ENSG00000103512

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287667 ENSG00000103512 HEK293_OSMI2_2hA HEK293_TMG_2hB NOMO1 protein_coding protein_coding 101.2492 113.0365 90.49787 6.886985 0.8797102 -0.3208013 79.017256 103.4339856 53.66017 8.8115917 1.975566 -0.9466573 0.76931250 0.914500000 0.5928667 -0.32163333 3.117944e-02 7.100957e-141 FALSE TRUE
ENST00000565655 ENSG00000103512 HEK293_OSMI2_2hA HEK293_TMG_2hB NOMO1 protein_coding protein_coding 101.2492 113.0365 90.49787 6.886985 0.8797102 -0.3208013 1.917328 8.3683423 0.00000 5.3301145 0.000000 -9.7105210 0.01742083 0.074666667 0.0000000 -0.07466667 1.787209e-01 7.100957e-141 TRUE FALSE
MSTRG.12115.4 ENSG00000103512 HEK293_OSMI2_2hA HEK293_TMG_2hB NOMO1 protein_coding   101.2492 113.0365 90.49787 6.886985 0.8797102 -0.3208013 18.295271 0.3621369 33.76941 0.1019526 0.673590 6.5041667 0.19245417 0.003133333 0.3733000 0.37016667 7.100957e-141 7.100957e-141 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103512 E001 0.0000000       16 14833721 14833738 18 +      
ENSG00000103512 E002 0.0000000       16 14833739 14833764 26 +      
ENSG00000103512 E003 0.0000000       16 14833765 14833771 7 +      
ENSG00000103512 E004 0.0000000       16 14833772 14834016 245 +      
ENSG00000103512 E005 0.0000000       16 14838407 14838496 90 +      
ENSG00000103512 E006 0.1472490 0.0432538144 2.790581e-01   16 14841362 14841407 46 + 0.156 0.000 -11.304
ENSG00000103512 E007 0.1472490 0.0432538144 2.790581e-01   16 14844674 14844774 101 + 0.156 0.000 -11.328
ENSG00000103512 E008 0.0000000       16 14846577 14846683 107 +      
ENSG00000103512 E009 0.0000000       16 14848521 14848704 184 +      
ENSG00000103512 E010 0.0000000       16 14848899 14848971 73 +      
ENSG00000103512 E011 0.9566582 0.0490598119 1.458038e-01 2.559545e-01 16 14852430 14852582 153 + 0.437 0.173 -1.828
ENSG00000103512 E012 0.0000000       16 14853054 14853080 27 +      
ENSG00000103512 E013 0.0000000       16 14853256 14853466 211 +      
ENSG00000103512 E014 7.4136848 0.0022952283 7.602244e-02 1.531451e-01 16 14853467 14853604 138 + 1.023 0.821 -0.765
ENSG00000103512 E015 29.1178420 0.0007495812 4.439527e-04 1.943557e-03 16 14853937 14854026 90 + 1.588 1.366 -0.764
ENSG00000103512 E016 97.6594127 0.0003664297 1.667888e-08 1.972880e-07 16 14857217 14857322 106 + 2.093 1.891 -0.675
ENSG00000103512 E017 378.9923422 0.0022067821 2.406547e-18 1.264318e-16 16 14857505 14857655 151 + 2.702 2.454 -0.826
ENSG00000103512 E018 487.2253145 0.0025557278 3.771354e-18 1.933095e-16 16 14863013 14863187 175 + 2.810 2.564 -0.818
ENSG00000103512 E019 379.5202904 0.0033178883 2.140886e-06 1.654434e-05 16 14864585 14864726 142 + 2.649 2.496 -0.509
ENSG00000103512 E020 288.2168650 0.0070617441 2.314071e-02 5.804003e-02 16 14865024 14865155 132 + 2.496 2.396 -0.334
ENSG00000103512 E021 306.6865926 0.0051840434 8.463944e-02 1.668177e-01 16 14866555 14866691 137 + 2.502 2.435 -0.222
ENSG00000103512 E022 106.8908465 0.0003393167 2.784346e-01 4.181186e-01 16 14868548 14868635 88 + 2.027 1.993 -0.114
ENSG00000103512 E023 99.9220739 0.0002836492 1.102983e-01 2.059865e-01 16 14871621 14871684 64 + 1.930 1.996 0.221
ENSG00000103512 E024 137.8846403 0.0025178912 1.099239e-01 2.054330e-01 16 14872234 14872329 96 + 2.152 2.091 -0.203
ENSG00000103512 E025 441.1562342 0.0017251857 7.066717e-03 2.139872e-02 16 14875036 14875254 219 + 2.661 2.593 -0.226
ENSG00000103512 E026 366.1894372 0.0001592205 5.483322e-03 1.724376e-02 16 14875340 14875422 83 + 2.569 2.520 -0.166
ENSG00000103512 E027 560.1253886 0.0002345381 4.675712e-06 3.350859e-05 16 14876359 14876518 160 + 2.767 2.695 -0.238
ENSG00000103512 E028 596.4296097 0.0010854565 4.759034e-03 1.525834e-02 16 14876664 14876790 127 + 2.784 2.727 -0.191
ENSG00000103512 E029 574.6366527 0.0007199681 3.550628e-04 1.599812e-03 16 14878721 14878834 114 + 2.774 2.708 -0.220
ENSG00000103512 E030 328.0722263 0.0017118746 1.007611e-02 2.894790e-02 16 14880015 14880142 128 + 2.533 2.465 -0.229
ENSG00000103512 E031 115.1442913 0.0004391222 4.840186e-01 6.220397e-01 16 14881544 14881685 142 + 2.053 2.034 -0.064
ENSG00000103512 E032 150.9904327 0.0005423873 1.357025e-01 2.420859e-01 16 14882594 14882677 84 + 2.184 2.143 -0.138
ENSG00000103512 E033 473.0756684 0.0002831445 3.042829e-01 4.463002e-01 16 14884372 14884482 111 + 2.633 2.657 0.081
ENSG00000103512 E034 382.6282451 0.0004990279 1.390977e-01 2.468261e-01 16 14886761 14886774 14 + 2.532 2.569 0.124
ENSG00000103512 E035 765.9979077 0.0001198743 1.628643e-03 6.052683e-03 16 14886775 14886862 88 + 2.823 2.872 0.164
ENSG00000103512 E036 10.1856471 0.0017261141 3.414578e-06 2.524810e-05 16 14888054 14889095 1042 + 1.284 0.820 -1.699
ENSG00000103512 E037 651.0799416 0.0013820438 4.393633e-04 1.925856e-03 16 14889096 14889215 120 + 2.726 2.810 0.280
ENSG00000103512 E038 251.5872388 0.0025424811 5.652455e-06 3.975057e-05 16 14894998 14894999 2 + 2.258 2.421 0.545
ENSG00000103512 E039 553.4507261 0.0024112688 3.198231e-08 3.580942e-07 16 14895000 14895090 91 + 2.598 2.760 0.540
ENSG00000103512 E040 359.9897475 0.0041371087 8.363015e-05 4.451917e-04 16 14895514 14895534 21 + 2.421 2.570 0.497
ENSG00000103512 E041 814.4952905 0.0034651772 1.492771e-07 1.465974e-06 16 14895535 14895694 160 + 2.764 2.927 0.543
ENSG00000103512 E042 526.9301406 0.0013150130 1.854628e-24 1.927338e-22 16 14895695 14895972 278 + 2.504 2.759 0.849
ENSG00000103512 E043 285.9590391 0.0021215436 4.575917e-15 1.583946e-13 16 14895973 14896114 142 + 2.234 2.496 0.874
ENSG00000103512 E044 144.7787182 0.0047476328 3.379671e-05 1.984467e-04 16 14896115 14896157 43 + 1.988 2.188 0.670
ENSG00000103512 E045 1.2876999 0.0104447736 9.163440e-01 9.511209e-01 16 14901224 14901455 232 + 0.362 0.346 -0.094