ENSG00000103876

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261755 ENSG00000103876 HEK293_OSMI2_2hA HEK293_TMG_2hB FAH protein_coding protein_coding 39.70294 70.4274 20.29847 3.101291 0.8593057 -1.79426 5.826812 11.936476 2.0430003 1.3672590 0.71904909 -2.5407794 0.13370833 0.1685333 0.10366667 -0.064866667 0.38889963 5.021079e-07 FALSE TRUE
ENST00000407106 ENSG00000103876 HEK293_OSMI2_2hA HEK293_TMG_2hB FAH protein_coding protein_coding 39.70294 70.4274 20.29847 3.101291 0.8593057 -1.79426 7.759056 15.306663 4.4951684 0.4186029 0.09634226 -1.7654491 0.19697083 0.2182000 0.22196667 0.003766667 0.96538327 5.021079e-07 FALSE TRUE
ENST00000558022 ENSG00000103876 HEK293_OSMI2_2hA HEK293_TMG_2hB FAH protein_coding protein_coding 39.70294 70.4274 20.29847 3.101291 0.8593057 -1.79426 9.468076 12.259173 6.3174124 2.4434988 0.54658420 -0.9553505 0.27104583 0.1720000 0.31003333 0.138033333 0.01184979 5.021079e-07 FALSE FALSE
ENST00000558767 ENSG00000103876 HEK293_OSMI2_2hA HEK293_TMG_2hB FAH protein_coding protein_coding 39.70294 70.4274 20.29847 3.101291 0.8593057 -1.79426 1.936980 3.710036 0.9314761 0.3266066 0.12040631 -1.9823202 0.05235833 0.0530000 0.04656667 -0.006433333 0.83722625 5.021079e-07 FALSE TRUE
ENST00000561421 ENSG00000103876 HEK293_OSMI2_2hA HEK293_TMG_2hB FAH protein_coding protein_coding 39.70294 70.4274 20.29847 3.101291 0.8593057 -1.79426 10.523361 22.346885 4.0076765 1.3905509 0.93507905 -2.4762859 0.23282917 0.3201000 0.19570000 -0.124400000 0.18696144 5.021079e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103876 E001 0.0000000       15 80152490 80152545 56 +      
ENSG00000103876 E002 0.4396707 0.0264974849 2.252385e-03 8.006520e-03 15 80152780 80152788 9 + 0.496 0.000 -13.589
ENSG00000103876 E003 1.2480608 0.0102286979 4.581351e-03 1.476763e-02 15 80152789 80152791 3 + 0.659 0.160 -2.998
ENSG00000103876 E004 2.1681978 0.0066394872 1.642051e-02 4.365690e-02 15 80152792 80152793 2 + 0.722 0.310 -2.038
ENSG00000103876 E005 22.1729602 0.0037782200 1.611187e-01 2.765758e-01 15 80152794 80152841 48 + 1.321 1.193 -0.449
ENSG00000103876 E006 0.2955422 0.0298770965 2.512655e-01   15 80152842 80152854 13 + 0.234 0.060 -2.263
ENSG00000103876 E007 53.7454888 0.0024897954 1.280882e-02 3.546406e-02 15 80152855 80152905 51 + 1.712 1.560 -0.518
ENSG00000103876 E008 8.3144208 0.0020913173 6.430280e-01 7.556587e-01 15 80152906 80152979 74 + 0.777 0.851 0.289
ENSG00000103876 E009 29.4739531 0.0047862188 7.554046e-01 8.407596e-01 15 80152980 80152998 19 + 1.306 1.340 0.119
ENSG00000103876 E010 30.1080151 0.0013503100 6.097737e-01 7.291858e-01 15 80152999 80153000 2 + 1.377 1.339 -0.130
ENSG00000103876 E011 34.3034993 0.0014515855 7.603778e-01 8.445190e-01 15 80153001 80153009 9 + 1.414 1.395 -0.066
ENSG00000103876 E012 65.5976361 0.0003688802 4.371882e-01 5.791969e-01 15 80153010 80153025 16 + 1.706 1.667 -0.132
ENSG00000103876 E013 166.1091130 0.0002119368 3.291092e-03 1.112377e-02 15 80153026 80153033 8 + 2.155 2.056 -0.329
ENSG00000103876 E014 214.3464169 0.0001909363 2.020805e-01 3.288004e-01 15 80153034 80153054 21 + 2.211 2.176 -0.118
ENSG00000103876 E015 339.2144104 0.0001665384 9.849669e-03 2.839563e-02 15 80153055 80153135 81 + 2.430 2.370 -0.199
ENSG00000103876 E016 0.4386386 0.1428236961 7.222427e-02 1.470370e-01 15 80155951 80156491 541 + 0.384 0.060 -3.270
ENSG00000103876 E017 4.9284475 0.0043084496 8.542330e-02 1.680881e-01 15 80156492 80158059 1568 + 0.870 0.615 -1.040
ENSG00000103876 E018 323.9357101 0.0003162213 3.140914e-03 1.067982e-02 15 80158060 80158101 42 + 2.420 2.348 -0.241
ENSG00000103876 E019 405.1025019 0.0001335996 4.442283e-03 1.437833e-02 15 80158102 80158170 69 + 2.507 2.448 -0.199
ENSG00000103876 E020 468.7299513 0.0002074342 6.859728e-04 2.848152e-03 15 80159756 80159877 122 + 2.579 2.512 -0.225
ENSG00000103876 E021 0.2965864 0.2072293074 1.000000e+00   15 80160058 80160299 242 + 0.000 0.111 10.814
ENSG00000103876 E022 297.4973982 0.0001697904 3.365385e-03 1.133746e-02 15 80160410 80160459 50 + 2.386 2.313 -0.243
ENSG00000103876 E023 1.5812780 0.0091320969 6.955868e-01 7.961619e-01 15 80160460 80160523 64 + 0.385 0.310 -0.453
ENSG00000103876 E024 1.8766313 0.2698314997 5.973944e-01 7.191624e-01 15 80160524 80162245 1722 + 0.233 0.405 1.115
ENSG00000103876 E025 369.3374435 0.0008182366 8.802059e-03 2.578892e-02 15 80162246 80162336 91 + 2.472 2.408 -0.215
ENSG00000103876 E026 9.3893115 0.0033104277 1.403904e-01 2.485704e-01 15 80162337 80162391 55 + 1.040 0.859 -0.678
ENSG00000103876 E027 92.7307470 0.0155746157 2.576689e-01 3.948316e-01 15 80162392 80163744 1353 + 1.892 1.815 -0.260
ENSG00000103876 E028 0.1472490 0.0424911269 8.321909e-02   15 80167103 80167242 140 + 0.234 0.000 -13.937
ENSG00000103876 E029 0.4031496 0.0249526254 1.000000e+00 1.000000e+00 15 80168051 80168051 1 + 0.000 0.113 11.704
ENSG00000103876 E030 346.7917609 0.0013579507 9.291157e-01 9.594258e-01 15 80168052 80168149 98 + 2.382 2.391 0.030
ENSG00000103876 E031 2.4013120 0.2252398551 8.321665e-03 2.459691e-02 15 80168150 80168263 114 + 0.871 0.277 -2.852
ENSG00000103876 E032 286.0559666 0.0002223312 6.139950e-01 7.325690e-01 15 80168264 80168316 53 + 2.313 2.304 -0.029
ENSG00000103876 E033 5.7728681 0.0069628025 5.235336e-04 2.247799e-03 15 80168317 80168419 103 + 1.068 0.599 -1.847
ENSG00000103876 E034 22.8123689 0.0026637584 7.959606e-19 4.452092e-17 15 80169717 80170801 1085 + 1.713 1.035 -2.363
ENSG00000103876 E035 209.3766297 0.0001910796 9.956333e-01 1.000000e+00 15 80172149 80172161 13 + 2.167 2.173 0.019
ENSG00000103876 E036 320.3922053 0.0001597855 8.166125e-01 8.839736e-01 15 80172162 80172206 45 + 2.345 2.357 0.040
ENSG00000103876 E037 334.1909041 0.0002913551 2.816215e-01 4.215411e-01 15 80172207 80172248 42 + 2.342 2.377 0.118
ENSG00000103876 E038 536.6047549 0.0001570498 1.328426e-02 3.657969e-02 15 80173014 80173144 131 + 2.527 2.586 0.196
ENSG00000103876 E039 2.3929790 0.0633733359 1.248809e-02 3.470641e-02 15 80173145 80173753 609 + 0.777 0.312 -2.245
ENSG00000103876 E040 401.0817994 0.0004369497 3.531563e-02 8.225783e-02 15 80175016 80175080 65 + 2.400 2.461 0.204
ENSG00000103876 E041 211.7519521 0.0010993180 9.569813e-02 1.839323e-01 15 80175081 80175091 11 + 2.116 2.185 0.230
ENSG00000103876 E042 0.5212538 0.0200477394 4.697704e-01 6.089984e-01 15 80175092 80175092 1 + 0.234 0.113 -1.261
ENSG00000103876 E043 0.8878717 0.0153312657 2.301382e-01 3.626291e-01 15 80177407 80177536 130 + 0.385 0.160 -1.674
ENSG00000103876 E044 302.8823459 0.0016114029 1.006153e-04 5.247132e-04 15 80177537 80177583 47 + 2.206 2.350 0.483
ENSG00000103876 E045 413.6897661 0.0012544217 5.038562e-11 9.359157e-10 15 80180124 80180225 102 + 2.281 2.494 0.707
ENSG00000103876 E046 3.6711971 0.2178013089 9.503015e-01 9.728975e-01 15 80180226 80180330 105 + 0.496 0.550 0.255
ENSG00000103876 E047 429.7669306 0.0016804749 5.872168e-06 4.115819e-05 15 80181042 80181159 118 + 2.354 2.504 0.500
ENSG00000103876 E048 317.9030746 0.0033645901 4.104431e-03 1.343646e-02 15 80186130 80186946 817 + 2.250 2.372 0.407