ENSG00000104093

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000558124 ENSG00000104093 HEK293_OSMI2_2hA HEK293_TMG_2hB DMXL2 protein_coding processed_transcript 5.463978 2.824399 6.606313 0.3618859 0.3239563 1.222985 0.8458979 0.29548396 1.2153349 0.20030320 0.15012630 2.004008 0.13704167 0.103400000 0.1831333 0.07973333 5.927527e-01 7.545437e-16 FALSE FALSE
ENST00000559059 ENSG00000104093 HEK293_OSMI2_2hA HEK293_TMG_2hB DMXL2 protein_coding processed_transcript 5.463978 2.824399 6.606313 0.3618859 0.3239563 1.222985 0.4945955 0.52509838 0.0000000 0.13873192 0.00000000 -5.741732 0.08990833 0.187033333 0.0000000 -0.18703333 7.695870e-11 7.545437e-16   FALSE
ENST00000559769 ENSG00000104093 HEK293_OSMI2_2hA HEK293_TMG_2hB DMXL2 protein_coding retained_intron 5.463978 2.824399 6.606313 0.3618859 0.3239563 1.222985 1.0425269 1.46084575 0.4220223 0.23390714 0.09961009 -1.767468 0.27910417 0.514133333 0.0638000 -0.45033333 3.406676e-14 7.545437e-16   FALSE
ENST00000560211 ENSG00000104093 HEK293_OSMI2_2hA HEK293_TMG_2hB DMXL2 protein_coding retained_intron 5.463978 2.824399 6.606313 0.3618859 0.3239563 1.222985 0.3197189 0.03353319 0.3605952 0.03353319 0.07220997 3.089656 0.05550833 0.010600000 0.0541000 0.04350000 7.839763e-02 7.545437e-16   FALSE
ENST00000560891 ENSG00000104093 HEK293_OSMI2_2hA HEK293_TMG_2hB DMXL2 protein_coding protein_coding 5.463978 2.824399 6.606313 0.3618859 0.3239563 1.222985 1.3448086 0.21344485 2.0424878 0.06502400 0.29401770 3.199383 0.21028333 0.085200000 0.3097667 0.22456667 1.351165e-02 7.545437e-16 FALSE TRUE
ENST00000561079 ENSG00000104093 HEK293_OSMI2_2hA HEK293_TMG_2hB DMXL2 protein_coding retained_intron 5.463978 2.824399 6.606313 0.3618859 0.3239563 1.222985 0.3235919 0.03006678 0.6696293 0.03006678 0.07262762 4.084270 0.05027917 0.009533333 0.1022333 0.09270000 7.839301e-04 7.545437e-16 FALSE TRUE
MSTRG.10811.3 ENSG00000104093 HEK293_OSMI2_2hA HEK293_TMG_2hB DMXL2 protein_coding   5.463978 2.824399 6.606313 0.3618859 0.3239563 1.222985 0.8407912 0.00000000 1.7632345 0.00000000 0.13716654 7.470240 0.12695417 0.000000000 0.2671333 0.26713333 7.545437e-16 7.545437e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104093 E001 0.1817044 0.0387341753 5.836438e-02   15 51447711 51447787 77 - 0.000 0.265 12.205
ENSG00000104093 E002 0.1817044 0.0387341753 5.836438e-02   15 51447788 51447790 3 - 0.000 0.265 15.224
ENSG00000104093 E003 96.8520527 0.0353080753 7.221768e-10 1.100501e-08 15 51447791 51448811 1021 - 1.694 2.278 1.960
ENSG00000104093 E004 44.2040715 0.0016684625 6.618365e-08 6.961851e-07 15 51448812 51449193 382 - 1.439 1.806 1.249
ENSG00000104093 E005 20.3154264 0.0018818941 2.946181e-04 1.357985e-03 15 51450129 51450194 66 - 1.117 1.471 1.239
ENSG00000104093 E006 35.0477600 0.0006442125 1.462150e-06 1.172437e-05 15 51450195 51450346 152 - 1.336 1.697 1.238
ENSG00000104093 E007 1.4759374 0.0110273979 5.039374e-01 6.398670e-01 15 51450347 51450673 327 - 0.275 0.429 0.932
ENSG00000104093 E008 16.0233005 0.0011448317 2.162381e-02 5.489404e-02 15 51451645 51451697 53 - 1.045 1.308 0.938
ENSG00000104093 E009 0.7405235 0.0167153390 1.537786e-01 2.668068e-01 15 51453248 51453549 302 - 0.139 0.428 2.149
ENSG00000104093 E010 18.6916633 0.0009625866 2.826888e-03 9.754909e-03 15 51453550 51453641 92 - 1.096 1.404 1.087
ENSG00000104093 E011 11.5607137 0.0015079923 7.382398e-02 1.496328e-01 15 51455151 51455228 78 - 0.920 1.160 0.879
ENSG00000104093 E012 14.7079099 0.0049165932 5.366044e-02 1.156586e-01 15 51456066 51456193 128 - 1.009 1.252 0.872
ENSG00000104093 E013 7.6188699 0.0024540039 3.906576e-01 5.346233e-01 15 51456309 51456312 4 - 0.781 0.933 0.585
ENSG00000104093 E014 8.7647211 0.0027450955 2.432380e-01 3.779771e-01 15 51456313 51456324 12 - 0.824 1.011 0.705
ENSG00000104093 E015 13.5822594 0.0013371425 8.581818e-02 1.686991e-01 15 51456325 51456369 45 - 0.987 1.208 0.798
ENSG00000104093 E016 14.1951918 0.0012487837 3.524376e-01 4.966938e-01 15 51457328 51457371 44 - 1.025 1.160 0.489
ENSG00000104093 E017 20.0732269 0.0009778711 6.587705e-01 7.677861e-01 15 51457372 51457446 75 - 1.176 1.250 0.264
ENSG00000104093 E018 15.9753846 0.0026733642 5.146729e-01 6.494025e-01 15 51457447 51457466 20 - 1.083 1.184 0.363
ENSG00000104093 E019 23.4429153 0.0010102379 5.332157e-01 6.654422e-01 15 51458506 51458627 122 - 1.237 1.326 0.310
ENSG00000104093 E020 0.1515154 0.0419237617 9.095850e-01   15 51458628 51458708 81 - 0.052 0.000 -12.065
ENSG00000104093 E021 14.7922723 0.0014838582 6.578501e-01 7.671429e-01 15 51458709 51458795 87 - 1.069 1.045 -0.088
ENSG00000104093 E022 2.7367869 0.0072094445 7.252363e-01 8.185660e-01 15 51458796 51459190 395 - 0.480 0.428 -0.263
ENSG00000104093 E023 11.6216925 0.0014696445 5.629247e-01 6.904695e-01 15 51459598 51459660 63 - 0.981 0.932 -0.181
ENSG00000104093 E024 2.5862149 0.0057923989 6.711269e-01 7.774380e-01 15 51459661 51459782 122 - 0.442 0.547 0.514
ENSG00000104093 E025 2.7345822 0.0336478854 6.734391e-01 7.791397e-01 15 51463076 51463378 303 - 0.442 0.549 0.524
ENSG00000104093 E026 14.8180081 0.0015106156 6.272201e-01 7.430490e-01 15 51463379 51463496 118 - 1.073 1.045 -0.105
ENSG00000104093 E027 23.2332790 0.0018775864 9.459881e-01 9.700910e-01 15 51464675 51464876 202 - 1.247 1.270 0.083
ENSG00000104093 E028 17.9614829 0.0014022330 3.497264e-01 4.939177e-01 15 51465566 51465651 86 - 1.153 1.076 -0.277
ENSG00000104093 E029 18.8598511 0.0016227063 4.083674e-01 5.519611e-01 15 51466184 51466311 128 - 1.169 1.106 -0.224
ENSG00000104093 E030 20.6522788 0.0010036312 7.394756e-01 8.291611e-01 15 51471223 51471401 179 - 1.187 1.251 0.226
ENSG00000104093 E031 23.3824250 0.0010760430 9.707912e-01 9.857560e-01 15 51474344 51474592 249 - 1.243 1.271 0.096
ENSG00000104093 E032 21.7316290 0.0258101870 7.668142e-01 8.492082e-01 15 51476589 51476716 128 - 1.209 1.273 0.227
ENSG00000104093 E033 5.5258107 0.0032405845 6.442177e-01 7.565707e-01 15 51476717 51476719 3 - 0.680 0.781 0.414
ENSG00000104093 E034 17.2726141 0.0010879926 7.340103e-01 8.250920e-01 15 51478271 51478347 77 - 1.117 1.184 0.239
ENSG00000104093 E035 23.6137057 0.0014527316 1.716551e-01 2.903738e-01 15 51479948 51480139 192 - 1.271 1.160 -0.393
ENSG00000104093 E036 75.5742790 0.0003479762 1.314260e-06 1.063892e-05 15 51480542 51481623 1082 - 1.775 1.495 -0.954
ENSG00000104093 E037 19.0275788 0.0009548037 2.176993e-03 7.770605e-03 15 51486073 51486337 265 - 1.208 0.838 -1.363
ENSG00000104093 E038 14.3199987 0.0154522595 3.161206e-02 7.509762e-02 15 51487954 51488119 166 - 1.088 0.781 -1.155
ENSG00000104093 E039 10.7348133 0.0021374940 2.507898e-02 6.203580e-02 15 51488548 51488645 98 - 0.975 0.640 -1.329
ENSG00000104093 E040 16.6283773 0.0011272461 1.173136e-02 3.289284e-02 15 51491578 51491747 170 - 1.146 0.838 -1.142
ENSG00000104093 E041 14.9599751 0.0020803439 9.938642e-04 3.937361e-03 15 51495024 51495134 111 - 1.117 0.640 -1.848
ENSG00000104093 E042 84.1114774 0.0430541783 1.535915e-05 9.779338e-05 15 51498552 51500231 1680 - 1.837 1.361 -1.626
ENSG00000104093 E043 17.4153899 0.0127824441 3.167599e-04 1.447653e-03 15 51502806 51503033 228 - 1.183 0.640 -2.082
ENSG00000104093 E044 7.6919903 0.0021282589 1.480625e-04 7.387022e-04 15 51507134 51507253 120 - 0.878 0.000 -16.825
ENSG00000104093 E045 9.7926534 0.0017895347 3.126186e-04 1.431100e-03 15 51514442 51514559 118 - 0.963 0.265 -3.286
ENSG00000104093 E046 8.4649946 0.0019924310 1.133236e-03 4.415272e-03 15 51517078 51517167 90 - 0.906 0.265 -3.071
ENSG00000104093 E047 12.4615868 0.0014799610 2.373260e-04 1.122194e-03 15 51535663 51535784 122 - 1.054 0.428 -2.621
ENSG00000104093 E048 36.9767256 0.0006185209 1.582887e-09 2.262169e-08 15 51536166 51536862 697 - 1.497 0.838 -2.369
ENSG00000104093 E049 18.5966709 0.0009926762 4.541331e-05 2.585006e-04 15 51537488 51537759 272 - 1.211 0.639 -2.183
ENSG00000104093 E050 18.4235453 0.0106162430 1.354889e-04 6.833672e-04 15 51538213 51538452 240 - 1.207 0.639 -2.170
ENSG00000104093 E051 14.9952326 0.0014832489 3.242847e-02 7.668417e-02 15 51542333 51542507 175 - 1.100 0.838 -0.979
ENSG00000104093 E052 15.9894441 0.0105165822 9.797873e-03 2.826437e-02 15 51545583 51545766 184 - 1.134 0.782 -1.318
ENSG00000104093 E053 10.1723841 0.0241600249 3.256232e-05 1.920465e-04 15 51547230 51547331 102 - 0.986 0.000 -17.095
ENSG00000104093 E054 6.1959780 0.0108748766 8.772225e-04 3.534393e-03 15 51547332 51547408 77 - 0.799 0.000 -16.611
ENSG00000104093 E055 5.5956162 0.0034723169 5.752934e-01 7.009278e-01 15 51563381 51563447 67 - 0.713 0.639 -0.308
ENSG00000104093 E056 8.8367076 0.0019669295 1.989006e-01 3.248289e-01 15 51564125 51564260 136 - 0.892 0.716 -0.697
ENSG00000104093 E057 8.5100565 0.0019707286 2.546947e-01 3.914551e-01 15 51565088 51565166 79 - 0.871 0.716 -0.614
ENSG00000104093 E058 0.0000000       15 51567043 51568486 1444 -      
ENSG00000104093 E059 8.2061058 0.0059175988 8.837184e-01 9.296237e-01 15 51568487 51568558 72 - 0.832 0.838 0.022
ENSG00000104093 E060 9.3141787 0.0020422055 8.119870e-01 8.807161e-01 15 51576056 51576181 126 - 0.871 0.933 0.235
ENSG00000104093 E061 0.0000000       15 51603607 51603701 95 -      
ENSG00000104093 E062 13.5248944 0.0523226585 3.847400e-01 5.288817e-01 15 51622459 51622833 375 - 1.046 0.934 -0.412