ENSG00000103742

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000352385 ENSG00000103742 HEK293_OSMI2_2hA HEK293_TMG_2hB IGDCC4 protein_coding protein_coding 1.633685 1.771533 2.040488 0.1571721 0.07954091 0.2028478 0.8702421 0.4840848 1.4146669 0.04002329 0.09959141 1.527794 0.5493208 0.2768333 0.6917000 0.4148667 2.862248e-07 2.862248e-07 FALSE TRUE
ENST00000558048 ENSG00000103742 HEK293_OSMI2_2hA HEK293_TMG_2hB IGDCC4 protein_coding processed_transcript 1.633685 1.771533 2.040488 0.1571721 0.07954091 0.2028478 0.6029153 1.1821316 0.3860081 0.09479111 0.12725316 -1.589942 0.3593542 0.6695000 0.1869333 -0.4825667 1.551424e-04 2.862248e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103742 E001 0.2965864 0.122499388 1.410950e-01   15 65381484 65381486 3 - 0.000 0.261 9.917
ENSG00000103742 E002 160.6882836 0.006555743 5.350223e-12 1.163568e-10 15 65381487 65384419 2933 - 2.072 2.336 0.881
ENSG00000103742 E003 0.0000000       15 65384848 65384953 106 -      
ENSG00000103742 E004 11.4307621 0.001667002 1.798305e-01 3.009677e-01 15 65384954 65385115 162 - 1.119 1.043 -0.275
ENSG00000103742 E005 2.2412757 0.090689908 3.170195e-01 4.598537e-01 15 65385459 65385615 157 - 0.401 0.635 1.128
ENSG00000103742 E006 1.6114696 0.159610096 6.640540e-01 7.719533e-01 15 65385616 65385830 215 - 0.355 0.490 0.724
ENSG00000103742 E007 8.3581024 0.002782917 3.471016e-01 4.912801e-01 15 65385831 65386059 229 - 0.983 0.931 -0.192
ENSG00000103742 E008 7.3074633 0.127448289 8.018863e-01 8.737737e-01 15 65386551 65386656 106 - 0.881 0.953 0.269
ENSG00000103742 E009 10.3750920 0.053209360 5.185080e-01 6.527374e-01 15 65388449 65388586 138 - 1.076 1.022 -0.196
ENSG00000103742 E010 13.5023364 0.004969922 9.945161e-01 1.000000e+00 15 65388808 65388978 171 - 1.127 1.183 0.199
ENSG00000103742 E011 10.0951529 0.002860475 1.353714e-01 2.416306e-01 15 65389284 65389411 128 - 1.075 0.972 -0.379
ENSG00000103742 E012 11.7067205 0.001555286 7.141025e-01 8.104124e-01 15 65390155 65390338 184 - 1.084 1.104 0.073
ENSG00000103742 E013 8.8049238 0.002252901 5.489671e-02 1.178177e-01 15 65391880 65391981 102 - 1.046 0.886 -0.597
ENSG00000103742 E014 12.5131306 0.001429032 2.643764e-03 9.202291e-03 15 65392134 65392370 237 - 1.209 0.972 -0.860
ENSG00000103742 E015 10.7239058 0.001757434 9.526805e-03 2.760430e-02 15 65393361 65393531 171 - 1.143 0.931 -0.778
ENSG00000103742 E016 9.5732942 0.041844629 1.229765e-01 2.242044e-01 15 65394411 65394548 138 - 1.083 0.910 -0.641
ENSG00000103742 E017 11.2982800 0.001570713 3.355883e-03 1.130907e-02 15 65395094 65395258 165 - 1.174 0.931 -0.887
ENSG00000103742 E018 9.9438581 0.001912133 1.490715e-04 7.430515e-04 15 65395750 65396163 414 - 1.151 0.780 -1.390
ENSG00000103742 E019 0.3686942 0.029191303 7.890125e-01 8.649325e-01 15 65396164 65396429 266 - 0.098 0.152 0.728
ENSG00000103742 E020 5.2716066 0.027141730 6.145658e-03 1.899340e-02 15 65396834 65396989 156 - 0.921 0.544 -1.553
ENSG00000103742 E021 7.7407615 0.014310213 2.672843e-03 9.291217e-03 15 65400806 65400946 141 - 1.056 0.714 -1.314
ENSG00000103742 E022 7.6500874 0.002332715 9.106402e-02 1.768056e-01 15 65402351 65402487 137 - 0.983 0.836 -0.555
ENSG00000103742 E023 8.7223034 0.006852377 7.671103e-01 8.494219e-01 15 65410178 65410319 142 - 0.971 0.991 0.075
ENSG00000103742 E024 0.7405235 0.015478555 9.584034e-01 9.779179e-01 15 65410366 65410877 512 - 0.245 0.264 0.137
ENSG00000103742 E025 9.6763231 0.001821868 1.116671e-01 2.080087e-01 15 65411020 65411370 351 - 1.066 0.952 -0.419
ENSG00000103742 E026 1.0351233 0.011885495 1.315643e-02 3.627063e-02 15 65422793 65422947 155 - 0.443 0.000 -14.048