ENSG00000103502

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000219789 ENSG00000103502 HEK293_OSMI2_2hA HEK293_TMG_2hB CDIPT protein_coding protein_coding 122.7044 207.1287 76.66458 9.376338 1.445345 -1.433777 78.901888 117.902013 51.226108 13.0260453 1.1042086 -1.2024779 0.63274583 0.5666333 0.6682000 0.10156667 2.461817e-01 6.749802e-15 FALSE TRUE
ENST00000561555 ENSG00000103502 HEK293_OSMI2_2hA HEK293_TMG_2hB CDIPT protein_coding protein_coding 122.7044 207.1287 76.66458 9.376338 1.445345 -1.433777 6.064907 8.063263 4.918602 0.5101381 0.4649078 -0.7119734 0.05549167 0.0393000 0.0640000 0.02470000 3.999094e-02 6.749802e-15 FALSE TRUE
ENST00000563415 ENSG00000103502 HEK293_OSMI2_2hA HEK293_TMG_2hB CDIPT protein_coding protein_coding 122.7044 207.1287 76.66458 9.376338 1.445345 -1.433777 16.618791 29.294792 13.609127 4.9935984 0.6751234 -1.1055024 0.13911667 0.1399000 0.1774333 0.03753333 3.772341e-01 6.749802e-15 FALSE TRUE
ENST00000569956 ENSG00000103502 HEK293_OSMI2_2hA HEK293_TMG_2hB CDIPT protein_coding protein_coding 122.7044 207.1287 76.66458 9.376338 1.445345 -1.433777 10.670341 34.296335 0.000000 11.2547362 0.0000000 -11.7442593 0.08890833 0.1699667 0.0000000 -0.16996667 6.749802e-15 6.749802e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000103502 E001 12.43450 0.0018052575 5.503132e-03 1.729573e-02 16 29858357 29858357 1 - 0.748 1.107 1.359
ENSG00000103502 E002 22.51830 0.0011000540 7.090021e-02 1.448356e-01 16 29858358 29858361 4 - 1.153 1.320 0.591
ENSG00000103502 E003 38.17581 0.0104541882 8.117818e-01 8.805741e-01 16 29858362 29858367 6 - 1.521 1.507 -0.048
ENSG00000103502 E004 109.19536 0.0051551420 7.453790e-01 8.334235e-01 16 29858368 29858371 4 - 1.938 1.960 0.076
ENSG00000103502 E005 188.93766 0.0032434494 1.368981e-01 2.437632e-01 16 29858372 29858384 13 - 2.137 2.205 0.225
ENSG00000103502 E006 363.92272 0.0050282823 1.356001e-02 3.721483e-02 16 29858385 29858417 33 - 2.385 2.495 0.365
ENSG00000103502 E007 423.61180 0.0049364772 1.048209e-02 2.993594e-02 16 29858418 29858447 30 - 2.451 2.560 0.365
ENSG00000103502 E008 691.76941 0.0030126273 1.071928e-02 3.049794e-02 16 29858448 29858505 58 - 2.683 2.768 0.282
ENSG00000103502 E009 1563.53051 0.0018490763 1.257490e-05 8.166875e-05 16 29858506 29858691 186 - 3.021 3.125 0.346
ENSG00000103502 E010 861.76729 0.0008733504 4.343717e-05 2.483265e-04 16 29858692 29858727 36 - 2.776 2.863 0.292
ENSG00000103502 E011 652.74090 0.0016711329 4.132037e-03 1.351173e-02 16 29858728 29858734 7 - 2.663 2.742 0.263
ENSG00000103502 E012 2922.08817 0.0003964904 1.642850e-04 8.105449e-04 16 29858735 29859149 415 - 3.338 3.385 0.155
ENSG00000103502 E013 934.30900 0.0004488985 8.898138e-01 9.335741e-01 16 29859150 29859174 25 - 2.874 2.880 0.020
ENSG00000103502 E014 1729.07242 0.0005045905 6.699844e-01 7.766036e-01 16 29859175 29859334 160 - 3.148 3.147 -0.004
ENSG00000103502 E015 739.29463 0.0001048821 1.168677e-02 3.278870e-02 16 29859442 29859459 18 - 2.806 2.769 -0.123
ENSG00000103502 E016 1027.20286 0.0003377752 7.027442e-03 2.129647e-02 16 29859460 29859523 64 - 2.950 2.913 -0.124
ENSG00000103502 E017 1097.45187 0.0000733146 2.401303e-08 2.755920e-07 16 29860581 29860662 82 - 3.002 2.934 -0.225
ENSG00000103502 E018 47.60115 0.0009038441 3.440517e-08 3.829812e-07 16 29860663 29861105 443 - 1.811 1.508 -1.031
ENSG00000103502 E019 1381.02128 0.0006492224 1.493905e-03 5.616397e-03 16 29861106 29861259 154 - 3.085 3.039 -0.152
ENSG00000103502 E020 30.86636 0.0053813709 2.489192e-07 2.342497e-06 16 29861260 29861694 435 - 1.677 1.303 -1.287
ENSG00000103502 E021 792.76978 0.0015618167 3.726001e-01 5.170447e-01 16 29862586 29862635 50 - 2.820 2.805 -0.052
ENSG00000103502 E022 876.77438 0.0019815272 5.290648e-02 1.143144e-01 16 29862636 29862720 85 - 2.886 2.843 -0.142
ENSG00000103502 E023 50.01372 0.0071402352 1.806898e-01 3.020564e-01 16 29862721 29862814 94 - 1.682 1.593 -0.303
ENSG00000103502 E024 667.25039 0.0033945593 4.639378e-02 1.027468e-01 16 29862815 29862865 51 - 2.778 2.721 -0.189
ENSG00000103502 E025 359.00567 0.0054721249 3.329938e-01 4.766756e-01 16 29862866 29862869 4 - 2.491 2.458 -0.110
ENSG00000103502 E026 490.58944 0.0088918608 9.310118e-02 1.799751e-01 16 29862870 29862974 105 - 2.657 2.585 -0.239
ENSG00000103502 E027 372.47539 0.0241116856 2.887112e-02 6.974329e-02 16 29862975 29863127 153 - 2.597 2.446 -0.505
ENSG00000103502 E028 212.13633 0.0159134222 1.847167e-02 4.816664e-02 16 29863128 29863414 287 - 2.350 2.203 -0.490