ENSG00000104177

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267836 ENSG00000104177 HEK293_OSMI2_2hA HEK293_TMG_2hB MYEF2 protein_coding protein_coding 9.243502 4.068347 14.0426 0.2164771 0.8198756 1.784781 2.31523447 1.1464605 3.3953429 0.06960121 0.05783472 1.55808409 0.262804167 0.28456667 0.2434667 -0.04110000 6.671681e-01 4.764078e-10 FALSE TRUE
ENST00000558395 ENSG00000104177 HEK293_OSMI2_2hA HEK293_TMG_2hB MYEF2 protein_coding protein_coding 9.243502 4.068347 14.0426 0.2164771 0.8198756 1.784781 2.04686188 0.4041159 3.3674015 0.20984701 0.55856297 3.02780734 0.174929167 0.09726667 0.2440333 0.14676667 4.597170e-01 4.764078e-10 FALSE TRUE
ENST00000560157 ENSG00000104177 HEK293_OSMI2_2hA HEK293_TMG_2hB MYEF2 protein_coding processed_transcript 9.243502 4.068347 14.0426 0.2164771 0.8198756 1.784781 0.34900380 0.3265841 0.3115569 0.15154792 0.15954063 -0.06589294 0.050337500 0.08170000 0.0229000 -0.05880000 4.228537e-01 4.764078e-10   FALSE
ENST00000616409 ENSG00000104177 HEK293_OSMI2_2hA HEK293_TMG_2hB MYEF2 protein_coding protein_coding 9.243502 4.068347 14.0426 0.2164771 0.8198756 1.784781 0.86786957 0.0000000 1.4413906 0.00000000 0.16422350 7.18129200 0.071850000 0.00000000 0.1024000 0.10240000 4.764078e-10 4.764078e-10 FALSE TRUE
ENST00000620867 ENSG00000104177 HEK293_OSMI2_2hA HEK293_TMG_2hB MYEF2 protein_coding protein_coding 9.243502 4.068347 14.0426 0.2164771 0.8198756 1.784781 0.03795259 0.3036208 0.0000000 0.30362075 0.00000000 -4.97094913 0.008454167 0.06763333 0.0000000 -0.06763333 6.059601e-01 4.764078e-10 FALSE TRUE
MSTRG.10745.18 ENSG00000104177 HEK293_OSMI2_2hA HEK293_TMG_2hB MYEF2 protein_coding   9.243502 4.068347 14.0426 0.2164771 0.8198756 1.784781 1.00495106 0.6549405 1.8184500 0.23697051 0.53278870 1.45932395 0.114566667 0.16193333 0.1258000 -0.03613333 9.262815e-01 4.764078e-10 FALSE TRUE
MSTRG.10745.2 ENSG00000104177 HEK293_OSMI2_2hA HEK293_TMG_2hB MYEF2 protein_coding   9.243502 4.068347 14.0426 0.2164771 0.8198756 1.784781 0.93780904 0.6876526 1.4206176 0.07147828 0.13913351 1.03605729 0.118054167 0.16953333 0.1010667 -0.06846667 7.499747e-02 4.764078e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104177 E001 38.2891892 0.0041596121 1.521871e-01 2.646636e-01 15 48134632 48139431 4800 - 1.585 1.487 -0.334
ENSG00000104177 E002 94.0741852 0.0075852998 3.607584e-01 5.051114e-01 15 48139432 48141795 2364 - 1.925 1.980 0.186
ENSG00000104177 E003 0.7353121 0.0875169494 3.250456e-01 4.684794e-01 15 48141796 48141796 1 - 0.141 0.326 1.540
ENSG00000104177 E004 0.5880631 0.2800406577 1.997962e-01 3.259851e-01 15 48141797 48141797 1 - 0.076 0.331 2.575
ENSG00000104177 E005 0.5880631 0.2800406577 1.997962e-01 3.259851e-01 15 48141798 48141805 8 - 0.076 0.331 2.575
ENSG00000104177 E006 29.7712016 0.0032294478 4.585766e-03 1.478085e-02 15 48141806 48142082 277 - 1.385 1.585 0.687
ENSG00000104177 E007 25.8185734 0.0008062152 1.259327e-02 3.495410e-02 15 48142083 48142136 54 - 1.333 1.511 0.613
ENSG00000104177 E008 61.1652045 0.0004697700 1.492923e-09 2.142975e-08 15 48142137 48142651 515 - 1.647 1.926 0.941
ENSG00000104177 E009 11.4057765 0.0018137790 7.606744e-04 3.117671e-03 15 48142652 48142665 14 - 0.919 1.258 1.229
ENSG00000104177 E010 25.1866759 0.0101383131 2.099497e-05 1.296003e-04 15 48142666 48142857 192 - 1.234 1.589 1.229
ENSG00000104177 E011 18.5740154 0.0035820405 7.477107e-02 1.511643e-01 15 48142858 48142895 38 - 1.198 1.353 0.543
ENSG00000104177 E012 41.5865282 0.0023996681 8.926693e-01 9.354193e-01 15 48142896 48143060 165 - 1.587 1.580 -0.024
ENSG00000104177 E013 20.3600533 0.0011104448 1.175764e-01 2.164863e-01 15 48143061 48143071 11 - 1.322 1.186 -0.477
ENSG00000104177 E014 24.5611759 0.0057069747 1.295287e-01 2.335074e-01 15 48149032 48149083 52 - 1.401 1.271 -0.453
ENSG00000104177 E015 0.1451727 0.0425837567 1.000000e+00   15 48149084 48149162 79 - 0.076 0.000 -9.564
ENSG00000104177 E016 29.0103651 0.0007615111 6.254420e-01 7.415648e-01 15 48149163 48149196 34 - 1.445 1.412 -0.115
ENSG00000104177 E017 65.8298888 0.0003761842 2.181644e-01 3.482042e-01 15 48149197 48149371 175 - 1.802 1.745 -0.193
ENSG00000104177 E018 1.3338878 0.0096403514 3.997098e-02 9.097813e-02 15 48149372 48149986 615 - 0.436 0.000 -12.735
ENSG00000104177 E019 18.3609315 0.0010467935 7.438010e-01 8.323386e-01 15 48151100 48151171 72 - 1.257 1.230 -0.096
ENSG00000104177 E020 52.8566942 0.0004968009 4.183081e-02 9.441724e-02 15 48151473 48151571 99 - 1.725 1.615 -0.371
ENSG00000104177 E021 48.9313082 0.0004951159 9.649028e-01 9.818925e-01 15 48151874 48151942 69 - 1.660 1.660 -0.003
ENSG00000104177 E022 1.3391983 0.0104416957 2.743542e-01 4.134957e-01 15 48151943 48152116 174 - 0.404 0.191 -1.479
ENSG00000104177 E023 0.5954526 0.0172671820 2.606572e-01 3.982220e-01 15 48152117 48152233 117 - 0.248 0.000 -11.565
ENSG00000104177 E024 24.7881555 0.0033534830 3.437140e-01 4.877682e-01 15 48152234 48152284 51 - 1.395 1.319 -0.262
ENSG00000104177 E025 3.8522242 0.0428139166 4.431832e-04 1.940547e-03 15 48152307 48153791 1485 - 0.778 0.000 -14.266
ENSG00000104177 E026 45.3854175 0.0004894274 5.549905e-01 6.838946e-01 15 48153792 48153893 102 - 1.636 1.604 -0.110
ENSG00000104177 E027 0.7405235 0.0163712245 4.996395e-01 6.359271e-01 15 48153894 48154076 183 - 0.198 0.322 0.934
ENSG00000104177 E028 7.0827529 0.0116765907 4.792190e-01 6.176043e-01 15 48157136 48157898 763 - 0.909 0.813 -0.371
ENSG00000104177 E029 32.5281386 0.0006560523 4.515051e-02 1.004691e-01 15 48157993 48158056 64 - 1.522 1.383 -0.478
ENSG00000104177 E030 31.5847700 0.0009247593 4.420764e-02 9.877234e-02 15 48158175 48158224 50 - 1.514 1.373 -0.488
ENSG00000104177 E031 51.3786689 0.0004416811 1.822265e-02 4.761822e-02 15 48158769 48158922 154 - 1.715 1.585 -0.441
ENSG00000104177 E032 0.0000000       15 48159596 48159612 17 -      
ENSG00000104177 E033 50.3565985 0.0005210285 9.304601e-03 2.704318e-02 15 48159613 48159804 192 - 1.712 1.566 -0.495
ENSG00000104177 E034 4.6605193 0.0036630298 3.046472e-02 7.287368e-02 15 48162695 48162711 17 - 0.610 0.912 1.222
ENSG00000104177 E035 4.0307132 0.0041219599 1.298656e-01 2.339744e-01 15 48162712 48162718 7 - 0.589 0.814 0.937
ENSG00000104177 E036 10.6106752 0.0016427476 6.887839e-05 3.746319e-04 15 48162719 48162893 175 - 0.866 1.271 1.477
ENSG00000104177 E037 35.9528343 0.0109857401 7.450290e-01 8.331819e-01 15 48165933 48166026 94 - 1.522 1.547 0.087
ENSG00000104177 E038 0.0000000       15 48166027 48166027 1 -      
ENSG00000104177 E039 21.0983318 0.0032107980 6.920375e-01 7.933510e-01 15 48166121 48166128 8 - 1.297 1.331 0.117
ENSG00000104177 E040 0.3686942 0.0280291825 4.414802e-01 5.831214e-01 15 48167342 48167348 7 - 0.076 0.191 1.525
ENSG00000104177 E041 36.6993026 0.0005617496 4.427024e-01 5.842835e-01 15 48167349 48167401 53 - 1.551 1.504 -0.163
ENSG00000104177 E042 49.7189830 0.0008350247 1.307268e-02 3.607965e-02 15 48168631 48168839 209 - 1.702 1.560 -0.483
ENSG00000104177 E043 0.0000000       15 48169845 48169910 66 -      
ENSG00000104177 E044 20.2192138 0.0048441558 1.275104e-03 4.894232e-03 15 48178077 48178353 277 - 1.359 1.039 -1.138