ENSG00000104044

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353809 ENSG00000104044 HEK293_OSMI2_2hA HEK293_TMG_2hB OCA2 protein_coding protein_coding 2.452405 2.660355 2.181899 0.1254288 0.09618409 -0.2848503 1.109040 1.466661 0.3506755 0.2042349 0.07521386 -2.0335657 0.4471208 0.5560667 0.1596000 -0.3964667 0.001015623 0.001015623 FALSE TRUE
ENST00000354638 ENSG00000104044 HEK293_OSMI2_2hA HEK293_TMG_2hB OCA2 protein_coding protein_coding 2.452405 2.660355 2.181899 0.1254288 0.09618409 -0.2848503 1.266301 1.170815 1.7550527 0.2465269 0.05283382 0.5799288 0.5240833 0.4357333 0.8069333 0.3712000 0.002400114 0.001015623 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000104044 E001 52.5877016 0.0209020361 0.117837341 0.21683674 15 27754875 27755472 598 - 1.630 1.758 0.435
ENSG00000104044 E002 18.6744002 0.0009965561 0.004983670 0.01588501 15 27844959 27845052 94 - 1.121 1.355 0.823
ENSG00000104044 E003 19.0294640 0.0010085655 0.003955130 0.01301693 15 27851382 27851475 94 - 1.121 1.360 0.842
ENSG00000104044 E004 16.7403715 0.0014060785 0.058059252 0.12330825 15 27871154 27871258 105 - 1.121 1.286 0.583
ENSG00000104044 E005 11.0253326 0.0021139156 0.464520409 0.60424333 15 27871863 27871922 60 - 1.007 1.083 0.277
ENSG00000104044 E006 18.7194759 0.0153607129 0.420263701 0.56346964 15 27926127 27926254 128 - 1.320 1.243 -0.268
ENSG00000104044 E007 15.6921562 0.0019513165 0.289814381 0.43055234 15 27951784 27951892 109 - 1.146 1.240 0.333
ENSG00000104044 E008 12.4516960 0.0015167634 0.009898566 0.02851442 15 27955158 27955215 58 - 0.936 1.196 0.944
ENSG00000104044 E009 22.8009788 0.0008274472 0.037451507 0.08631269 15 27957588 27957735 148 - 1.260 1.414 0.538
ENSG00000104044 E010 27.3158522 0.0041614137 0.919975764 0.95345152 15 27966690 27966822 133 - 1.443 1.437 -0.021
ENSG00000104044 E011 29.0344294 0.0007873857 0.274953792 0.41418848 15 27983345 27983483 139 - 1.504 1.437 -0.232
ENSG00000104044 E012 21.4464935 0.0064317079 0.131749245 0.23655602 15 27985064 27985188 125 - 1.405 1.287 -0.414
ENSG00000104044 E013 13.1191755 0.0014384030 0.750077314 0.83685151 15 27986587 27986643 57 - 1.157 1.130 -0.100
ENSG00000104044 E014 12.9435628 0.0387854974 0.412960730 0.55651393 15 27989601 27989666 66 - 1.201 1.089 -0.401
ENSG00000104044 E015 7.8628835 0.0049939723 0.005692108 0.01779578 15 27990576 27990647 72 - 1.095 0.778 -1.196
ENSG00000104044 E016 17.2258325 0.0195729406 0.165616179 0.28251189 15 28014776 28014929 154 - 1.327 1.183 -0.505
ENSG00000104044 E017 15.0365789 0.0049553045 0.524704978 0.65816510 15 28016104 28016186 83 - 1.222 1.165 -0.201
ENSG00000104044 E018 8.4169277 0.0024465208 0.907645577 0.94538106 15 28018397 28018411 15 - 0.955 0.969 0.053
ENSG00000104044 E019 15.9442770 0.0084123682 0.395432148 0.53924041 15 28018412 28018557 146 - 1.269 1.194 -0.263
ENSG00000104044 E020 13.0162419 0.0046246343 0.031662608 0.07519319 15 28022501 28022573 73 - 1.250 1.051 -0.713
ENSG00000104044 E021 15.9566481 0.0132216870 0.161830925 0.27751924 15 28024845 28024902 58 - 1.295 1.163 -0.465
ENSG00000104044 E022 22.9657084 0.0012374618 0.217652211 0.34757535 15 28027871 28028059 189 - 1.418 1.333 -0.297
ENSG00000104044 E023 16.3920031 0.0013857033 0.128570066 0.23216804 15 28032065 28032163 99 - 1.303 1.180 -0.434
ENSG00000104044 E024 19.5876758 0.0137900882 0.847552042 0.90533017 15 28081648 28081895 248 - 1.303 1.289 -0.050
ENSG00000104044 E025 0.5202097 0.0203000565 0.396987124 0.54075755 15 28099111 28099223 113 - 0.247 0.107 -1.456
ENSG00000104044 E026 8.3160504 0.0286230714 0.955947659 0.97638270 15 28099224 28099315 92 - 0.936 0.948 0.045