17208017 5 + 1.419 1.517 0.338
ENSG00000104219 E018 65.2711855 0.0004110584 2.144166e-01 3.437702e-01 8 17208018 17208092 75 + 1.803 1.831 0.095
ENSG00000104219 E019 110.7172429 0.0004494779 7.131521e-03 2.156531e-02 8 17209932 17210058 127 + 2.016 2.080 0.213
ENSG00000104219 E020 0.0000000       8 17210059 17210185 127 +      
ENSG00000104219 E021 96.3109064 0.0033699859 1.778240e-04 8.688356e-04 8 17210388 17210480 93 + 1.924 2.056 0.445
ENSG00000104219 E022 96.6100199 0.0002851076 2.660745e-05 1.602563e-04 8 17215237 17215349 113 + 1.933 2.054 0.407
ENSG00000104219 E023 59.7361620 0.0004702723 3.074023e-06 2.294037e-05 8 17217172 17217246 75 + 1.692 1.876 0.622
ENSG00000104219 E024 237.7877869 0.0039561697 2.848423e-18 1.481673e-16 8 17220256 17224799 4544 + 2.476 2.142 -1.114