ENSG00000103995

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325747 ENSG00000103995 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP152 protein_coding protein_coding 3.17394 0.7310592 4.293631 0.1047766 0.1452065 2.537894 0.8553491 0.1408115 1.1887269 0.03344107 0.08969795 2.990685 0.25453750 0.1950667 0.2760667 0.0810000 0.61083378 0.03597866 FALSE TRUE
ENST00000380950 ENSG00000103995 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP152 protein_coding protein_coding 3.17394 0.7310592 4.293631 0.1047766 0.1452065 2.537894 1.5953226 0.5870379 2.1589536 0.09408247 0.35928306 1.861105 0.58587083 0.7991667 0.4986000 -0.3005667 0.03597866 0.03597866 FALSE TRUE
ENST00000399334 ENSG00000103995 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP152 protein_coding protein_coding 3.17394 0.7310592 4.293631 0.1047766 0.1452065 2.537894 0.4384410 0.0000000 0.6134704 0.00000000 0.30795760 5.962249 0.08722083 0.0000000 0.1474333 0.1474333 0.47697107 0.03597866 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103995 E001 0.3666179 0.0272049630 1.939000e-01 3.186842e-01 15 48664854 48664907 54 - 0.054 0.255 2.590
ENSG00000103995 E002 0.1451727 0.0430590381 9.707419e-01   15 48712928 48713210 283 - 0.054 0.001 -6.631
ENSG00000103995 E003 1.5887561 0.0091320969 2.046783e-01 3.319851e-01 15 48717018 48717169 152 - 0.285 0.531 1.365
ENSG00000103995 E004 8.9169572 0.0032979241 1.798115e-07 1.739151e-06 15 48737938 48738150 213 - 0.709 1.304 2.218
ENSG00000103995 E005 61.3250257 0.0005656723 3.777133e-26 4.549056e-24 15 48738151 48738940 790 - 1.532 2.030 1.683
ENSG00000103995 E006 30.2230999 0.0006964300 1.080895e-05 7.125739e-05 15 48738941 48739288 348 - 1.295 1.612 1.092
ENSG00000103995 E007 30.3770214 0.0017738971 3.049040e-01 4.469379e-01 15 48740506 48741600 1095 - 1.355 1.437 0.283
ENSG00000103995 E008 5.5221992 0.0162236738 5.549904e-01 6.838946e-01 15 48741601 48741630 30 - 0.731 0.622 -0.459
ENSG00000103995 E009 9.2382176 0.0776146619 7.086200e-01 8.062417e-01 15 48741631 48741704 74 - 0.889 0.950 0.230
ENSG00000103995 E010 12.2763614 0.0014274024 2.643101e-01 4.022748e-01 15 48741947 48742100 154 - 0.984 1.113 0.471
ENSG00000103995 E011 14.8652233 0.0021322455 7.867314e-01 8.634070e-01 15 48744240 48744343 104 - 1.089 1.056 -0.123
ENSG00000103995 E012 15.5912903 0.0012299122 8.860803e-02 1.729981e-01 15 48744896 48744992 97 - 1.130 0.913 -0.798
ENSG00000103995 E013 15.9877756 0.0184807313 2.756866e-02 6.714837e-02 15 48748443 48748610 168 - 1.151 0.819 -1.236
ENSG00000103995 E014 14.9110404 0.0012292777 9.527538e-01 9.744003e-01 15 48752349 48752469 121 - 1.080 1.085 0.020
ENSG00000103995 E015 46.8913223 0.0008075172 9.040956e-02 1.757691e-01 15 48755903 48756553 651 - 1.573 1.449 -0.423
ENSG00000103995 E016 17.2990290 0.0090950770 1.542698e-01 2.674726e-01 15 48760135 48760266 132 - 1.170 0.990 -0.654
ENSG00000103995 E017 31.0129721 0.0008113359 8.574022e-01 9.119364e-01 15 48762391 48762672 282 - 1.384 1.368 -0.057
ENSG00000103995 E018 17.7711556 0.0012323684 6.863428e-01 7.888845e-01 15 48767060 48767192 133 - 1.159 1.113 -0.164
ENSG00000103995 E019 16.8885563 0.0011108450 1.706842e-01 2.890488e-01 15 48767335 48767463 129 - 1.155 0.990 -0.597
ENSG00000103995 E020 17.5897623 0.0010954400 7.121778e-01 8.089938e-01 15 48768219 48768328 110 - 1.155 1.113 -0.150
ENSG00000103995 E021 11.0409726 0.0065173465 7.655512e-01 8.482805e-01 15 48768956 48768972 17 - 0.953 0.991 0.142
ENSG00000103995 E022 16.2784265 0.0012031437 5.796982e-01 7.045374e-01 15 48768973 48769081 109 - 1.121 1.056 -0.235
ENSG00000103995 E023 8.9017672 0.0257883867 4.250804e-01 5.680222e-01 15 48772487 48772514 28 - 0.898 0.765 -0.519
ENSG00000103995 E024 12.9716878 0.0017976492 3.193484e-01 4.624220e-01 15 48772515 48772691 177 - 1.045 0.913 -0.491
ENSG00000103995 E025 0.0000000       15 48773255 48773531 277 -      
ENSG00000103995 E026 11.6688108 0.0015079599 2.915411e-02 7.029780e-02 15 48781196 48781359 164 - 1.029 0.698 -1.281
ENSG00000103995 E027 9.3870942 0.0032911380 1.378614e-01 2.450982e-01 15 48782139 48782230 92 - 0.933 0.698 -0.923
ENSG00000103995 E028 5.7969891 0.0043631135 4.995791e-01 6.358740e-01 15 48783973 48783982 10 - 0.741 0.622 -0.500
ENSG00000103995 E029 14.7345339 0.0012258148 6.218307e-01 7.387450e-01 15 48783983 48784120 138 - 1.085 1.024 -0.220
ENSG00000103995 E030 17.6536680 0.0010506289 1.209444e-01 2.212961e-01 15 48788801 48789001 201 - 1.174 0.990 -0.667
ENSG00000103995 E031 0.0000000       15 48789238 48789322 85 -      
ENSG00000103995 E032 13.7342333 0.0355776497 5.291311e-02 1.143274e-01 15 48791237 48791376 140 - 1.089 0.765 -1.222
ENSG00000103995 E033 10.5258136 0.0501708286 1.129235e-01 2.098074e-01 15 48793321 48793461 141 - 0.984 0.699 -1.109
ENSG00000103995 E034 11.5774057 0.0055465311 7.920228e-01 8.669791e-01 15 48796010 48796160 151 - 0.989 0.953 -0.134
ENSG00000103995 E035 18.2632552 0.0019207916 1.668617e-01 2.841092e-01 15 48797301 48797579 279 - 1.186 1.024 -0.583
ENSG00000103995 E036 6.6738294 0.0026901007 1.244134e-01 2.262688e-01 15 48797661 48797670 10 - 0.809 0.531 -1.185
ENSG00000103995 E037 9.8003039 0.0241416379 2.061459e-02 5.277674e-02 15 48797671 48797716 46 - 0.966 0.531 -1.781
ENSG00000103995 E038 7.3947611 0.0195205674 2.644414e-02 6.483704e-02 15 48797717 48797730 14 - 0.860 0.415 -1.967
ENSG00000103995 E039 0.0000000       15 48797731 48797947 217 -      
ENSG00000103995 E040 16.8081086 0.0010352657 6.721692e-04 2.796662e-03 15 48797948 48798051 104 - 1.182 0.698 -1.832
ENSG00000103995 E041 0.0000000       15 48805520 48805562 43 -      
ENSG00000103995 E042 17.1371652 0.0010148079 1.777313e-05 1.115033e-04 15 48805563 48805656 94 - 1.201 0.531 -2.635
ENSG00000103995 E043 0.0000000       15 48810219 48810594 376 -      
ENSG00000103995 E044 11.6281014 0.0014486438 3.988769e-04 1.770028e-03 15 48810961 48811146 186 - 1.045 0.414 -2.661