ENSG00000103599

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335894 ENSG00000103599 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCH protein_coding protein_coding 1.82613 0.9096004 3.653437 0.2760313 0.477199 1.994119 0.16518251 0.09530639 0.43163809 0.03064926 0.01374738 2.0682716 0.08087500 0.14943333 0.12260000 -0.026833333 1.000000e+00 2.161155e-05 FALSE TRUE
ENST00000512104 ENSG00000103599 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCH protein_coding protein_coding 1.82613 0.9096004 3.653437 0.2760313 0.477199 1.994119 0.08725342 0.12220785 0.08530628 0.02097406 0.08530628 -0.4721646 0.06606250 0.15970000 0.02420000 -0.135500000 1.583999e-01 2.161155e-05 FALSE TRUE
ENST00000514049 ENSG00000103599 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCH protein_coding nonsense_mediated_decay 1.82613 0.9096004 3.653437 0.2760313 0.477199 1.994119 0.22030820 0.00000000 0.67850531 0.00000000 0.05931743 6.1053959 0.10082917 0.00000000 0.18776667 0.187766667 2.161155e-05 2.161155e-05 FALSE TRUE
ENST00000560497 ENSG00000103599 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCH protein_coding processed_transcript 1.82613 0.9096004 3.653437 0.2760313 0.477199 1.994119 0.05116111 0.05659494 0.11591935 0.02985364 0.06600791 0.9190155 0.05013750 0.05143333 0.03530000 -0.016133333 7.707403e-01 2.161155e-05   FALSE
ENST00000561339 ENSG00000103599 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCH protein_coding nonsense_mediated_decay 1.82613 0.9096004 3.653437 0.2760313 0.477199 1.994119 0.15157933 0.00000000 0.12527919 0.00000000 0.12527919 3.7578681 0.06432500 0.00000000 0.03553333 0.035533333 1.000000e+00 2.161155e-05 FALSE FALSE
ENST00000561357 ENSG00000103599 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCH protein_coding protein_coding 1.82613 0.9096004 3.653437 0.2760313 0.477199 1.994119 0.28802479 0.13249466 0.67458357 0.13249466 0.49989103 2.2643188 0.11440000 0.09293333 0.16423333 0.071300000 8.386958e-01 2.161155e-05 FALSE FALSE
ENST00000629425 ENSG00000103599 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCH protein_coding protein_coding 1.82613 0.9096004 3.653437 0.2760313 0.477199 1.994119 0.24385576 0.10943305 0.49614375 0.03907130 0.04922691 2.0833450 0.13406250 0.11440000 0.13730000 0.022900000 9.230867e-01 2.161155e-05 FALSE TRUE
MSTRG.11098.5 ENSG00000103599 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCH protein_coding   1.82613 0.9096004 3.653437 0.2760313 0.477199 1.994119 0.08274986 0.10300209 0.00000000 0.10300209 0.00000000 -3.4982776 0.09510833 0.12530000 0.00000000 -0.125300000 4.922106e-01 2.161155e-05 FALSE TRUE
MSTRG.11098.6 ENSG00000103599 HEK293_OSMI2_2hA HEK293_TMG_2hB IQCH protein_coding   1.82613 0.9096004 3.653437 0.2760313 0.477199 1.994119 0.27171447 0.10814004 0.53329430 0.05472336 0.04839518 2.2012360 0.14283333 0.15696667 0.14770000 -0.009266667 8.897719e-01 2.161155e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103599 E001 0.7310603 0.053969376 1.000000000 1.00000000 15 67254786 67254799 14 + 0.220 0.214 -0.051
ENSG00000103599 E002 0.7310603 0.053969376 1.000000000 1.00000000 15 67254800 67254800 1 + 0.220 0.214 -0.051
ENSG00000103599 E003 0.7310603 0.053969376 1.000000000 1.00000000 15 67254801 67254803 3 + 0.220 0.214 -0.051
ENSG00000103599 E004 4.4519656 0.017740180 0.650290419 0.76136590 15 67254804 67254847 44 + 0.697 0.623 -0.312
ENSG00000103599 E005 9.8284510 0.029833565 0.554224985 0.68323579 15 67254848 67254947 100 + 0.990 0.905 -0.320
ENSG00000103599 E006 0.8157519 0.018886706 0.332208995 0.47583462 15 67255037 67255321 285 + 0.175 0.358 1.368
ENSG00000103599 E007 8.1121514 0.024313099 0.978154638 0.99046529 15 67261272 67261301 30 + 0.901 0.904 0.013
ENSG00000103599 E008 12.8878500 0.002684409 0.201644889 0.32822693 15 67261302 67261394 93 + 1.111 0.969 -0.518
ENSG00000103599 E009 1.7068484 0.009744790 0.303258156 0.44515569 15 67263122 67263216 95 + 0.424 0.215 -1.369
ENSG00000103599 E010 2.4034784 0.006258526 0.847270567 0.90512903 15 67279395 67279481 87 + 0.498 0.465 -0.164
ENSG00000103599 E011 1.5167500 0.037964246 0.971215532 0.98603918 15 67279482 67279512 31 + 0.366 0.358 -0.050
ENSG00000103599 E012 0.4439371 0.021752076 0.584371123 0.70832761 15 67281592 67282240 649 + 0.175 0.000 -11.214
ENSG00000103599 E013 2.7879786 0.028313339 0.505431470 0.64121424 15 67304339 67304455 117 + 0.499 0.623 0.569
ENSG00000103599 E014 0.7061804 0.020286626 0.195261322 0.32030676 15 67306826 67306828 3 + 0.124 0.358 1.955
ENSG00000103599 E015 1.4080945 0.185619641 0.110460770 0.20621481 15 67306829 67307224 396 + 0.221 0.560 1.985
ENSG00000103599 E016 0.5514428 0.020057824 0.004044289 0.01326578 15 67336975 67337095 121 + 0.000 0.466 14.125
ENSG00000103599 E017 9.2689373 0.001971416 0.905099303 0.94360103 15 67344063 67344191 129 + 0.951 0.969 0.067
ENSG00000103599 E018 10.7459981 0.001722119 0.075294607 0.15199772 15 67357345 67357421 77 + 1.051 0.830 -0.832
ENSG00000103599 E019 6.8322381 0.002406352 0.199327807 0.32539751 15 67359847 67359885 39 + 0.872 0.685 -0.748
ENSG00000103599 E020 0.1817044 0.041508603 0.111958812   15 67359886 67360095 210 + 0.000 0.215 12.607
ENSG00000103599 E021 2.2112666 0.006786224 0.016411174 0.04363759 15 67371428 67371524 97 + 0.542 0.000 -13.176
ENSG00000103599 E022 1.6221568 0.008499976 0.047693508 0.10507247 15 67371525 67371533 9 + 0.450 0.000 -12.807
ENSG00000103599 E023 4.3651846 0.003810865 0.337818690 0.48170782 15 67372111 67372113 3 + 0.711 0.551 -0.692
ENSG00000103599 E024 22.1393762 0.001252872 0.417861654 0.56117446 15 67372114 67372519 406 + 1.312 1.247 -0.229
ENSG00000103599 E025 13.3727028 0.010707310 0.873813595 0.92288897 15 67372520 67372662 143 + 1.094 1.076 -0.064
ENSG00000103599 E026 9.4652020 0.002239395 0.362830714 0.50725049 15 67373367 67373433 67 + 0.982 0.869 -0.426
ENSG00000103599 E027 4.8456509 0.003583670 0.493023628 0.63009341 15 67373434 67374168 735 + 0.682 0.787 0.429
ENSG00000103599 E028 8.3664916 0.002146932 0.416694056 0.56007889 15 67384936 67385019 84 + 0.935 0.830 -0.401
ENSG00000103599 E029 13.4541852 0.001590799 0.739570778 0.82922673 15 67388831 67389006 176 + 1.082 1.120 0.135
ENSG00000103599 E030 3.4492108 0.004945997 0.341170743 0.48507831 15 67395291 67395563 273 + 0.634 0.465 -0.785
ENSG00000103599 E031 8.1022566 0.009900173 0.576199980 0.70168396 15 67400114 67400305 192 + 0.909 0.831 -0.299
ENSG00000103599 E032 9.5636363 0.001809078 0.795751661 0.86959371 15 67416931 67417051 121 + 0.967 0.939 -0.106
ENSG00000103599 E033 12.9968391 0.001516763 0.829052965 0.89262874 15 67421291 67421577 287 + 1.094 1.075 -0.069
ENSG00000103599 E034 8.1740895 0.002438033 0.691609250 0.79304723 15 67465127 67465297 171 + 0.918 0.869 -0.185
ENSG00000103599 E035 6.9518600 0.003012731 0.191967730 0.31623821 15 67475696 67475818 123 + 0.799 0.969 0.653
ENSG00000103599 E036 2.5002862 0.007520470 0.010289248 0.02947807 15 67490003 67490014 12 + 0.366 0.786 1.951
ENSG00000103599 E037 5.0416496 0.003359389 0.072574297 0.14763374 15 67490015 67490064 50 + 0.651 0.905 1.020
ENSG00000103599 E038 10.2143666 0.003868290 0.253538445 0.39006406 15 67494258 67494366 109 + 0.943 1.076 0.488
ENSG00000103599 E039 12.3692044 0.001431492 0.459163339 0.59939519 15 67500633 67500758 126 + 1.038 1.119 0.294
ENSG00000103599 E040 15.3818368 0.039359528 0.091592918 0.17762131 15 67500759 67501804 1046 + 1.089 1.313 0.794
ENSG00000103599 E041 1.1395084 0.011911501 0.620670202 0.73776875 15 67501893 67502260 368 + 0.262 0.358 0.632