ENSG00000103852

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262074 ENSG00000103852 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC23 protein_coding protein_coding 8.467084 6.971808 7.422466 0.5494484 0.4625165 0.09024027 1.1451022 1.7968515 1.0176483 0.6581510 0.5814940 -0.81413131 0.14340417 0.25056667 0.12823333 -0.122333333 0.64855521 0.01061944 TRUE TRUE
ENST00000394132 ENSG00000103852 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC23 protein_coding protein_coding 8.467084 6.971808 7.422466 0.5494484 0.4625165 0.09024027 1.5652470 1.4710417 1.5319854 0.1097884 0.2173151 0.05817685 0.18472083 0.21120000 0.20883333 -0.002366667 0.99645312 0.01061944 FALSE TRUE
ENST00000459771 ENSG00000103852 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC23 protein_coding nonsense_mediated_decay 8.467084 6.971808 7.422466 0.5494484 0.4625165 0.09024027 0.8104585 0.3183641 0.8045652 0.2189372 0.4291133 1.31073386 0.09842083 0.05153333 0.11583333 0.064300000 0.65133425 0.01061944 TRUE TRUE
ENST00000494567 ENSG00000103852 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC23 protein_coding retained_intron 8.467084 6.971808 7.422466 0.5494484 0.4625165 0.09024027 0.8706742 1.3409566 0.1046545 0.2282810 0.1046545 -3.55861610 0.11272500 0.19443333 0.01586667 -0.178566667 0.02406505 0.01061944 FALSE TRUE
ENST00000560860 ENSG00000103852 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC23 protein_coding protein_coding 8.467084 6.971808 7.422466 0.5494484 0.4625165 0.09024027 0.7714446 0.1891890 0.5032263 0.1891890 0.2660670 1.36545721 0.08492083 0.02626667 0.06496667 0.038700000 0.63301648 0.01061944 FALSE FALSE
MSTRG.11637.10 ENSG00000103852 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC23 protein_coding   8.467084 6.971808 7.422466 0.5494484 0.4625165 0.09024027 0.2613167 0.0000000 0.3430152 0.0000000 0.3430152 5.14165847 0.02724167 0.00000000 0.05200000 0.052000000 0.85412152 0.01061944 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103852 E001 0.2214452 0.0430112828 5.354810e-01   15 99136323 99136323 1 - 0.000 0.116 8.912
ENSG00000103852 E002 10.7052756 0.0079518648 7.463977e-04 3.065511e-03 15 99136324 99136405 82 - 0.815 1.201 1.428
ENSG00000103852 E003 93.7600541 0.0034193850 2.980391e-09 4.044890e-08 15 99136406 99136774 369 - 1.801 2.074 0.915
ENSG00000103852 E004 150.5971398 0.0004221171 1.720235e-12 4.053905e-11 15 99136775 99137552 778 - 2.054 2.258 0.684
ENSG00000103852 E005 28.3357243 0.0008167485 2.649537e-01 4.029598e-01 15 99137553 99137575 23 - 1.425 1.499 0.256
ENSG00000103852 E006 27.0365881 0.0007480531 7.429165e-01 8.317278e-01 15 99137576 99137598 23 - 1.436 1.460 0.081
ENSG00000103852 E007 29.3244369 0.0008524858 3.681096e-01 5.125065e-01 15 99137599 99137639 41 - 1.452 1.512 0.204
ENSG00000103852 E008 47.3184430 0.0057722368 4.639324e-01 6.036940e-01 15 99137640 99137828 189 - 1.659 1.705 0.156
ENSG00000103852 E009 20.1155331 0.0010714585 4.253661e-01 5.683147e-01 15 99137829 99137847 19 - 1.358 1.300 -0.202
ENSG00000103852 E010 20.0621603 0.0009415686 6.686848e-01 7.756287e-01 15 99137848 99137852 5 - 1.338 1.307 -0.107
ENSG00000103852 E011 36.4003102 0.0006552935 7.746250e-01 8.547688e-01 15 99137853 99137941 89 - 1.580 1.566 -0.049
ENSG00000103852 E012 43.4559405 0.0006296070 4.999491e-01 6.362074e-01 15 99137942 99138127 186 - 1.625 1.662 0.127
ENSG00000103852 E013 4.1528828 0.1165912927 2.578357e-01 3.950168e-01 15 99139137 99139266 130 - 0.816 0.630 -0.765
ENSG00000103852 E014 24.6383646 0.0010514967 4.429854e-01 5.845471e-01 15 99139317 99139399 83 - 1.436 1.385 -0.178
ENSG00000103852 E015 2.4658283 0.0061075197 2.970716e-01 4.383877e-01 15 99139400 99139467 68 - 0.436 0.608 0.822
ENSG00000103852 E016 2.5347285 0.0061830591 8.114172e-01 8.803449e-01 15 99139468 99139576 109 - 0.534 0.574 0.184
ENSG00000103852 E017 0.1482932 0.0411597534 5.405461e-01   15 99139577 99139695 119 - 0.000 0.116 11.361
ENSG00000103852 E018 2.5358624 0.0059201735 2.156923e-01 3.452254e-01 15 99139696 99139744 49 - 0.649 0.453 -0.914
ENSG00000103852 E019 2.3917313 0.0064234852 1.674174e-01 2.848407e-01 15 99148512 99148709 198 - 0.377 0.609 1.145
ENSG00000103852 E020 1.2920680 0.0102239295 3.809237e-01 5.252135e-01 15 99151293 99151386 94 - 0.436 0.283 -0.914
ENSG00000103852 E021 8.9350846 0.0347923228 1.865568e-01 3.094259e-01 15 99155364 99156147 784 - 0.879 1.058 0.666
ENSG00000103852 E022 37.6129352 0.0111333982 7.261762e-01 8.192674e-01 15 99156148 99156297 150 - 1.600 1.569 -0.104
ENSG00000103852 E023 38.9016941 0.0005746555 6.391429e-01 7.525884e-01 15 99161740 99161867 128 - 1.614 1.590 -0.082
ENSG00000103852 E024 38.3942047 0.0005569998 6.480955e-01 7.596676e-01 15 99175050 99175155 106 - 1.607 1.583 -0.080
ENSG00000103852 E025 47.1350215 0.0064923738 3.368426e-01 4.807068e-01 15 99199919 99200096 178 - 1.712 1.655 -0.195
ENSG00000103852 E026 39.7050431 0.0061557198 3.949509e-02 9.009847e-02 15 99218588 99218697 110 - 1.676 1.537 -0.471
ENSG00000103852 E027 20.0590925 0.0011618300 4.361500e-02 9.767284e-02 15 99218698 99218713 16 - 1.396 1.244 -0.531
ENSG00000103852 E028 0.4772466 0.0219880723 6.446739e-01 7.569272e-01 15 99218714 99218897 184 - 0.129 0.207 0.821
ENSG00000103852 E029 33.6100388 0.0006423812 1.645204e-01 2.810502e-01 15 99218898 99219007 110 - 1.580 1.500 -0.275
ENSG00000103852 E030 21.2947965 0.0009012167 1.573428e-01 2.715656e-01 15 99219008 99219048 41 - 1.402 1.300 -0.353
ENSG00000103852 E031 27.4737634 0.0007427809 3.441066e-02 8.054507e-02 15 99221741 99221795 55 - 1.525 1.390 -0.466
ENSG00000103852 E032 26.6061220 0.0080734008 1.635139e-01 2.797201e-01 15 99221796 99221864 69 - 1.497 1.385 -0.387
ENSG00000103852 E033 0.0000000       15 99228405 99228532 128 -      
ENSG00000103852 E034 15.3607620 0.0014105713 5.479562e-02 1.176452e-01 15 99228533 99228544 12 - 1.302 1.141 -0.567
ENSG00000103852 E035 15.3210211 0.0047221501 6.691009e-02 1.382385e-01 15 99228545 99228552 8 - 1.302 1.141 -0.570
ENSG00000103852 E036 33.4828657 0.0008838066 6.184664e-02 1.297296e-01 15 99228553 99228729 177 - 1.599 1.491 -0.371
ENSG00000103852 E037 10.5529529 0.0054663196 2.384977e-01 3.724023e-01 15 99228730 99228732 3 - 1.129 1.007 -0.442
ENSG00000103852 E038 0.6287620 0.0181063683 8.979992e-01 9.388907e-01 15 99234988 99235078 91 - 0.228 0.207 -0.179
ENSG00000103852 E039 0.2987644 0.0294081100 1.723746e-01   15 99235079 99235080 2 - 0.228 0.000 -13.571
ENSG00000103852 E040 9.3532686 0.0037414252 4.741420e-02 1.045690e-01 15 99241365 99241386 22 - 1.118 0.905 -0.782
ENSG00000103852 E041 19.4571040 0.0013838395 5.657102e-04 2.405335e-03 15 99241387 99241559 173 - 1.442 1.178 -0.921
ENSG00000103852 E042 0.1482932 0.0411597534 5.405461e-01   15 99241560 99241562 3 - 0.000 0.116 11.361
ENSG00000103852 E043 9.4857740 0.0288239728 8.634486e-01 9.159299e-01 15 99245389 99245436 48 - 1.000 1.022 0.080
ENSG00000103852 E044 11.2563269 0.0176822359 8.705636e-02 1.706793e-01 15 99245437 99245510 74 - 1.182 0.983 -0.721
ENSG00000103852 E045 0.7342825 0.0167904541 1.224863e-02 3.413153e-02 15 99248188 99248310 123 - 0.436 0.000 -14.906
ENSG00000103852 E046 20.7094868 0.0010140148 2.908176e-01 4.316070e-01 15 99249171 99249416 246 - 1.377 1.300 -0.268
ENSG00000103852 E047 26.3446791 0.0061910231 2.919007e-03 1.002751e-02 15 99249417 99249621 205 - 1.547 1.320 -0.783
ENSG00000103852 E048 5.2710524 0.0724538298 8.625310e-03 2.534966e-02 15 99249622 99249739 118 - 1.001 0.536 -1.887
ENSG00000103852 E049 3.1965419 0.1671445960 6.299150e-02 1.316936e-01 15 99249740 99249799 60 - 0.816 0.398 -1.890
ENSG00000103852 E050 3.2098808 0.0273999358 3.211109e-03 1.088821e-02 15 99251155 99251223 69 - 0.838 0.347 -2.266