ENSG00000103657

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000443617 ENSG00000103657 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC1 protein_coding protein_coding 6.856648 7.295853 3.430856 1.243021 0.1469631 -1.086285 1.1762857 1.03440511 1.1523325 0.02114990 0.17253416 0.15434136 0.21208750 0.15060000 0.33586667 0.18526667 1.861716e-02 6.356233e-16 FALSE TRUE
ENST00000558324 ENSG00000103657 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC1 protein_coding nonsense_mediated_decay 6.856648 7.295853 3.430856 1.243021 0.1469631 -1.086285 0.5920854 0.56597515 0.1203385 0.56597515 0.06028872 -2.14374292 0.08202500 0.11203333 0.03483333 -0.07720000 7.298788e-01 6.356233e-16 TRUE FALSE
ENST00000559996 ENSG00000103657 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC1 protein_coding retained_intron 6.856648 7.295853 3.430856 1.243021 0.1469631 -1.086285 1.2371341 1.99255435 0.1088349 0.44110344 0.10883486 -4.07481140 0.12656250 0.27566667 0.02933333 -0.24633333 2.895780e-02 6.356233e-16 FALSE FALSE
ENST00000561348 ENSG00000103657 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC1 protein_coding retained_intron 6.856648 7.295853 3.430856 1.243021 0.1469631 -1.086285 0.5475558 1.04274978 0.0000000 0.61242285 0.00000000 -6.71801876 0.06087083 0.12046667 0.00000000 -0.12046667 2.344134e-01 6.356233e-16   FALSE
ENST00000561436 ENSG00000103657 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC1 protein_coding retained_intron 6.856648 7.295853 3.430856 1.243021 0.1469631 -1.086285 1.0395514 1.30210305 0.0000000 0.65402295 0.00000000 -7.03573722 0.11565000 0.15563333 0.00000000 -0.15563333 2.240233e-01 6.356233e-16 FALSE FALSE
MSTRG.10995.2 ENSG00000103657 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC1 protein_coding   6.856648 7.295853 3.430856 1.243021 0.1469631 -1.086285 0.3914374 0.08503183 0.0000000 0.03759618 0.00000000 -3.24841087 0.08102083 0.01046667 0.00000000 -0.01046667 2.776551e-01 6.356233e-16 FALSE TRUE
MSTRG.10995.3 ENSG00000103657 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC1 protein_coding   6.856648 7.295853 3.430856 1.243021 0.1469631 -1.086285 0.3251745 0.00000000 0.7127436 0.00000000 0.10068894 6.17541210 0.07356250 0.00000000 0.20753333 0.20753333 6.356233e-16 6.356233e-16 FALSE TRUE
MSTRG.10995.4 ENSG00000103657 HEK293_OSMI2_2hA HEK293_TMG_2hB HERC1 protein_coding   6.856648 7.295853 3.430856 1.243021 0.1469631 -1.086285 1.3002770 1.09912709 1.0407960 0.27212933 0.06364585 -0.07794205 0.20461250 0.15353333 0.30550000 0.15196667 6.068915e-02 6.356233e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103657 E001 29.6824569 0.0335850812 5.579324e-07 4.891643e-06 15 63608618 63608802 185 - 1.090 1.673 2.029
ENSG00000103657 E002 28.8905869 0.0172802630 1.118643e-12 2.721256e-11 15 63608803 63608836 34 - 0.961 1.685 2.542
ENSG00000103657 E003 36.6588398 0.0174345526 2.421970e-12 5.580575e-11 15 63608837 63608876 40 - 1.111 1.777 2.305
ENSG00000103657 E004 53.5945903 0.0090694582 9.478318e-17 4.094024e-15 15 63608877 63609035 159 - 1.317 1.926 2.077
ENSG00000103657 E005 20.4626244 0.0217901129 1.575447e-05 1.000482e-04 15 63609036 63609037 2 - 1.017 1.496 1.690
ENSG00000103657 E006 73.6027264 0.0142647551 3.422463e-08 3.811730e-07 15 63609038 63609266 229 - 1.607 2.021 1.397
ENSG00000103657 E007 91.5324978 0.0118528973 2.013448e-05 1.247747e-04 15 63612251 63612556 306 - 1.791 2.078 0.964
ENSG00000103657 E008 25.9938194 0.0128234041 1.161741e-02 3.262309e-02 15 63615768 63615780 13 - 1.290 1.521 0.800
ENSG00000103657 E009 43.9333837 0.0304698974 2.853735e-04 1.320385e-03 15 63615781 63615920 140 - 1.401 1.788 1.322
ENSG00000103657 E010 56.5246947 0.0094127700 1.275959e-06 1.036075e-05 15 63616430 63616682 253 - 1.538 1.882 1.164
ENSG00000103657 E011 0.7458221 0.0186575548 1.866286e-01 3.095066e-01 15 63616683 63616732 50 - 0.353 0.126 -1.892
ENSG00000103657 E012 24.1945796 0.0008425310 2.058140e-02 5.271242e-02 15 63622815 63622837 23 - 1.290 1.469 0.620
ENSG00000103657 E013 27.6484246 0.0007283410 2.877465e-03 9.903478e-03 15 63622838 63622891 54 - 1.323 1.538 0.740
ENSG00000103657 E014 46.5910210 0.0042626068 1.685902e-03 6.237945e-03 15 63623725 63623890 166 - 1.561 1.763 0.688
ENSG00000103657 E015 39.2564035 0.0027912191 1.081723e-04 5.596709e-04 15 63624158 63624280 123 - 1.456 1.707 0.858
ENSG00000103657 E016 30.6586335 0.0006889759 3.072589e-02 7.337753e-02 15 63624281 63624327 47 - 1.416 1.566 0.515
ENSG00000103657 E017 0.6256415 0.0175551149 3.322638e-01 4.758967e-01 15 63625942 63625984 43 - 0.288 0.126 -1.475
ENSG00000103657 E018 42.9105390 0.0005759126 2.416478e-05 1.471015e-04 15 63625985 63626154 170 - 1.497 1.741 0.832
ENSG00000103657 E019 36.5657445 0.0046101025 9.063330e-04 3.636012e-03 15 63628677 63628815 139 - 1.436 1.671 0.803
ENSG00000103657 E020 30.6801092 0.0015522821 7.205209e-03 2.175897e-02 15 63630466 63630519 54 - 1.389 1.578 0.650
ENSG00000103657 E021 21.4892585 0.0008813612 5.415598e-03 1.705741e-02 15 63630520 63630531 12 - 1.214 1.437 0.781
ENSG00000103657 E022 37.9395027 0.0006080366 1.012717e-04 5.277297e-04 15 63630532 63630635 104 - 1.441 1.681 0.820
ENSG00000103657 E023 0.1482932 0.0426404791 4.687885e-01   15 63630636 63630697 62 - 0.000 0.126 11.289
ENSG00000103657 E024 0.1451727 0.0441375225 5.077527e-01   15 63632291 63632605 315 - 0.118 0.000 -11.347
ENSG00000103657 E025 32.1194485 0.0006669455 1.285109e-03 4.927044e-03 15 63632709 63632811 103 - 1.389 1.605 0.740
ENSG00000103657 E026 31.6553682 0.0006694210 3.235754e-03 1.096079e-02 15 63633848 63633962 115 - 1.395 1.593 0.682
ENSG00000103657 E027 15.7180354 0.0037727272 5.058651e-01 6.415836e-01 15 63633963 63633970 8 - 1.179 1.253 0.263
ENSG00000103657 E028 38.3826516 0.0005747385 2.662618e-03 9.260601e-03 15 63634733 63634888 156 - 1.479 1.666 0.638
ENSG00000103657 E029 0.0000000       15 63634889 63634941 53 -      
ENSG00000103657 E030 42.7224980 0.0021593752 1.365078e-02 3.742981e-02 15 63635961 63636142 182 - 1.542 1.700 0.539
ENSG00000103657 E031 0.8470867 0.0143284528 6.912233e-01 7.927404e-01 15 63636988 63637134 147 - 0.288 0.225 -0.473
ENSG00000103657 E032 38.9719267 0.0006401492 5.287880e-02 1.142758e-01 15 63637505 63637643 139 - 1.522 1.647 0.425
ENSG00000103657 E033 30.5767840 0.0063537758 3.530509e-01 4.972931e-01 15 63638411 63638536 126 - 1.518 1.466 -0.180
ENSG00000103657 E034 20.9265739 0.0178616990 9.501705e-01 9.728287e-01 15 63638711 63638776 66 - 1.317 1.342 0.085
ENSG00000103657 E035 48.3350448 0.0008413239 4.247017e-01 5.676442e-01 15 63640152 63640445 294 - 1.661 1.716 0.188
ENSG00000103657 E036 38.0095516 0.0008682499 1.823220e-01 3.041274e-01 15 63641470 63641643 174 - 1.542 1.633 0.309
ENSG00000103657 E037 25.6336358 0.0008002979 6.496125e-02 1.349716e-01 15 63642957 63643058 102 - 1.342 1.483 0.487
ENSG00000103657 E038 33.9268336 0.0008229583 8.507058e-01 9.074020e-01 15 63643404 63643550 147 - 1.534 1.538 0.012
ENSG00000103657 E039 23.9194332 0.0011668703 7.440521e-01 8.325251e-01 15 63644992 63645097 106 - 1.366 1.404 0.132
ENSG00000103657 E040 31.5477474 0.0007559511 3.602177e-01 5.045352e-01 15 63645483 63645682 200 - 1.530 1.488 -0.144
ENSG00000103657 E041 30.5783895 0.0026313169 7.190744e-01 8.140215e-01 15 63648069 63648199 131 - 1.497 1.489 -0.027
ENSG00000103657 E042 41.0780270 0.0050962993 2.171979e-01 3.470076e-01 15 63649725 63649925 201 - 1.652 1.591 -0.207
ENSG00000103657 E043 26.0306942 0.0010204075 1.724946e-01 2.914374e-01 15 63651253 63651380 128 - 1.470 1.392 -0.268
ENSG00000103657 E044 22.8365709 0.0054327726 3.988993e-01 5.426485e-01 15 63652414 63652541 128 - 1.400 1.349 -0.176
ENSG00000103657 E045 29.7595445 0.0275339915 5.346596e-01 6.666645e-01 15 63654119 63654324 206 - 1.497 1.471 -0.088
ENSG00000103657 E046 25.4442443 0.0154101651 1.438400e-01 2.532345e-01 15 63655742 63655955 214 - 1.470 1.365 -0.363
ENSG00000103657 E047 26.8982740 0.0345320126 8.196777e-02 1.626350e-01 15 63656088 63656358 271 - 1.525 1.357 -0.578
ENSG00000103657 E048 17.5705577 0.0322551575 3.735181e-03 1.239784e-02 15 63658544 63658718 175 - 1.410 1.086 -1.143
ENSG00000103657 E049 23.2423951 0.0008387767 5.763749e-02 1.225711e-01 15 63659736 63659936 201 - 1.441 1.321 -0.417
ENSG00000103657 E050 15.6220349 0.0012039048 2.258464e-01 3.574041e-01 15 63660973 63661025 53 - 1.261 1.172 -0.314
ENSG00000103657 E051 33.1050059 0.0010674333 2.980088e-04 1.371444e-03 15 63661753 63662021 269 - 1.624 1.416 -0.713
ENSG00000103657 E052 6.3945550 0.0025657089 7.059105e-05 3.829686e-04 15 63662984 63663004 21 - 1.066 0.569 -1.978
ENSG00000103657 E053 20.9303425 0.0009843447 2.417714e-06 1.847188e-05 15 63663005 63663204 200 - 1.488 1.141 -1.212
ENSG00000103657 E054 16.8865365 0.0163883319 5.756010e-03 1.797035e-02 15 63664470 63664594 125 - 1.372 1.109 -0.928
ENSG00000103657 E055 25.2420643 0.0199268726 2.019906e-01 3.286909e-01 15 63665919 63666150 232 - 1.465 1.370 -0.330
ENSG00000103657 E056 18.8560400 0.0052214733 5.337560e-02 1.151612e-01 15 63666356 63666472 117 - 1.366 1.219 -0.515
ENSG00000103657 E057 22.5986498 0.0008394850 2.561857e-03 8.947773e-03 15 63669538 63669698 161 - 1.465 1.261 -0.709
ENSG00000103657 E058 21.8056233 0.0008289672 2.083272e-02 5.323804e-02 15 63672496 63672694 199 - 1.431 1.277 -0.537
ENSG00000103657 E059 26.9402749 0.0488087773 3.001791e-02 7.199397e-02 15 63674342 63674740 399 - 1.546 1.327 -0.758
ENSG00000103657 E060 22.3717158 0.0036445088 1.008520e-03 3.987917e-03 15 63674741 63675093 353 - 1.470 1.229 -0.839
ENSG00000103657 E061 1.2489912 0.3759308295 8.079452e-01 8.779556e-01 15 63675094 63675117 24 - 0.352 0.366 0.077
ENSG00000103657 E062 28.6400235 0.0006725410 1.921313e-05 1.196774e-04 15 63677845 63678365 521 - 1.587 1.321 -0.914
ENSG00000103657 E063 13.9610822 0.0013015775 1.244832e-06 1.013212e-05 15 63680077 63680160 84 - 1.348 0.909 -1.585
ENSG00000103657 E064 24.2341742 0.0007782586 6.208597e-06 4.326969e-05 15 63680537 63680776 240 - 1.534 1.228 -1.063
ENSG00000103657 E065 17.9582330 0.0012382828 1.012562e-04 5.276721e-04 15 63686359 63686532 174 - 1.411 1.108 -1.065
ENSG00000103657 E066 6.2015762 0.0296860712 7.368568e-05 3.978424e-04 15 63686533 63686535 3 - 1.078 0.480 -2.443
ENSG00000103657 E067 13.5670957 0.0014489335 4.008540e-07 3.613446e-06 15 63689589 63689699 111 - 1.354 0.890 -1.678
ENSG00000103657 E068 10.6721591 0.0067925339 1.052320e-04 5.461888e-04 15 63690541 63690647 107 - 1.238 0.829 -1.503
ENSG00000103657 E069 11.0429642 0.0018011503 2.798573e-02 6.798503e-02 15 63692411 63692566 156 - 1.179 0.975 -0.738
ENSG00000103657 E070 13.4265526 0.0150772186 8.761464e-02 1.715174e-01 15 63693964 63694157 194 - 1.230 1.063 -0.594
ENSG00000103657 E071 16.0027022 0.0149690820 3.334952e-02 7.848114e-02 15 63694312 63694549 238 - 1.317 1.122 -0.689
ENSG00000103657 E072 9.8411018 0.0017361109 8.673070e-03 2.546672e-02 15 63694774 63694894 121 - 1.151 0.890 -0.960
ENSG00000103657 E073 16.8599183 0.0012901054 5.389544e-03 1.698636e-02 15 63696124 63696339 216 - 1.348 1.131 -0.768
ENSG00000103657 E074 18.0027272 0.0011550071 2.702679e-05 1.625288e-04 15 63698728 63698996 269 - 1.416 1.085 -1.167
ENSG00000103657 E075 8.6545187 0.0045710189 2.819777e-06 2.123880e-05 15 63706780 63706831 52 - 1.188 0.642 -2.091
ENSG00000103657 E076 10.5482944 0.0019609799 4.969594e-07 4.396949e-06 15 63712775 63712895 121 - 1.261 0.732 -1.971
ENSG00000103657 E077 17.9971583 0.0106271811 9.525135e-05 4.997338e-04 15 63713353 63713665 313 - 1.427 1.073 -1.245
ENSG00000103657 E078 17.0634305 0.0546051606 3.048355e-03 1.040863e-02 15 63716302 63716473 172 - 1.417 1.035 -1.352
ENSG00000103657 E079 0.1451727 0.0441375225 5.077527e-01   15 63718429 63718573 145 - 0.118 0.000 -11.347
ENSG00000103657 E080 11.1889372 0.0020620334 4.405718e-06 3.175311e-05 15 63718574 63718694 121 - 1.268 0.807 -1.697
ENSG00000103657 E081 10.6372920 0.0070872508 1.193963e-05 7.793571e-05 15 63718783 63718897 115 - 1.253 0.783 -1.739
ENSG00000103657 E082 11.5733628 0.1466216780 9.538179e-04 3.801046e-03 15 63723182 63723355 174 - 1.328 0.678 -2.432
ENSG00000103657 E083 11.6885846 0.0963467053 5.432809e-04 2.321954e-03 15 63725292 63725513 222 - 1.316 0.737 -2.143
ENSG00000103657 E084 10.5694120 0.0962110276 1.786671e-03 6.556503e-03 15 63727647 63727838 192 - 1.262 0.737 -1.954
ENSG00000103657 E085 6.9804412 0.0023445932 2.659060e-04 1.240766e-03 15 63729236 63729368 133 - 1.078 0.642 -1.698
ENSG00000103657 E086 7.3009635 0.0025607700 2.914458e-05 1.739447e-04 15 63729497 63729649 153 - 1.111 0.607 -1.968
ENSG00000103657 E087 8.3724136 0.0459696842 2.333556e-02 5.844981e-02 15 63732924 63733145 222 - 1.111 0.785 -1.224
ENSG00000103657 E088 0.0000000       15 63734643 63734723 81 -      
ENSG00000103657 E089 5.9181476 0.0028175512 3.254481e-02 7.689030e-02 15 63734724 63734849 126 - 0.961 0.704 -1.006
ENSG00000103657 E090 8.4546810 0.0132832740 2.596012e-04 1.215208e-03 15 63746918 63747083 166 - 1.151 0.704 -1.697
ENSG00000103657 E091 7.8270624 0.0322332660 4.602473e-03 1.482689e-02 15 63747724 63747858 135 - 1.101 0.707 -1.505
ENSG00000103657 E092 8.9231298 0.0019256432 1.961492e-04 9.474651e-04 15 63749367 63749538 172 - 1.160 0.758 -1.509
ENSG00000103657 E093 7.5330193 0.0021359184 1.075846e-05 7.096799e-05 15 63749647 63749791 145 - 1.131 0.607 -2.042
ENSG00000103657 E094 0.0000000       15 63752515 63752957 443 -      
ENSG00000103657 E095 7.0367420 0.0031355323 2.883299e-04 1.332436e-03 15 63752958 63753085 128 - 1.078 0.642 -1.697
ENSG00000103657 E096 8.4845893 0.0121234428 1.163629e-02 3.266690e-02 15 63754505 63754648 144 - 1.100 0.808 -1.095
ENSG00000103657 E097 8.7707805 0.0396844420 4.759379e-02 1.048995e-01 15 63755229 63755325 97 - 1.100 0.835 -0.989
ENSG00000103657 E098 14.0307506 0.0525715846 8.041179e-05 4.298590e-04 15 63756437 63756748 312 - 1.377 0.836 -1.965
ENSG00000103657 E099 6.9708417 0.0229954109 2.113313e-07 2.016328e-06 15 63758175 63758369 195 - 1.151 0.372 -3.278
ENSG00000103657 E100 4.1864881 0.0055076321 2.136191e-06 1.651075e-05 15 63764096 63764191 96 - 0.961 0.224 -3.591
ENSG00000103657 E101 13.5684436 0.0013608290 2.968313e-09 4.030807e-08 15 63774694 63775164 471 - 1.372 0.807 -2.060
ENSG00000103657 E102 2.8129693 0.0993380653 3.664744e-01 5.108078e-01 15 63775165 63775187 23 - 0.649 0.486 -0.745
ENSG00000103657 E103 12.1343183 0.0015810811 4.928510e-05 2.781493e-04 15 63775188 63775563 376 - 1.276 0.890 -1.401
ENSG00000103657 E104 6.8489876 0.0024143247 1.682843e-05 1.061602e-04 15 63775564 63775649 86 - 1.100 0.569 -2.100
ENSG00000103657 E105 0.1451727 0.0441375225 5.077527e-01   15 63779583 63780009 427 - 0.118 0.000 -11.347
ENSG00000103657 E106 0.2924217 0.0272261141 2.119428e-01   15 63780462 63780552 91 - 0.211 0.000 -12.347
ENSG00000103657 E107 1.1929815 0.0120999156 2.162708e-03 7.728788e-03 15 63833822 63833826 5 - 0.545 0.000 -14.348
ENSG00000103657 E108 3.7510838 0.0079887662 1.440965e-05 9.226567e-05 15 63833827 63833948 122 - 0.914 0.224 -3.415