ENSG00000103855

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318443 ENSG00000103855 HEK293_OSMI2_2hA HEK293_TMG_2hB CD276 protein_coding protein_coding 71.39132 117.1896 51.75206 4.000559 1.587731 -1.179 19.735567 29.39274 14.689667 1.6771937 0.9344836 -1.0001671 0.2854875 0.2507333 0.28436667 3.363333e-02 5.753673e-01 6.744933e-09 FALSE TRUE
ENST00000559465 ENSG00000103855 HEK293_OSMI2_2hA HEK293_TMG_2hB CD276 protein_coding retained_intron 71.39132 117.1896 51.75206 4.000559 1.587731 -1.179 24.825562 54.00101 13.737683 3.6901951 1.3784605 -1.9740650 0.3184333 0.4617667 0.26466667 -1.971000e-01 1.057967e-03 6.744933e-09 FALSE FALSE
ENST00000560786 ENSG00000103855 HEK293_OSMI2_2hA HEK293_TMG_2hB CD276 protein_coding protein_coding 71.39132 117.1896 51.75206 4.000559 1.587731 -1.179 9.689215 11.63587 10.324920 0.4339171 0.5256504 -0.1722918 0.1440500 0.0995000 0.19970000 1.002000e-01 6.744933e-09 6.744933e-09 FALSE FALSE
ENST00000564751 ENSG00000103855 HEK293_OSMI2_2hA HEK293_TMG_2hB CD276 protein_coding protein_coding 71.39132 117.1896 51.75206 4.000559 1.587731 -1.179 7.048070 10.75571 4.786464 1.4249363 1.3709880 -1.1664003 0.1112542 0.0912000 0.09123333 3.333333e-05 9.663113e-01 6.744933e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103855 E001 0.5546650 0.0209636460 8.733025e-01 9.226037e-01 15 73683966 73684063 98 + 0.171 0.158 -0.137
ENSG00000103855 E002 1.2597021 0.2124782737 3.463524e-02 8.096072e-02 15 73684209 73684211 3 + 0.592 0.159 -2.722
ENSG00000103855 E003 2.6688433 0.3823783431 2.073167e-02 5.302131e-02 15 73684212 73684223 12 + 0.864 0.276 -2.833
ENSG00000103855 E004 5.8066253 0.1356569166 8.031511e-03 2.385915e-02 15 73684224 73684241 18 + 1.085 0.589 -1.953
ENSG00000103855 E005 6.3247586 0.1148442802 4.826693e-03 1.544834e-02 15 73684242 73684242 1 + 1.118 0.615 -1.960
ENSG00000103855 E006 11.0669028 0.1628434633 9.552377e-03 2.766486e-02 15 73684243 73684268 26 + 1.341 0.827 -1.873
ENSG00000103855 E007 14.8519654 0.1116793788 1.793272e-02 4.699089e-02 15 73684269 73684280 12 + 1.394 1.007 -1.378
ENSG00000103855 E008 30.6232920 0.0691267271 8.265492e-03 2.445568e-02 15 73684281 73684382 102 + 1.654 1.337 -1.087
ENSG00000103855 E009 20.8589656 0.0579655038 5.322190e-02 1.148874e-01 15 73684383 73684390 8 + 1.425 1.221 -0.714
ENSG00000103855 E010 38.9701822 0.0118257456 4.080545e-02 9.252176e-02 15 73684391 73684407 17 + 1.629 1.514 -0.392
ENSG00000103855 E011 59.5534828 0.0139125906 3.716039e-02 8.577952e-02 15 73684408 73684437 30 + 1.805 1.698 -0.361
ENSG00000103855 E012 64.0906971 0.0131721174 3.063130e-02 7.319821e-02 15 73684438 73684460 23 + 1.836 1.728 -0.365
ENSG00000103855 E013 4.2549473 0.0496975810 7.005864e-01 8.000241e-01 15 73684502 73684730 229 + 0.591 0.698 0.463
ENSG00000103855 E014 2.5994600 0.0150864679 7.403156e-01 8.297672e-01 15 73684731 73684771 41 + 0.533 0.505 -0.136
ENSG00000103855 E015 2.6736562 0.0238062412 8.277737e-01 8.917278e-01 15 73684772 73684799 28 + 0.467 0.535 0.328
ENSG00000103855 E016 1.4059164 0.0099936863 7.925176e-01 8.673307e-01 15 73684800 73684899 100 + 0.294 0.365 0.446
ENSG00000103855 E017 0.3299976 0.0277009629 5.680869e-01   15 73685006 73685083 78 + 0.000 0.158 9.401
ENSG00000103855 E018 1.1114078 0.0173468243 1.312078e-01 2.358375e-01 15 73690671 73690776 106 + 0.467 0.219 -1.556
ENSG00000103855 E019 0.1482932 0.0415101400 1.000000e+00   15 73697593 73697593 1 + 0.000 0.086 8.213
ENSG00000103855 E020 2.6464991 0.0059486629 1.492369e-01 2.606263e-01 15 73697594 73697595 2 + 0.294 0.586 1.561
ENSG00000103855 E021 6.4418575 0.0042908898 6.994797e-01 7.991954e-01 15 73697596 73697702 107 + 0.766 0.854 0.345
ENSG00000103855 E022 108.8479403 0.0043285568 3.458065e-02 8.086205e-02 15 73699586 73699639 54 + 2.029 1.970 -0.195
ENSG00000103855 E023 147.8990851 0.0022630081 1.706087e-01 2.889543e-01 15 73699640 73699718 79 + 2.127 2.116 -0.035
ENSG00000103855 E024 219.2351386 0.0017246500 5.777542e-02 1.228135e-01 15 73702255 73702379 125 + 2.302 2.284 -0.062
ENSG00000103855 E025 252.8067884 0.0002892157 2.413608e-03 8.502879e-03 15 73702380 73702593 214 + 2.376 2.342 -0.115
ENSG00000103855 E026 333.6702711 0.0003628465 1.195077e-06 9.762573e-06 15 73702772 73703086 315 + 2.519 2.453 -0.219
ENSG00000103855 E027 460.2684601 0.0003742363 2.476783e-08 2.835160e-07 15 73703659 73703908 250 + 2.657 2.591 -0.219
ENSG00000103855 E028 151.7762162 0.0022314084 3.565110e-02 8.290670e-02 15 73703909 73703950 42 + 2.155 2.118 -0.125
ENSG00000103855 E029 130.2678566 0.0008656958 1.098586e-01 2.053504e-01 15 73703951 73703997 47 + 2.075 2.059 -0.055
ENSG00000103855 E030 84.4963325 0.0003657638 9.358603e-01 9.636486e-01 15 73704176 73704196 21 + 1.849 1.886 0.126
ENSG00000103855 E031 350.0879877 0.0001439426 1.227810e-02 3.420058e-02 15 73704197 73704472 276 + 2.500 2.489 -0.036
ENSG00000103855 E032 168.2246077 0.0003367857 4.048403e-02 9.190848e-02 15 73708339 73708362 24 + 2.189 2.168 -0.071
ENSG00000103855 E033 364.0477212 0.0002182621 1.311110e-04 6.636718e-04 15 73708363 73708473 111 + 2.535 2.497 -0.126
ENSG00000103855 E034 4.1140331 0.0435003198 3.725673e-02 8.596315e-02 15 73708474 73708689 216 + 0.862 0.562 -1.248
ENSG00000103855 E035 3.1268571 0.0673060683 3.510195e-01 4.952234e-01 15 73709565 73709647 83 + 0.687 0.554 -0.581
ENSG00000103855 E036 326.3145430 0.0001691015 2.941290e-02 7.079658e-02 15 73709648 73709689 42 + 2.466 2.460 -0.020
ENSG00000103855 E037 5.0445757 0.0034658779 6.278549e-01 7.435332e-01 15 73711132 73711134 3 + 0.766 0.731 -0.140
ENSG00000103855 E038 292.3209629 0.0003773159 7.298357e-03 2.199678e-02 15 73711135 73711170 36 + 2.430 2.407 -0.075
ENSG00000103855 E039 17.5673787 0.0012093067 1.289788e-01 2.327464e-01 15 73711171 73712154 984 + 1.287 1.196 -0.322
ENSG00000103855 E040 453.2754358 0.0001789540 2.167620e-02 5.500183e-02 15 73712934 73713063 130 + 2.605 2.603 -0.004
ENSG00000103855 E041 666.4818839 0.0005894860 9.904068e-01 9.981307e-01 15 73713064 73713289 226 + 2.740 2.783 0.143
ENSG00000103855 E042 1226.3247843 0.0015419132 2.339689e-05 1.427941e-04 15 73713290 73713841 552 + 2.941 3.070 0.427
ENSG00000103855 E043 1424.8944801 0.0047969955 2.230647e-11 4.389627e-10 15 73713842 73714514 673 + 2.908 3.159 0.837