ENSG00000104067

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346128 ENSG00000104067 HEK293_OSMI2_2hA HEK293_TMG_2hB TJP1 protein_coding protein_coding 11.65845 6.971863 16.62525 0.7707825 0.5785376 1.25256 0.3098859 0.6968575 0.167727 0.09260758 0.05655679 -1.9917562 0.03925417 0.1003333 0.009966667 -0.09036667 5.177557e-09 2.31553e-17 FALSE TRUE
ENST00000400007 ENSG00000104067 HEK293_OSMI2_2hA HEK293_TMG_2hB TJP1 protein_coding protein_coding 11.65845 6.971863 16.62525 0.7707825 0.5785376 1.25256 2.6696774 2.2209069 3.246869 0.44367006 0.39870262 0.5458552 0.24925833 0.3116667 0.194166667 -0.11750000 7.047840e-02 2.31553e-17 FALSE FALSE
ENST00000400011 ENSG00000104067 HEK293_OSMI2_2hA HEK293_TMG_2hB TJP1 protein_coding protein_coding 11.65845 6.971863 16.62525 0.7707825 0.5785376 1.25256 5.2728419 3.8393227 6.769711 0.21040034 0.42324314 0.8166191 0.47851667 0.5583000 0.406433333 -0.15186667 1.590600e-02 2.31553e-17 FALSE TRUE
ENST00000614355 ENSG00000104067 HEK293_OSMI2_2hA HEK293_TMG_2hB TJP1 protein_coding protein_coding 11.65845 6.971863 16.62525 0.7707825 0.5785376 1.25256 0.6498237 0.0000000 1.088919 0.00000000 0.23953957 6.7799410 0.05021250 0.0000000 0.066600000 0.06660000 1.731668e-06 2.31553e-17 FALSE TRUE
ENST00000677774 ENSG00000104067 HEK293_OSMI2_2hA HEK293_TMG_2hB TJP1 protein_coding protein_coding 11.65845 6.971863 16.62525 0.7707825 0.5785376 1.25256 1.3785811 0.0000000 3.152568 0.00000000 0.26390095 8.3049525 0.08517500 0.0000000 0.191233333 0.19123333 2.315530e-17 2.31553e-17 FALSE TRUE
MSTRG.10351.8 ENSG00000104067 HEK293_OSMI2_2hA HEK293_TMG_2hB TJP1 protein_coding   11.65845 6.971863 16.62525 0.7707825 0.5785376 1.25256 0.8134488 0.0000000 1.485029 0.00000000 0.12456402 7.2240294 0.05565417 0.0000000 0.090000000 0.09000000 1.447771e-11 2.31553e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104067 E001 5.2314758 0.0031989989 4.881049e-08 5.274656e-07 15 29699367 29700151 785 - 0.375 1.145 3.237
ENSG00000104067 E002 33.5489441 0.0046434164 1.962075e-20 1.321868e-18 15 29700152 29700234 83 - 1.168 1.855 2.362
ENSG00000104067 E003 210.6848358 0.0145682668 2.565022e-19 1.517601e-17 15 29700235 29700772 538 - 2.006 2.611 2.019
ENSG00000104067 E004 226.9598111 0.0088926884 2.798698e-08 3.169565e-07 15 29700773 29701244 472 - 2.194 2.522 1.096
ENSG00000104067 E005 89.9711488 0.0006326583 3.265409e-06 2.424162e-05 15 29701245 29701388 144 - 1.829 2.069 0.806
ENSG00000104067 E006 107.2508326 0.0003135023 5.692669e-04 2.418775e-03 15 29701389 29701594 206 - 1.931 2.111 0.602
ENSG00000104067 E007 80.5037437 0.0003472920 5.118031e-02 1.112577e-01 15 29701595 29701689 95 - 1.828 1.965 0.461
ENSG00000104067 E008 25.6129266 0.0156384643 8.804019e-01 9.272986e-01 15 29704162 29704200 39 - 1.376 1.422 0.159
ENSG00000104067 E009 39.3886336 0.0141231170 5.489938e-01 6.787780e-01 15 29704201 29704221 21 - 1.531 1.639 0.366
ENSG00000104067 E010 67.1265425 0.0004354003 3.030665e-03 1.035625e-02 15 29704222 29704305 84 - 1.727 1.917 0.639
ENSG00000104067 E011 107.7568146 0.0009782294 1.172572e-05 7.668473e-05 15 29705528 29705745 218 - 1.919 2.139 0.738
ENSG00000104067 E012 185.0146902 0.0002012888 2.247772e-02 5.667957e-02 15 29708559 29709036 478 - 2.193 2.312 0.397
ENSG00000104067 E013 71.1780890 0.0003897405 9.886943e-01 9.969716e-01 15 29710831 29711000 170 - 1.802 1.859 0.193
ENSG00000104067 E014 97.3368798 0.0003634015 5.300192e-01 6.627293e-01 15 29716611 29716838 228 - 1.930 2.011 0.271
ENSG00000104067 E015 74.4298902 0.0010349431 7.884616e-01 8.645826e-01 15 29718021 29718118 98 - 1.822 1.890 0.230
ENSG00000104067 E016 190.0672624 0.0002237241 2.401466e-04 1.133890e-03 15 29718266 29718892 627 - 2.257 2.211 -0.156
ENSG00000104067 E017 105.4128017 0.0002956707 1.285640e-06 1.043042e-05 15 29718893 29719138 246 - 2.026 1.893 -0.445
ENSG00000104067 E018 5.9129388 0.0029856495 4.426276e-01 5.842173e-01 15 29719777 29720016 240 - 0.825 0.768 -0.228
ENSG00000104067 E019 0.1515154 0.0431016128 1.000000e+00   15 29720017 29720128 112 - 0.078 0.000 -9.826
ENSG00000104067 E020 117.4634986 0.0002872000 5.708784e-08 6.074886e-07 15 29720358 29720708 351 - 2.076 1.931 -0.487
ENSG00000104067 E021 47.0562912 0.0034615610 1.159942e-02 3.258270e-02 15 29726379 29726479 101 - 1.675 1.571 -0.353
ENSG00000104067 E022 67.7721852 0.0055143640 5.594059e-03 1.753873e-02 15 29726781 29726991 211 - 1.834 1.727 -0.363
ENSG00000104067 E023 40.6904640 0.0264032053 6.693558e-02 1.382806e-01 15 29727937 29728019 83 - 1.623 1.502 -0.413
ENSG00000104067 E024 0.4482035 0.0275111653 3.292696e-01 4.727759e-01 15 29732134 29732432 299 - 0.201 0.000 -11.411
ENSG00000104067 E025 45.2943167 0.0006634009 6.855965e-03 2.085187e-02 15 29732433 29732528 96 - 1.660 1.557 -0.350
ENSG00000104067 E026 65.4920054 0.0003839582 8.345479e-09 1.043444e-07 15 29732631 29732815 185 - 1.847 1.607 -0.813
ENSG00000104067 E027 0.1472490 0.0437155037 1.000000e+00   15 29732816 29732933 118 - 0.078 0.000 -9.825
ENSG00000104067 E028 73.7463757 0.0017163427 2.821064e-07 2.625090e-06 15 29733094 29733313 220 - 1.889 1.682 -0.701
ENSG00000104067 E029 45.8845877 0.0005606808 2.106368e-06 1.630486e-05 15 29734274 29734382 109 - 1.691 1.456 -0.803
ENSG00000104067 E030 60.9652028 0.0117227412 7.531908e-03 2.259501e-02 15 29737264 29737414 151 - 1.790 1.656 -0.453
ENSG00000104067 E031 0.1817044 0.0391162631 1.996496e-01   15 29741022 29741330 309 - 0.000 0.188 12.473
ENSG00000104067 E032 50.3183591 0.0064942748 2.165485e-04 1.034926e-03 15 29741331 29741436 106 - 1.724 1.525 -0.678
ENSG00000104067 E033 51.8703716 0.0004671568 4.941464e-08 5.332947e-07 15 29742642 29742781 140 - 1.749 1.487 -0.892
ENSG00000104067 E034 0.0000000       15 29742782 29743029 248 -      
ENSG00000104067 E035 1.2190178 0.0106554531 2.635262e-01 4.014495e-01 15 29758903 29760308 1406 - 0.375 0.188 -1.347
ENSG00000104067 E036 54.1662490 0.0008040563 2.821138e-08 3.193070e-07 15 29761139 29761286 148 - 1.768 1.502 -0.905
ENSG00000104067 E037 58.3505572 0.0005392132 2.047611e-06 1.589380e-05 15 29761601 29761769 169 - 1.788 1.589 -0.677
ENSG00000104067 E038 42.6012824 0.0005359317 1.201895e-05 7.839634e-05 15 29762335 29762438 104 - 1.658 1.439 -0.751
ENSG00000104067 E039 88.5939978 0.0003179341 5.493114e-16 2.148780e-14 15 29766266 29766542 277 - 1.990 1.676 -1.058
ENSG00000104067 E040 56.9045142 0.0004688614 9.274495e-17 4.012389e-15 15 29772064 29772166 103 - 1.820 1.374 -1.522
ENSG00000104067 E041 51.1320467 0.0015008509 1.100040e-12 2.678310e-11 15 29773233 29773357 125 - 1.768 1.365 -1.381
ENSG00000104067 E042 0.0000000       15 29800496 29800645 150 -      
ENSG00000104067 E043 29.5837005 0.0006946224 2.759415e-09 3.773644e-08 15 29800646 29800702 57 - 1.541 1.110 -1.506
ENSG00000104067 E044 1.3621141 0.1723059197 2.879994e-01 4.285416e-01 15 29820527 29820674 148 - 0.410 0.188 -1.535
ENSG00000104067 E045 0.1817044 0.0391162631 1.996496e-01   15 29821416 29821548 133 - 0.000 0.188 12.473
ENSG00000104067 E046 32.6326463 0.0008332141 3.514477e-06 2.591294e-05 15 29822002 29822503 502 - 1.560 1.275 -0.987
ENSG00000104067 E047 6.1207682 0.0026599815 3.881388e-01 5.322536e-01 15 29956232 29956364 133 - 0.838 0.768 -0.276
ENSG00000104067 E048 3.9344700 0.0154138763 5.792584e-01 7.041968e-01 15 29968667 29968921 255 - 0.674 0.628 -0.199