ENSG00000103591

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261880 ENSG00000103591 HEK293_OSMI2_2hA HEK293_TMG_2hB AAGAB protein_coding protein_coding 51.21641 39.85541 64.29022 7.620085 2.911611 0.689686 10.321429 9.54227694 12.2743438 2.26905287 0.4574336 0.362904227 0.20754583 0.2367333333 0.191133333 -0.04560000 2.357003e-01 6.281605e-28 FALSE TRUE
ENST00000538028 ENSG00000103591 HEK293_OSMI2_2hA HEK293_TMG_2hB AAGAB protein_coding processed_transcript 51.21641 39.85541 64.29022 7.620085 2.911611 0.689686 3.595891 7.43212379 0.5405608 1.51958924 0.5405608 -3.756740543 0.08408750 0.1855333333 0.008166667 -0.17736667 1.271554e-02 6.281605e-28   FALSE
ENST00000542650 ENSG00000103591 HEK293_OSMI2_2hA HEK293_TMG_2hB AAGAB protein_coding protein_coding 51.21641 39.85541 64.29022 7.620085 2.911611 0.689686 1.149475 0.23106308 3.7681311 0.23106308 0.3622740 3.970190168 0.01871250 0.0066666667 0.058833333 0.05216667 5.852598e-02 6.281605e-28 FALSE TRUE
ENST00000561452 ENSG00000103591 HEK293_OSMI2_2hA HEK293_TMG_2hB AAGAB protein_coding protein_coding 51.21641 39.85541 64.29022 7.620085 2.911611 0.689686 4.229770 2.86302064 6.0126084 0.47649252 0.4828036 1.067820092 0.08328333 0.0748666667 0.093433333 0.01856667 6.127188e-01 6.281605e-28 FALSE TRUE
MSTRG.11096.3 ENSG00000103591 HEK293_OSMI2_2hA HEK293_TMG_2hB AAGAB protein_coding   51.21641 39.85541 64.29022 7.620085 2.911611 0.689686 9.743644 9.61777036 9.5823220 3.05149146 0.6792060 -0.005321651 0.20647917 0.2335333333 0.148933333 -0.08460000 1.902586e-01 6.281605e-28 FALSE TRUE
MSTRG.11096.5 ENSG00000103591 HEK293_OSMI2_2hA HEK293_TMG_2hB AAGAB protein_coding   51.21641 39.85541 64.29022 7.620085 2.911611 0.689686 14.103382 9.78864794 18.4044203 1.13809742 0.1022681 0.910181380 0.27000833 0.2541000000 0.287633333 0.03353333 7.140144e-01 6.281605e-28 FALSE TRUE
MSTRG.11096.6 ENSG00000103591 HEK293_OSMI2_2hA HEK293_TMG_2hB AAGAB protein_coding   51.21641 39.85541 64.29022 7.620085 2.911611 0.689686 7.408829 0.04583565 12.9767636 0.04583565 1.9731712 7.861639668 0.11640417 0.0008333333 0.200400000 0.19956667 6.281605e-28 6.281605e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103591 E001 217.6784856 0.0041097269 6.775834e-03 2.064063e-02 15 67200667 67201672 1006 - 2.280 2.408 0.427
ENSG00000103591 E002 86.3701853 0.0012537340 5.519472e-10 8.586364e-09 15 67201673 67201706 34 - 1.800 2.074 0.923
ENSG00000103591 E003 110.0971076 0.0003432799 2.969189e-13 7.890363e-12 15 67201707 67201715 9 - 1.911 2.180 0.903
ENSG00000103591 E004 1137.9402493 0.0006652294 1.681223e-38 5.281967e-36 15 67201716 67202479 764 - 2.957 3.157 0.664
ENSG00000103591 E005 605.2715621 0.0010011417 1.162743e-03 4.514636e-03 15 67202480 67202739 260 - 2.749 2.829 0.268
ENSG00000103591 E006 446.1766965 0.0008173127 2.332826e-01 3.663153e-01 15 67202740 67202898 159 - 2.660 2.650 -0.033
ENSG00000103591 E007 249.5387516 0.0001849369 1.424495e-02 3.878338e-02 15 67203548 67203597 50 - 2.421 2.386 -0.118
ENSG00000103591 E008 326.9139922 0.0007879089 2.806395e-02 6.814098e-02 15 67204044 67204148 105 - 2.537 2.500 -0.124
ENSG00000103591 E009 360.1421770 0.0001854264 3.256768e-04 1.483601e-03 15 67208562 67208658 97 - 2.586 2.537 -0.164
ENSG00000103591 E010 354.6155020 0.0001523265 2.340154e-06 1.793745e-05 15 67209462 67209544 83 - 2.589 2.519 -0.233
ENSG00000103591 E011 0.3332198 0.0377372933 8.452614e-01   15 67220489 67220540 52 - 0.107 0.140 0.440
ENSG00000103591 E012 0.6028395 0.3952089004 6.341611e-01 7.487126e-01 15 67221039 67221202 164 - 0.266 0.137 -1.185
ENSG00000103591 E013 0.5546650 0.0406348494 4.201132e-01 5.633396e-01 15 67226699 67226950 252 - 0.107 0.246 1.445
ENSG00000103591 E014 273.3193587 0.0001802680 7.020766e-04 2.906543e-03 15 67231814 67231847 34 - 2.471 2.418 -0.176
ENSG00000103591 E015 335.5466887 0.0001496962 7.284445e-06 4.993907e-05 15 67231848 67231897 50 - 2.565 2.498 -0.222
ENSG00000103591 E016 383.4291032 0.0001404813 3.842545e-07 3.475904e-06 15 67235979 67236068 90 - 2.625 2.553 -0.240
ENSG00000103591 E017 313.4434874 0.0002104995 6.373841e-10 9.808343e-09 15 67236408 67236504 97 - 2.552 2.444 -0.358
ENSG00000103591 E018 274.6539050 0.0018196283 1.070848e-05 7.068751e-05 15 67236630 67236717 88 - 2.496 2.379 -0.392
ENSG00000103591 E019 263.2850435 0.0005370387 1.308009e-09 1.897529e-08 15 67236718 67236820 103 - 2.483 2.354 -0.433
ENSG00000103591 E020 0.5911862 0.0193874923 6.967599e-02 1.428268e-01 15 67242737 67242871 135 - 0.326 0.000 -10.095
ENSG00000103591 E021 0.7393776 0.3794283739 6.966248e-01 7.969124e-01 15 67248263 67248321 59 - 0.193 0.319 0.957
ENSG00000103591 E022 5.0632361 0.0748233358 9.455875e-02 1.822256e-01 15 67254224 67254228 5 - 0.904 0.602 -1.227
ENSG00000103591 E023 13.0610133 0.0352483310 2.812370e-01 4.211252e-01 15 67254229 67254413 185 - 1.208 1.085 -0.438
ENSG00000103591 E024 22.0610054 0.0020742843 2.789067e-02 6.779834e-02 15 67254414 67254558 145 - 1.431 1.283 -0.516
ENSG00000103591 E025 166.7042668 0.0038494111 1.620480e-03 6.026600e-03 15 67254559 67254724 166 - 2.280 2.159 -0.404
ENSG00000103591 E026 0.7750806 0.0203894847 2.821736e-01 4.221507e-01 15 67255137 67255195 59 - 0.326 0.140 -1.560