ENSG00000104131

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261868 ENSG00000104131 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3J protein_coding protein_coding 55.24827 33.50373 83.18008 0.639855 3.455253 1.311659 23.015826 17.757281 34.506035 0.5643524 1.582102 0.958043815 0.4291167 0.5304333 0.41480000 -0.11563333 0.001491224 0.001491224 FALSE TRUE
ENST00000558353 ENSG00000104131 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3J protein_coding nonsense_mediated_decay 55.24827 33.50373 83.18008 0.639855 3.455253 1.311659 4.365685 3.661995 3.680567 0.2552753 3.680567 0.007278268 0.0792375 0.1092667 0.04223333 -0.06703333 0.122255996 0.001491224 TRUE FALSE
MSTRG.10682.1 ENSG00000104131 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3J protein_coding   55.24827 33.50373 83.18008 0.639855 3.455253 1.311659 20.849330 9.119021 33.657131 1.0729057 1.614631 1.882808749 0.3573250 0.2724000 0.40443333 0.13203333 0.032663561 0.001491224 TRUE TRUE
MSTRG.10682.2 ENSG00000104131 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF3J protein_coding   55.24827 33.50373 83.18008 0.639855 3.455253 1.311659 1.892668 0.000000 7.018264 0.0000000 3.703918 9.457024641 0.0331250 0.0000000 0.08573333 0.08573333 0.249157504 0.001491224 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104131 E001 0.8900644 0.0533706454 7.817826e-02 1.565375e-01 15 44537057 44537059 3 + 0.357 0.000 -10.519
ENSG00000104131 E002 30.0361074 0.0006926282 4.463169e-01 5.878214e-01 15 44537060 44537124 65 + 1.479 1.453 -0.091
ENSG00000104131 E003 66.0959410 0.0011529859 3.182892e-01 4.612620e-01 15 44537125 44537146 22 + 1.810 1.787 -0.078
ENSG00000104131 E004 107.3015612 0.0027981107 3.666817e-04 1.645352e-03 15 44537147 44537182 36 + 2.053 1.917 -0.457
ENSG00000104131 E005 177.7608295 0.0045700627 7.811595e-05 4.190642e-04 15 44537183 44537237 55 + 2.274 2.125 -0.496
ENSG00000104131 E006 283.7943438 0.0020677626 1.620907e-08 1.921988e-07 15 44537324 44537427 104 + 2.478 2.324 -0.513
ENSG00000104131 E007 0.0000000       15 44550683 44550875 193 +      
ENSG00000104131 E008 239.0856380 0.0054284585 8.914362e-05 4.710080e-04 15 44550876 44550930 55 + 2.402 2.253 -0.496
ENSG00000104131 E009 154.9419233 0.0145350414 2.413869e-02 6.009912e-02 15 44551431 44551437 7 + 2.209 2.079 -0.438
ENSG00000104131 E010 265.7272200 0.0058947967 6.763441e-03 2.060884e-02 15 44551438 44551522 85 + 2.432 2.337 -0.315
ENSG00000104131 E011 282.4904057 0.0008464901 1.482520e-02 4.009864e-02 15 44554553 44554623 71 + 2.441 2.403 -0.126
ENSG00000104131 E012 279.0695555 0.0003544473 6.488360e-02 1.348458e-01 15 44554624 44554667 44 + 2.430 2.412 -0.059
ENSG00000104131 E013 199.5084279 0.0007469231 7.606358e-01 8.446570e-01 15 44557489 44557504 16 + 2.271 2.288 0.058
ENSG00000104131 E014 504.2148103 0.0001388535 6.314489e-01 7.464548e-01 15 44557505 44557650 146 + 2.668 2.701 0.113
ENSG00000104131 E015 1.4653388 0.1156854777 1.045509e-01 1.974387e-01 15 44557651 44557751 101 + 0.214 0.550 2.000
ENSG00000104131 E016 446.6081927 0.0016397106 4.692464e-01 6.085082e-01 15 44560249 44560322 74 + 2.611 2.655 0.146
ENSG00000104131 E017 4.9042175 0.0774084937 8.985179e-01 9.392827e-01 15 44560323 44560575 253 + 0.739 0.775 0.146
ENSG00000104131 E018 1500.8341839 0.0020056772 1.771390e-03 6.508369e-03 15 44561018 44561742 725 + 3.123 3.207 0.277
ENSG00000104131 E019 705.0354430 0.0043173476 2.146223e-07 2.045043e-06 15 44561743 44562803 1061 + 2.752 2.942 0.631
ENSG00000104131 E020 18.3469999 0.0046704125 7.973469e-01 8.706790e-01 15 44562811 44562916 106 + 1.251 1.299 0.167
ENSG00000104131 E021 78.3823468 0.0024259407 4.743444e-01 6.131953e-01 15 44562951 44563378 428 + 1.880 1.870 -0.034